BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process

(2012) P Gonzalez et al.   CELL DEATH AND DIFFERENTIATION

RIP1 Protein-dependent Assembly of a Cytosolic Cell Death Complex Is Required for Inhibitor of Apoptosis (IAP) Inhibitor-mediated Sensitization to Lexatumumab-induced Apoptosis

(2012) Farhan Basit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF- B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex

(2012) M. Nivon et al.   JOURNAL OF CELL SCIENCE

BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy

(2011) Michelina Festa et al.   AMERICAN JOURNAL OF PATHOLOGY

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

(2011) Martin Gamerdinger et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

(2011) K. Seidel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

BAG1: The Guardian of Anti-Apoptotic Proteins in Acute Myeloid Leukemia

(2011) Sanja Aveic et al.   PLoS One

Bag1 directly routes immature BCR-ABL for proteasomal degradation

(2010) F. Tsukahara et al.   BLOOD

Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy

(2010) William K.K. Wu et al.   DRUG RESISTANCE UPDATES

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

IKK  protein is a target of BAG3 regulatory activity in human tumor growth

(2010) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

(2009) H. Kubota   JOURNAL OF BIOCHEMISTRY

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation

(2009) Jennifer S. Carew et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the Aggresome Pathway in Cancer: Targeting Histone Deacetylase 6-Dependent Protein Degradation

(2008) A. Rodriguez-Gonzalez et al.   CANCER RESEARCH

Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor

(2008) M. Bazzaro et al.   CLINICAL CANCER RESEARCH

Bortezomib-mediated proteasome inhibition as a potential strategy for the treatment of rhabdomyosarcoma

(2008) Francesca Bersani et al.   EUROPEAN JOURNAL OF CANCER

Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1

(2008) Zhen-Xian Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Destabilization of ERBB2 Transcripts by Targeting 3' Untranslated Region Messenger RNA Associated HuR and Histone Deacetylase-6

(2008) G. K. Scott et al.   MOLECULAR CANCER RESEARCH

Transcriptional upregulation of BAG3 upon proteasome inhibition

(2007) Hua-Qin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS