Journal
LEUKEMIA RESEARCH
Volume 33, Issue 10, Pages 1367-1371Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.02.027
Keywords
Murine leukemia virus; Common virus integration; TXNIP; Redox signaling; Acute myeloid leukemia
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Funding
- Dutch Cancer Society Koningin Wilhelmina Fonds
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Thioredoxin-interacting protein (TXNIP) is involved in reactive oxygen species-induced stress responses. In a screen for novel disease genes in murine leukemia virus (MLV)-induced mouse leukemias, we identified Txnip as a frequent target for proviral integration. Ectopic TXNIP expression inhibited the proliferation of myeloid progenitor cells. TXNIP transcript and protein levels were significantly elevated in human AML blasts of certain patients, particularly those harboring translocation t(8:21). Nucleotide sequencing revealed no abnormalities in the TXNIP coding region in AML These findings suggest that deregulated TXNIP expression contributes to MLV-induced murine leukemia as well as human AML. (c) 2009 Elsevier Ltd. All rights reserved.
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