Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benznidazole in Trypanosoma cruzi

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

(2011) Belinda S. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved?

(2010) Mariana Boiani et al.   BIOCHEMICAL PHARMACOLOGY

Advances in Chagas disease drug development: 2009–2010

(2010) Frederick S Buckner et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

(2010) Nicola Baker et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi

(2009) Fernanda M.F. Campos et al.   ACTA TROPICA

Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches

(2009) Julio A. Urbina   ACTA TROPICA

Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

(2009) B. S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole

(2008) Silvane M.F. Murta et al.   ACTA TROPICA

Peroxiredoxins play a major role in protectingTrypanosoma cruziagainst macrophage- and endogenously-derived peroxynitrite

(2008) Lucía Piacenza et al.   BIOCHEMICAL JOURNAL

Proteomic Analysis of Trypanosoma cruzi Resistance to Benznidazole

(2008) Hélida M. Andrade et al.   JOURNAL OF PROTEOME RESEARCH

Multiple NADPH–cytochrome P450 reductases from Trypanosoma cruzi

(2008) Patricio Portal et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Trypanosomiasis vector control in Africa and Latin America

(2008) Chris J Schofield et al.   Parasites & Vectors

Geographical clustering of Trypanosoma cruzi I groups from Colombia revealed by low-stringency single specific primer-PCR of the intergenic regions of spliced-leader genes

(2008) Ana María Mejía-Jaramillo et al.   PARASITOLOGY RESEARCH

Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole

(2008) Fernanda B. Nogueira et al.   PARASITOLOGY RESEARCH

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trypanosoma cruzi: Characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations

(2007) Juciane V. Rego et al.   EXPERIMENTAL PARASITOLOGY

Divergence of trypanothione-dependent tryparedoxin cascade into cytosolic and mitochondrial pathways in arsenite-resistant variants of Leishmania amazonensis

(2007) Ju-Yu Hsu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY