Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 113, Issue 2, Pages 419-425Publisher
WILEY
DOI: 10.1002/jcb.23387
Keywords
OXIDATIVE STRESS; RADIOTHERAPY; CHEMOTHERAPY DRUGS; B-CELL LYMPHOMA; MULTIPLE MYELOMA
Categories
Funding
- [R01CA127958]
- [P30CA086862]
- [R01CA133114]
- [R21CA139182]
- [P50 CA97274]
- [R01CA137198]
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Developing novel combined-modality therapeutic approaches based on understanding of the involvement of redox biology in apoptosis of malignant cells is a promising approach for improving clinical responses in B-cell lymphoma and multiple myeloma. Therapeutic modalities that generate reactive oxygen species (i.e., radiation, photodynamic therapy, and specific chemotherapeutic drugs) have been shown to be selectively cytotoxic to malignant B-cells. In this review, we will discuss agents that induce apoptosis in B-cell tumors by oxidative stress. Subsequently, a novel biochemical rationale (based on fundamental differences in cancer vs. normal cell oxidative metabolism) for combining oxidative stressors with radiotherapy and chemotherapy, that may lead to designing of more effective treatment strategies for B-cell malignancies, will be discussed. Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug-resistance in tumor cells, which is a major determinant of treatment failure in many B-cell malignancies. J. Cell. Biochem. 113: 419425, 2012. (C) 2011 Wiley Periodicals, Inc.
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