Article
Chemistry, Medicinal
Steffen Daum, Vasiliy F. Chekhun, Igor N. Todor, Natalia Yu Lukianova, Yulia V. Shvets, Leopold Sellner, Kerstin Putzker, Joe Lewis, Thorsten Zenz, Inge A. M. de Graaf, Geny M. M. Groothuis, Angela Casini, Oleksii Zozulia, Frank Hampel, Andriy Mokhir
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Giuseppe La Venuta, Sabine Wegehingel, Peter Sehr, Hans-Michael Mueller, Eleni Dimou, Julia P. Steringer, Mareike Grotwinkel, Nikolai Hentze, Matthias P. Mayer, David W. Will, Ulrike Uhrig, Joe D. Lewis, Walter Nickel
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Ales Machara, Vanda Lux, Milan Kozisek, Klara Grantz Saskova, Ondrej Stepanek, Martin Kotora, Kamil Parkan, Marcela Pavova, Baerbel Glass, Peter Sehr, Joe Lewis, Barbara Mueller, Hans-Georg Kraeusslich, Jan Konvalinka
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Medicine, Research & Experimental
Sascha Dietrich, Malgorzata Oles, Junyan Lu, Leopold Sellner, Simon Anders, Britta Velten, Bian Wu, Jennifer Huellein, Michelle da Silva Liberio, Tatjana Walther, Lena Wagner, Sophie Rabe, Sonja Ghidelli-Disse, Marcus Bantscheff, Andrzej K. Oles, Mikolaj Slabicki, Andreas Mock, Christopher C. Oakes, Shihui Wang, Sina Oppermann, Marina Lukas, Vladislav Kim, Martin Sill, Axel Benner, Anna Jauch, Lesley Ann Sutton, Emma Young, Richard Rosenquist, Xiyang Liu, Alexander Jethwa, Kwang Seok Lee, Joe Lewis, Kerstin Putzker, Christoph Lutz, Davide Rossi, Andriy Mokhir, Thomas Oellerich, Katja Zirlik, Marco Herling, Florence Nguyen-Khac, Christoph Plass, Emma Andersson, Satu Mustjoki, Christof von Kalle, Anthony D. Ho, Manfred Hensel, Jan Duerig, Ingo Ringshausen, Marc Zapatka, Wolfgang Huber, Thorsten Zenz
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Geriatrics & Gerontology
Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Medicine, Research & Experimental
Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P. Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W. Hentze, Andreas E. Kulozik
EMBO MOLECULAR MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Sonja Zacherl, Giuseppe La Venuta, Hans-Michael Mueller, Sabine Wegehingel, Eleni Dimou, Peter Sehr, Joe D. Lewis, Holger Erfle, Rainer Pepperkok, Walter Nickel
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Mennatallah Ahmed, Cyril Legrand, Ana Yaguee Relimpio, Carlo A. Beretta, Alina Muschko, Sabine Wegehingel, Hans-Michael Mueller, Peter Sehr, David W. Will, Joe D. Lewis, Walter Nickel
Article
Immunology
Filipe Colaco Mariz, Noemi Bender, Devasena Anantharaman, Partha Basu, Neerja Bhatla, Madhavan Radhakrisna Pillai, Priya R. Prabhu, Rengaswamy Sankaranarayanan, Tiina Eriksson, Michael Pawlita, Kristina Prager, Peter Sehr, Tim Waterboer, Martin Mueller, Matti Lehtinen
Article
Genetics & Heredity
William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Muenster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz
G3-GENES GENOMES GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Andrada-Maria Birladeanu, Malgorzata Rogalska, Myrto Potiri, Vasiliki Papadaki, Margarita Andreadou, Dimitris L. Kontoyiannis, Joe D. Lewis, Zoi Erpapazoglou, Panagiota Kafasla
Summary: The cytosolic scaffold protein IQGAP1 regulates the subnuclear localization of spliceosome components and assists in stress-related splicing mechanisms in gastric cancer cells. It co-regulates cell cycle-related RNA splicing with hnRNPM, promoting gastric cancer cell proliferation. The study reveals a previously unknown link between stress signals and alternative splicing regulation.
Article
Cell Biology
Sebastian M. Dieter, Christine Siegl, Paula L. Codo, Mario Huerta, Anna L. Ostermann-Parucha, Erik Schulz, Martina K. Zowada, Sylvia Martin, Karin Laaber, Ali Nowrouzi, Mona Blatter, Sina Kreth, Frank Westermann, Axel Benner, Ulrike Uhrig, Kerstin Putzker, Joe Lewis, Andrea Haegebarth, Dominik Mumberg, Simon J. Holton, Joerg Weiske, Lena-Marit Toepper, Ulrike Scheib, Gerhard Siemeister, Claudia R. Ball, Bernhard Kuster, Gabriele Stoehr, Hannes Hahne, Sarah Johannes, Martin Lange, Friederike Herbst, Hanno Glimm
Summary: In this study, a novel treatment option for metastatic colorectal cancer (CRC) was identified through drug screening against patient-derived CRC spheroids. The compound NCT02 was found to induce proteasomal degradation of CCNK and CDK12, leading to decreased proliferation of CRC cells. Interestingly, sensitivity to CCNK/CDK12 degradation was associated with TP53 deficiency and consensus molecular subtype 4, highlighting the potential of drug-induced proteolysis for difficult-to-treat cancers.
Article
Oncology
Bjoern-O Gohlke, Fabian Zincke, Andreas Eckert, Dennis Kobelt, Saskia Preissner, Juliane Maria Liebeskind, Nikolas Gunkel, Kerstin Putzker, Joe Lewis, Sally Preissner, Benedikt Kortum, Wolfgang Walther, Cameron Mura, Philip E. Bourne, Ulrike Stein, Robert Preissner
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)