Article
Fisheries
Suying Hou, Wenji Wang, Guoquan Chen, Liqun Xia, Zhiwen Wang, Yishan Lu
Summary: The study investigated the subcellular localization and apoptosis regulation function of NsSOD protein, indicating its potential involvement in apoptosis regulation in fish cells. The findings contribute to further understanding the pathogenic mechanisms of N. seriolae.
JOURNAL OF FISH DISEASES
(2021)
Article
Immunology
Leila dos Santos Moura, Vinicius Santana Nunes, Antoniel A. S. Gomes, Ana Caroline de Castro Nascimento Sousa, Marcos R. M. Fontes, Sergio Schenkman, Nilmar Silvio Moretti
Summary: The research highlights the involvement of lysine acetylation in the oxidative stress response of T. cruzi, especially through the mitochondrial lysine deacetylase TcSir2rp3 regulating the activity of mitochondrial superoxide dismutase A (TcSODA). The study also shows that acetylation of K97 in TcSODA plays a key role in modulating enzyme activity and maintaining redox homeostasis in trypanosomatids. Additionally, the interaction between TcSir2rp3 and TcSODA contributes to the understanding of mechanisms used by T. cruzi to progress during infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaowen Wang, Hong Zhang, Russell Sapio, Jun Yang, Justin Wong, Xin Zhang, Jessie Y. Guo, Sharon Pine, Holly Van Remmen, Hong Li, Eileen White, Chen Liu, Megerditch Kiledjian, Dimitri G. Pestov, X. F. Steven Zheng
Summary: The study reveals a crucial role of nuclear SOD1 in ribosome biogenesis and proliferation in KRAS-driven lung cancer.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Rumiana Bakalova, Ichio Aoki, Zhivko Zhelev, Tatsuya Higashi
Summary: Recent studies have shown that impaired respiration can lead to redox imbalance in NAD(+)/NADH and NADP(+)/NADPH pairs, triggering two metabolic pathways that affect mitochondrial function, senescence, and cell proliferation. The beta-oxidation shuttle disrupts the balance of NAD+/NADH in mitochondria, while the hydride transfer complex (HTC) cycle maintains the balance of NAD(+)/NADH in the cytoplasm and disrupts the balance of NADP(+)/NADPH. Senescence is influenced by high cytoplasmic NADH but low NADPH, while proliferation depends on high levels of cytoplasmic NAD(+) and NADPH, which are regulated by mitochondria. Therefore, controlling the HTC cycle is crucial for determining cell fate - senescence or proliferation.
Article
Chemistry, Physical
Qi-Wen Chen, Meng-Wei Cao, Ji-Yan Qiao, Qian-Ru Li, Xian-Zheng Zhang
Summary: An integrated cascade catalysis for anti-inflammation therapy was developed by decorating catalase-biomimetic ceria nanoparticles onto the Spirulina platensis surface. The resulting biohybrids exhibit excellent catalytic competence for transforming superoxide anion radicals to hydrogen peroxide and subsequently catalyzing its disproportionation. The biohybrids show promising therapeutic effects in ulcerative colitis and Crohn's disease, highlighting their potential for enzyme-based biomedical applications.
