Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

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Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

(2012) Alfiya Distler et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis

(2012) Christian Beyer et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease

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Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

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Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Regulation of self-renewal and differentiation by the intestinal stem cell niche

(2011) Trevor M. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Platelet-derived serotonin links vascular disease and tissue fibrosis

(2011) Clara Dees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

(2010) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis

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