Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

(2010) Young Bin Hong et al.   PANCREAS

The triterpenoid CDDO limits inflammation in preclinical models of cystic fibrosis lung disease

(2009) David P. Nichols et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2009) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

(2009) L. Gao et al.   CARDIOVASCULAR RESEARCH

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Role of microglial redox balance in modulation of neuroinflammation

(2009) Nadia G Innamorato et al.   CURRENT OPINION IN NEUROLOGY

Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

(2009) Giovanni E Mann et al.   CURRENT OPINION IN PHARMACOLOGY

The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease

(2009) Antonio Cuadrado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice

(2009) N. M. Reddy et al.   JOURNAL OF IMMUNOLOGY

Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice

(2009) Haruo Kanno et al.   JOURNAL OF NEUROTRAUMA

Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice

(2009) Manchang Liu et al.   KIDNEY INTERNATIONAL

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

Converting Redox Signaling to Apoptotic Activities by Stress-Responsive Regulators HSF1 and NRF2 in Fenretinide Treated Cancer Cells

(2009) Kankan Wang et al.   PLoS One

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

(2009) Delinda A. Johnson et al.   TOXICOLOGICAL SCIENCES

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes

(2009) Scott A. Reisman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antiviral Activity of Nrf2 in a Murine Model of Respiratory Syncytial Virus Disease

(2008) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2008) Masaru Suzuki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease

(2008) Willeke MC van Roon-Mom et al.   BMC MOLECULAR BIOLOGY

Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats

(2008) Wei Yan et al.   BRAIN INJURY

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[ a ]pyrene-treated mice: mechanism of its anti-initiating action

(2008) Rachana Garg et al.   CARCINOGENESIS

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Activation of Nrf2 in Defense against Cadmium-Induced Oxidative Stress†

(2008) Xiaoqing He et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Resveratrol protects primary rat hepatocytes against oxidative stress damage:

(2008) Juan Andrés Rubiolo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insulin stimulation of γ-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: Influence of low glucose

(2008) William Langston et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

(2008) C.J. Harvey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin protects retinal cells from light-and oxidant stress-induced cell death

(2008) Md Nawajes A. Mandal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

(2008) Akira Uchiyama et al.   HEPATOLOGY

Simvastatin activates Keap1/Nrf2 signaling in rat liver

(2008) Ioannis G. Habeos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

(2008) Y. Tanaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Adaptive response to GSH depletion and resistance to l-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation

(2008) Hyang-Rim Lee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione

(2008) Saibal K. Biswas et al.   MOLECULAR ASPECTS OF MEDICINE

A new APE1/Ref-1-dependent pathway leading to reduction of NF- B and AP-1, and activation of their DNA-binding activity

(2008) K. Ando et al.   NUCLEIC ACIDS RESEARCH

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

(2008) D Goven et al.   THORAX

Sulforaphane protects against cytokine- and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

(2008) Mi-Young Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Review: Antioxidant therapeutic advances in COPD

(2008) Irfan Rahman   Therapeutic Advances in Respiratory Disease

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury

(2007) Byung-Min Choi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

(2007) Ian M. Copple et al.   TOXICOLOGY