NANOSCALE HORIZONS
(2023)
Article
Immunology
Gaurav Agrahari, Shyam Kishor Sah, Chul Hwan Bang, Yeong Ho Kim, Tae-Yoon Kim
Summary: SOD3 attenuates CD4(+)T cell activation by modulating downstream signals and restricting cell differentiation. The study suggests that SOD3 has the potential to be a promising therapeutic for T cell-mediated disorders by inhibiting T cell differentiation and activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Jessica Hickson, Lucas Felipe Almeida Athayde, Thaina Godinho Miranda, Policarpo Ademar Sales Junior, Anderson Coqueiro Dos Santos, Lucia Maria da Cunha Galvao, Antonia Claudia Jacome da Camara, Daniella Castanheira Bartholomeu, Rita de Cassia Moreira de Souza, Silvane Maria Fonseca Murta, Laila Alves Nahum
Summary: This study investigates the genes coding for iron superoxide dismutase (FeSOD) in T. cruzi strains from an evolutionary perspective. The results reveal the molecular biodiversity of T. cruzi FeSODs and identify potential drug targets.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Takahiko Shimizu
Summary: The study showed that p53 regulated ROS-mediated apoptotic cell death and tumorigenesis, but did not affect ROS-mediated tissue degeneration in SOD-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Engineering, Biomedical
Xin Ding, Zidong Wang, Qiying Yu, Nowicki Michal, Szewczyk Roman, Yi Liu, Na Peng
Summary: Mesoporous Fe3O4 nanoparticles (NPs) loaded with pyropheophorbide-a (ppa) and coated with polydopamine (PDA) were synthesized and anchored with tumor-targeting moieties of biotin to obtain Fe/ppa@PDA/B NPs. These NPs exhibited pH/ultrasound responsive release properties and MRI functions. The Fe3O4 NPs served as a source of iron for ferroptosis and enhanced sensitivity by consuming glutathione (GSH) and producing hydroxyl radicals (OH). The quinone groups of PDA layer allowed for effective superoxide dismutase (SOD) action, overcoming hypoxia of sonodynamic therapy (SDT) and promoting the generation of ＊OH by Fe ions under ultrasound trigger, synergistically improving ferroptosis and apoptosis to enhance the efficacy of SDT both in vitro and in vivo. This synergistic apoptosis and ferroptosis strategy provides a new idea for enhancing SDT efficacy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Li-Qiang Wang, Yeyang Ma, Han-Ye Yuan, Kun Zhao, Mu-Ya Zhang, Qiang Wang, Xi Huang, Wen-Chang Xu, Bin Dai, Jie Chen, Dan Li, Delin Zhang, Zhengzhi Wang, Liangyu Zou, Ping Yin, Cong Liu, Yi Liang
Summary: The authors determined the cryo-EM structure of SOD1 fibrils, providing insights into the conversion of SOD1 during the pathogenesis of ALS.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Niccolo Miraglia, Pietro Putignano, Ignazio Castagliuolo, Paola Brun, Stefano Dall'Acqua, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Mara Nichetti, Vittoria Infantino, Simone Perna
Summary: The study showed that supplementation with Saccharomyces boulardii and Superoxide Dismutase led to significant weight loss and reduction in fat mass in obese adults, while maintaining fat free mass. Additionally, a decrease in HOMA index and uric acid levels were observed, providing added benefits in obesity management. Moreover, there was a significant increase in Vitamin D levels in the intervention group, which warrants further investigation.
