Trypanosoma cruzi Antioxidant Enzymes As Virulence Factors in Chagas Disease

High Throughput Screening against the Peroxidase Cascade of African Trypanosomes Identifies Antiparasitic Compounds That Inactivate Tryparedoxin

(2012) Florian Fueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric Oxide-Derived Oxidants with a Focus on Peroxynitrite: Molecular Targets,Cellular Responses and Therapeutic Implications

(2011) P. Calcerrada et al.   CURRENT PHARMACEUTICAL DESIGN

Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives

(2011) Shane R. Wilkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benznidazole in Trypanosoma cruzi

(2011) Ana M Mejía-Jaramillo et al.   Parasites & Vectors

Mitochondrial involvement in chronic chagasic cardiomyopathy

(2011) Alejandra Báez et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration

(2010) Diego M. Moreno et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

(2010) Mariana Boiani et al.   BIOCHEMICAL PHARMACOLOGY

Differential apoptosis-like cell death in amastigote and trypomastigote forms from Trypanosoma cruzi-infected heart cells in vitro

(2010) E. M. De Souza et al.   CELL AND TISSUE RESEARCH

Trypanosoma cruzi calreticulin: A novel virulence factor that binds complement C1 on the parasite surface and promotes infectivity

(2010) Galia Ramírez et al.   IMMUNOBIOLOGY

Intraphagosomal Peroxynitrite as a Macrophage-derived Cytotoxin against InternalizedTrypanosoma cruzi

(2010) María Noel Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chagas disease

(2010) Anis Rassi et al.   LANCET

Programmed cell death in unicellular parasites: a prerequisite for sustained infection?

(2010) Ger van Zandbergen et al.   TRENDS IN PARASITOLOGY

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Increased Myeloperoxidase Activity and Protein Nitration Are Indicators of Inflammation in Patients with Chagas' Disease

(2009) M. Dhiman et al.   Clinical and Vaccine Immunology

Fighting the oxidative assault: the Trypanosoma cruzi journey to infection

(2009) Lucía Piacenza et al.   CURRENT OPINION IN MICROBIOLOGY

Trypanocidal drugs: mechanisms, resistance and new targets

(2009) Shane R. Wilkinson et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes

(2009) Shivali Gupta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence

(2009) L. Piacenza et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI

(2009) B Zingales et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi

(2009) Igor dos S. Cestari et al.   MOLECULAR IMMUNOLOGY

Systematic structural studies of iron superoxide dismutases from human parasites and a statistical coupling analysis of metal binding specificity

(2009) Jose Fernando Ruggiero Bachega et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Enhanced Nitrosative Stress during Trypanosoma cruzi Infection Causes Nitrotyrosine Modification of Host Proteins

(2008) Monisha Dhiman et al.   AMERICAN JOURNAL OF PATHOLOGY

Peroxiredoxins play a major role in protectingTrypanosoma cruziagainst macrophage- and endogenously-derived peroxynitrite

(2008) Lucía Piacenza et al.   BIOCHEMICAL JOURNAL

Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death inTrypanosoma cruzi

(2008) Florencia Irigoín et al.   BIOCHEMICAL JOURNAL

Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

(2008) Florencia Irigoín et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial generation of reactive oxygen species is enhanced at the Qo site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant

(2008) Jian-Jun Wen et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Purification and biochemical characterization of four iron superoxide dismutases in Trypanosoma cruzi

(2008) Héctor Mateo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice

(2008) J WEN et al.   MICROBES AND INFECTION

Trypanosomiasis vector control in Africa and Latin America

(2008) Chris J Schofield et al.   Parasites & Vectors

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA