Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones

Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines

(2011) Ashish Anshu et al.   BIOCHEMICAL PHARMACOLOGY

Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib

(2011) Anne C. Mirabella et al.   CHEMISTRY & BIOLOGY

Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma

(2010) Crystal R. Archer et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

(2010) E. Kupperman et al.   CANCER RESEARCH

The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

(2010) Jérôme Clerc et al.   CHEMICAL COMMUNICATIONS

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

(2010) Bogdan I. Florea et al.   CHEMISTRY & BIOLOGY

Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors

(2010) Jérôme Clerc et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

(2010) Michael Screen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

(2010) Paul P. Geurink et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pseudomonas syringaeVirulence Factor Syringolin A Counteracts Stomatal Immunity by Proteasome Inhibition

(2010) Barbara Schellenberg et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

A panel of subunit-selective activity-based proteasome probes

(2010) Martijn Verdoes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Total Synthesis of Syringolin A and B

(2010) Michael C. Pirrung et al.   ORGANIC LETTERS

Total Synthesis of Syringolin A

(2010) Chunhui Dai et al.   ORGANIC LETTERS

Proteasome Activity Imaging and Profiling Characterizes Bacterial Effector Syringolin A

(2010) I. Kolodziejek et al.   PLANT PHYSIOLOGY

Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines

(2009) Jérôme Clerc et al.   CHEMBIOCHEM

Synthesis and Structure-Activity Correlation of a Brunsvicamide-Inspired Cyclopeptide Collection

(2009) Thilo Walther  et al.   CHEMBIOCHEM

Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites

(2009) Matthew Britton et al.   CHEMISTRY & BIOLOGY

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

(2009) O. A. O'Connor et al.   CLINICAL CANCER RESEARCH

Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

(2009) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

(2009) J. Clerc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors

(2009) Francesco Russo et al.   TETRAHEDRON

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

(2008) Michael Groll et al.   NATURE