Article
Biophysics
Caroline G. Sanz, Anca Aldea, Daniela Oprea, Melania Onea, Adrian T. Enache, Madalina M. Barsan
Summary: A novel electrochemical biosensor was developed for the first time to monitor fibroblast cells stress levels in situ under external stimuli. The biosensor exhibited good detection performance in cell culture media, with high sensitivity and correlation. The results suggest the potential application of this biosensor in electrochemical screening of fibroblast cell stress.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Hyehun Choi, Michael R. Miller, Hong-Ngan Nguyen, Victoria E. Surratt, Stephen R. Koch, Ryan J. Stark, Fred S. Lamb
Summary: TNF alpha activates NADPH oxidase 1, which produces extracellular superoxide anion. The secreted protein ecSOD converts superoxide anion to hydrogen peroxide, playing a role in TNF alpha signaling in vascular smooth muscle cells. Knockdown of ecSOD suppresses downstream TNF alpha signals and reduces expression of TNF alpha receptors.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mengqi Zhu, Sainan Min, Xiangdi Mao, Yuan Zhou, Yan Zhang, Wei Li, Li Li, Liling Wu, Xin Cong, Guangyan Yu
Summary: This study revealed that IL-13 plays a critical role in inducing cellular senescence in salivary gland epithelial cells through elevated mitochondrial oxidative stress in the context of IgG4-related sialadenitis. IL-13 activates p-STAT6 and increases mtROS levels, leading to decreased mitochondrial membrane potential and expression/activity of SOD2. IL-13 also enhances the interaction between p-STAT6 and CBP, resulting in reduced transcriptional activity of CREB on SOD2.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Infectious Diseases
Ruben Martin-Escolano, Ruben Cebrian, Mercedes Maqueda, Desiree Romero, Maria Jose Rosales, Manuel Sanchez-Moreno, Clotilde Marin
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2020)
Article
Parasitology
Ruben Martin-Escolano, Javier Martin-Escolano, Rafael Ballesteros-Garrido, Nuria Cirauqui, Belen Abarca, Maria Jose Rosales, Manuel Sanchez-Moreno, Rafael Ballesteros, Clotilde Marin
PARASITOLOGY RESEARCH
(2020)
Article
Chemistry, Inorganic & Nuclear
Amalia Garcia-Garcia, Jose M. Mendez-Arriaga, Ruben Martin-Escolano, Javier Cepeda, Santiago Gomez-Ruiz, Alfonso Salinas-Castillo, Jose M. Seco, Manuel Sanchez-Moreno, Duane Choquesillo-Lazarte, Ana Belen Ruiz-Muelle, Ignacio Fernandez, Clotilde Marin, Antonio Rodriguez-Dieguez
Article
Plant Sciences
Ruben Martin-Escolano, Juan J. Guardia, Javier Martin-Escolano, Nuria Cirauqui, Antonio Fernandez, Maria J. Rosales, Rachid Chahboun, Manuel Sanchez-Moreno, Enrique Alvarez-Manzaneda, Clotilde Marin
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Medicinal
Ruben Martin-Escolano, Mikel Etxebeste-Mitxeltorena, Javier Martin-Escolano, Daniel Plano, Maria J. Rosales, Socorro Espuelas, Esther Moreno, Manuel Sanchez-Moreno, Carmen Sanmartin, Clotilde Marin
Summary: Chagas disease, caused by Trypanosoma cruzi, is a global public health concern with limited treatment options. Selenium and its derivatives have emerged as an interesting strategy for the treatment of various protozoan diseases, including Chagas disease. Further research on selenium compounds shows potential for the development of new antichagasic agents.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Ruben Martin-Escolano, Daniel Molina-Carreno, Daniel Plano, Socorro Espuelas, Maria J. Rosales, Esther Moreno, Carlos Aydillo, Carmen Sanmartin, Manuel Sanchez-Moreno, Clotilde Marin
Summary: Chagas disease is a major public health concern worldwide due to globalization, and the current treatments are limited and outdated, highlighting the urgent need for new therapies to be developed. The in vitro and in vivo activities of forty-eight selenium compounds show potential for a new antichagasic agent, with compound 8 demonstrating promising results that outperform benznidazole.
Article
Parasitology
Ruben Martin-Escolano, Sonia Molero Romero, Jesus G. Diaz, Clotilde Marin, Manuel Sanchez-Moreno, Ma Jose Rosales
Summary: This study evaluated the activity of flavonoid glycosides isolated from medicinal plants against Acanthamoeba castellanii, with compounds 2 and 3 showing potential for the development of novel therapeutic approaches against Acanthamoeba infections.
Article
Chemistry, Medicinal
Alvaro Martin-Montes, Kristina Kolodova, Clotilde Marin, Maria Jose Rosales-Lombardo, Manuel Sanchez-Moreno, Lucia de Andres-Gordo, Carmen Cano, Lucrecia Campayo, Alberto Gomez-Munoz, Ana M. Sanz, Maria J. R. Yunta
Summary: Leishmaniasis and Chagas diseases are important parasitic diseases that cannot be prevented by vaccination. A study was conducted to discover new compounds that could serve as anti-trypanosomal drugs through the synthesis of a synthetic compound family.
