Low-Density Lipoprotein-Cholesterol-Induced Endothelial Dysfunction and Oxidative Stress: The Role of Statins

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome

(2013) Nerea Hermida et al.   CARDIOVASCULAR RESEARCH

Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease

(2013) Meliana Riwanto et al.   CIRCULATION

Lack of protective role of HDL-C in patients with coronary artery disease undergoing elective coronary artery bypass grafting

(2013) E. Angeloni et al.   EUROPEAN HEART JOURNAL

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

(2013) Julie Halkein et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydrogen Peroxide Sensing and Signaling by Protein Kinases in the Cardiovascular System

(2012) Joseph R. Burgoyne et al.   ANTIOXIDANTS & REDOX SIGNALING

Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

(2012) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Vitamin B or L-arginine supplementation in hyperhomocysteinaemia: think twice!: EXPERT'S PERSPECTIVE

(2012) J.-L. Balligand   CARDIOVASCULAR RESEARCH

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells

(2011) Anne R. Diers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Moderate Caveolin-1 Downregulation Prevents NADPH Oxidase–Dependent Endothelial Nitric Oxide Synthase Uncoupling by Angiotensin II in Endothelial Cells

(2011) Irina Lobysheva et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation

(2011) Svetlana N. Reilly et al.   CIRCULATION

Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling

(2011) Charalambos Antoniades et al.   CIRCULATION

Synergistic Effect of Combined HMG-CoA Reductase Inhibitor and Angiotensin-II Receptor Blocker Therapy in Patients With Chronic Heart Failure

(2011) Yasuhiro Maejima et al.   CIRCULATION JOURNAL

Effects of Lipid-Lowering Therapy with Rosuvastatin on Kidney Function and Oxidative Stress in Patients with Diabetic Nephropathy

(2011) Masanori Abe et al.   Journal of Atherosclerosis and Thrombosis

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of Atorvastatin 80 mg/day Versus Simvastatin 20 to 40 mg/day on Frequency of Cardiovascular Events Late (Five Years) After Acute Myocardial Infarction (from the Incremental Decrease in End Points Through Aggressive Lipid Lowering [IDEAL] Trial)

(2010) Terje R. Pedersen et al.   AMERICAN JOURNAL OF CARDIOLOGY

Oxidative Stress and Vascular Function: Implications for Pharmacologic Treatments

(2010) Antje R. Weseler et al.   CURRENT HYPERTENSION REPORTS

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases

(2010) Ming Dong et al.   DRUG DISCOVERY TODAY

Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes

(2010) Arash Haghikia et al.   EUROPEAN HEART JOURNAL

Rosuvastatin added to standard heart failure therapy improves cardiac remodelling in heart failure rats with preserved ejection fraction

(2010) Dulcenombre Gómez-Garre et al.   EUROPEAN JOURNAL OF HEART FAILURE

Efflux and uptake transporters as determinants of statin response

(2010) Alice C Rodrigues   Expert Opinion on Drug Metabolism & Toxicology

Protective effects of statin on cardiac fibrosis and apoptosis in adrenomedullin-knockout mice treated with angiotensin II and high salt loading

(2010) Chii Yamamoto et al.   HYPERTENSION RESEARCH

A Promoter Polymorphism of the Endothelial Nitric Oxide Synthase Gene is Associated With Reduced mRNA and Protein Expression in Failing Human Myocardium

(2010) Amit A. Doshi et al.   JOURNAL OF CARDIAC FAILURE

Statin Therapy for the Prevention of Atrial Fibrillation Trial (SToP AF trial)

(2010) SMITA NEGI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Meta-Analysis of Randomized Controlled Trials of Statins Versus Placebo in Patients With Heart Failure

(2009) Michael J. Lipinski et al.   AMERICAN JOURNAL OF CARDIOLOGY

Comparison of 80 versus 10 mg of Atorvastatin on Occurrence of Cardiovascular Events After the First Event (from the Treating to New Targets [TNT] Trial)

(2009) John C. LaRosa et al.   AMERICAN JOURNAL OF CARDIOLOGY

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

(2009) S. B. Haudek et al.   CARDIOVASCULAR RESEARCH

Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability

(2009) Marika Massaro et al.   CARDIOVASCULAR RESEARCH

Plasma Tetrahydrobiopterin/Dihydrobiopterin Ratio

(2009) Masafumi Takeda et al.   CIRCULATION JOURNAL

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

(2009) Zhen Chen et al.   CIRCULATION RESEARCH

Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins

(2009) Arnold von Eckardstein et al.   CURRENT OPINION IN LIPIDOLOGY

Hypoxic Repression of Endothelial Nitric-oxide Synthase Transcription Is Coupled with Eviction of Promoter Histones

(2009) Jason E. Fish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Editorial Foreword

(2009) Maya Simionescu   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Plasma Concentration of Amino-Terminal Pro-Brain Natriuretic Peptide in Chronic Heart Failure: Prediction of Cardiovascular Events and Interaction With the Effects of Rosuvastatin

(2009) John G.F. Cleland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention

(2009) Pierre Amarenco et al.   LANCET NEUROLOGY

Inhibitors of HMG-CoA Reductase: Current and Future Prospects

(2009) Narender Singh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

(2008) Thomas Münzel et al.   ANNALS OF MEDICINE

Role of Nox4 and Nox2 in Hyperoxia-Induced Reactive Oxygen Species Generation and Migration of Human Lung Endothelial Cells

(2008) Srikanth Pendyala et al.   ANTIOXIDANTS & REDOX SIGNALING

Control of blood pressure variability in caveolin-1-deficient mice: role of nitric oxide identified in vivo through spectral analysis

(2008) Fanny Desjardins et al.   CARDIOVASCULAR RESEARCH

Prevention of Atrial Fibrillation With 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

(2008) Oliver Adam et al.   CIRCULATION

Evidence for Statin Pleiotropy in Humans

(2008) Ping-Yen Liu et al.   CIRCULATION

The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels

(2008) Akiko Imamura et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Activation of p300 Histone Acetyltransferase Activity Is an Early Endothelial Response to Laminar Shear Stress and Is Essential for Stimulation of Endothelial Nitric-oxide Synthase mRNA Transcription

(2008) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pleiotropic Effects of Atorvastatin in Heart Failure: Role in Oxidative Stress, Inflammation, Endothelial Function, and Exercise Capacity

(2008) Pablo F. Castro et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Primary Prevention of Cardiovascular Mortality and Events With Statin Treatments

(2008) Edward J. Mills et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Influence of Pravastatin and Atorvastatin on Markers of Oxidative Stress in Hypercholesterolemic Humans

(2008) Bonnie Ky et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship Between Biomarkers of Oxidized Low-Density Lipoprotein, Statin Therapy, Quantitative Coronary Angiography, and Atheroma Volume

(2008) Seung Hyuk Choi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Observational Studies of Statins in Heart Failure with Preserved Systolic Function

(2008) Hidekatsu Fukuta et al.   Heart Failure Clinics