Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 9, Issue 11, Pages 1272-1283Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955709789878105
Keywords
3-hydroxy-3-methylglutaryl-coenzyme A reductase; alpha-asarone; cardiovascular disease; low density lipoproteins; cholesterol; statins; side effects; structure-based drug design
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Funding
- EDI-IPN
- COFAA-IPN programs
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High levels of cholesterol are a primary risk factor in the development of cardiovascular diseases. In this review, we have summarized the structural, chemical and computational aspects of hypocholesterolemic drugs, both statins and non-statins, that target enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) to block cholesterol biosynthesis.
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