Article
Chemistry, Medicinal
Alvaro Martin-Montes, Maria Paz Clares, Ruben Martin-Escolano, Estefania Delgado-Pinar, Clotilde Marin, Begona Verdejo, Alvaro Martinez-Camarena, Daniel Molina-Carreno, Enrique Garcia-Espana, Manuel Sanchez-Moreno
Summary: Leishmaniasis is a neglected disease with no effective human vaccines or treatments, making the development of new therapeutic tools crucial. Research has identified 10 new compounds with promising efficacy against Leishmania species in vitro and in vivo, suggesting they could be potential candidates for leishmaniasis chemotherapy.
ACS INFECTIOUS DISEASES
(2021)
Review
Chemistry, Medicinal
Javier Martin-Escolano, Clotilde Marin, Maria J. Rosales, Anastasios D. Tsaousis, Encarnacion Medina-Carmona, Ruben Martin-Escolano
Summary: This Review provides a comprehensive update on our understanding of Chagas disease, including the current life cycle, new morphological forms, and genetic diversity of the parasite, as well as identifying intervention points in the life cycle where new drugs and treatments could achieve a parasitic cure.
ACS INFECTIOUS DISEASES
(2022)
Article
Parasitology
Ruben Martin-Escolano, Gregorio Perez-Cordon, Vicente J. Aran, Clotilde Marin, Manuel Sanchez-Moreno, Maria Jose Rosales
Summary: This study evaluated the activity of 10 5-nitroindazole derivatives against Acanthamoeba. The results showed the effectiveness of these compounds against both trophozoites and cysts, with derivative 8 showing the highest activity on cysts. These 5-nitroindazole derivatives may be a promising alternative for more efficient treatments against A. castellani infection.
Article
Parasitology
Ruben Martin-Escolano, Maria Jose Rosales, Clotilde Marin
Summary: The T. cruzi Arequipa strain is characterized and evaluated as a model for drug discovery in Chagas disease. The study provides insights into the infection characteristics and benznidazole susceptibility of this strain, suggesting its potential for screening new compounds with anti-parasitic properties.
Article
Pharmacology & Pharmacy
Ruben Martin-Escolano, Daniel Molina-Carreno, Javier Martin-Escolano, M. Paz Clares, Cristina Galiana-Rosello, Jorge Gonzalez-Garcia, Nuria Cirauqui, Jose M. Llinares, Maria Jose Rosales, Enrique Garcia-Espana, Clotilde Marin
Summary: Chagas disease, caused by Trypanosoma cruzi, is a potentially fatal infection that was previously limited to Latin America but has now become widespread globally. This study identified new effective agents against T. cruzi and evaluated their efficacy in vivo. Compound 15 was identified as a potential candidate for the development of new therapies for Chagas disease.
Article
Pharmacology & Pharmacy
Alvaro Martin-Montes, Alvaro Martinez-Camarena, Alberto Lopera, Irene Bonastre-Sabater, M. Paz Clares, Begona Verdejo, Enrique Garcia-Espana, Clotilde Marin
Summary: In order to find effective and side effect-free treatments for all clinical forms of Leishmaniasis, a series of synthetic azamacrocycles were tested against three Leishmania species. Some of the compounds showed leishmanicidal activity and reduced parasite infectivity and dividing ability. Mechanism studies suggested that these compounds altered parasite metabolic pathways and inhibited parasitic Fe-SOD activity.
Article
Parasitology
S. Zamora-Ledesma, N. Hernandez-Camacho, M. Sanchez-Moreno, H. Ruiz-Pina, M. E. Villagran-Herrera, C. Marin-Sanchez, I. G. Carrillo-Angeles, R. W. Jones, B. Camacho-Macias
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2020)
