Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

Leukotriene B4 Mediates Neutrophil Migration Induced by Heme

(2011) A. P. T. Monteiro et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Going up in flames: necrotic cell injury and inflammatory diseases

(2010) Sreerupa Challa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells

(2010) Sangeetha Sukumari-Ramesh et al.   GLIA

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme Impairs Prostaglandin E2 and TGF-  Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

(2010) B. B. Andrade et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

(2009) T Vanden Berghe et al.   CELL DEATH AND DIFFERENTIATION

Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells

(2009) Leticia A.M. Carneiro et al.   Cell Host & Microbe

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

(2008) S. A. Rushworth et al.   BLOOD

Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes

(2008) Melissa D. Laird et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology