Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents

Self-Liganded Suzuki-Miyaura Coupling for Site-Selective Protein PEGylation

(2013) Anaëlle Dumas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small Molecule–Based Approaches to Adult Stem Cell Therapies

(2013) Luke L. Lairson et al.   Annual Review of Pharmacology and Toxicology

Reprogramming toward Heart Regeneration: Stem Cells and Beyond

(2013) Aitor Aguirre et al.   Cell Stem Cell

An Open-Label Dose Escalation Study to Evaluate the Safety of Administration of Nonviral Stromal Cell-Derived Factor-1 Plasmid to Treat Symptomatic Ischemic Heart Failure

(2013) Marc S. Penn et al.   CIRCULATION RESEARCH

microRNAs in cardiac development and regeneration

(2013) Enzo R. Porrello   CLINICAL SCIENCE

In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration

(2013) W.-Y. Choi et al.   DEVELOPMENT

Therapeutic potential of neuregulin-1 in cardiovascular disease

(2013) Pedro Mendes-Ferreira et al.   DRUG DISCOVERY TODAY

Regenerating new heart with stem cells

(2013) Piero Anversa et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

(2013) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic Exploration of Dual-Acting Modulators from a Combined Medicinal Chemistry and Biology Perspective

(2013) Aurelie Bornot et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

The why and how of phenotypic small-molecule screens

(2013) Ulrike S Eggert   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Proteins and Small Molecules for Cellular Regenerative Medicine

(2013) Eric M. Green et al.   PHYSIOLOGICAL REVIEWS

Regenerative Medicinal Chemistry: The in Situ Control of Stem Cells

(2013) Angela J. Russell   ACS Medicinal Chemistry Letters

Regulated Expression of pH Sensing G Protein-Coupled Receptor-68 Identified through Chemical Biology Defines a New Drug Target for Ischemic Heart Disease

(2012) Jamie L. Russell et al.   ACS Chemical Biology

Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules

(2012) Jamie L. Russell et al.   ACS Chemical Biology

Reawakening Atlas: Chemical Approaches To Repair or Replace Dysfunctional Musculature

(2012) Da-Woon Jung et al.   ACS Chemical Biology

Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

(2012) Se-Woong Oh et al.   ARCHIVES OF PHARMACAL RESEARCH

Chemical approaches to studying stem cell biology

(2012) Wenlin Li et al.   CELL RESEARCH

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

(2012) Erik Willems et al.   Cell Stem Cell

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

(2012) Glen F. Deleavey et al.   CHEMISTRY & BIOLOGY

The Bispecific SDF1-GPVI Fusion Protein Preserves Myocardial Function After Transient Ischemia in Mice

(2012) Melanie Ziegler et al.   CIRCULATION

MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes

(2012) Tilanthi M. Jayawardena et al.   CIRCULATION RESEARCH

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines

(2012) Stefan Berg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling

(2012) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Towards regenerative therapy for cardiac disease

(2012) Leon M Ptaszek et al.   LANCET

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

(2012) Eva van Rooij et al.   NATURE REVIEWS DRUG DISCOVERY

Wnt/ -catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

(2012) K. C. Davidson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

(2012) Itsunari Minami et al.   Cell Reports

Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells

(2011) Rodolfo Gonzalez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impedance-Based Detection of Beating Rhythm and Proarrhythmic Effects of Compounds on Stem Cell-Derived Cardiomyocytes

(2011) Malin K.B. Jonsson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

(2011) Thazha P. Prakash   CHEMISTRY & BIODIVERSITY

Discovering Small Molecules that Promote Cardiomyocyte Generation by Modulating Wnt Signaling

(2011) Terri T. Ni et al.   CHEMISTRY & BIOLOGY

Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell–Derived Mesoderm

(2011) Erik Willems et al.   CIRCULATION RESEARCH

miR-15 Family Regulates Postnatal Mitotic Arrest of Cardiomyocytes

(2011) Enzo R. Porrello et al.   CIRCULATION RESEARCH

Developmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells

(2011) Anthony C. Sturzu et al.   CIRCULATION RESEARCH

The Art of MicroRNA Research

(2011) Eva van Rooij   CIRCULATION RESEARCH

Inhibition of miR-15 Protects Against Cardiac Ischemic Injury

(2011) Thomas G. Hullinger et al.   CIRCULATION RESEARCH

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle

(2011) Alleyn T. Plowright et al.   DRUG DISCOVERY TODAY

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges

(2011) Jörn Tongers et al.   EUROPEAN HEART JOURNAL

Wnt Inhibition Correlates with Human Embryonic Stem Cell Cardiomyogenesis: A Structure–Activity Relationship Study Based on Inhibitors for the Wnt Response

(2011) Marion Lanier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart

(2011) Georgina M. Ellison et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

A Chemical Biology Approach to Myocardial Regeneration

(2011) Erik Willems et al.   Journal of Cardiovascular Translational Research

Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt/β-Catenin Signaling

(2010) Hanmin Wang et al.   ACS Chemical Biology

Chemical Control of Stem Cell Fate and Developmental Potential

(2010) Costas A. Lyssiotis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Cardiomyogenesis in the Adult Human Heart

(2010) Jan Kajstura et al.   CIRCULATION RESEARCH

The translatability of animal models for clinical development: biomarkers and disease models

(2010) Alexandra Wendler et al.   CURRENT OPINION IN PHARMACOLOGY

Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

(2010) Andrew Jabbour et al.   EUROPEAN JOURNAL OF HEART FAILURE

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues

(2010) Punit P. Seth et al.   JOURNAL OF ORGANIC CHEMISTRY

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Phase II, Randomized, Double-Blind, Multicenter, Based on Standard Therapy, Placebo-Controlled Study of the Efficacy and Safety of Recombinant Human Neuregulin-1 in Patients With Chronic Heart Failure

(2010) Runlin Gao et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

(2010) R. M. Kanashiro-Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38 Mitogen-Activated Protein Kinase Controls a Switch Between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating Myocyte Enhancer Factor 2C-Dependent Bone Morphogenetic Protein 2 Transcription

(2010) Jinzhan Wu et al.   STEM CELLS AND DEVELOPMENT

Site-specific PEGylation of proteins by a Staudinger-phosphite reaction

(2010) Remigiusz Serwa et al.   Chemical Science

Protein Therapeutics for Cardiac Regeneration after Myocardial Infarction

(2010) Vincent F. M. Segers et al.   Journal of Cardiovascular Translational Research

Can we prevent immunogenicity of human protein drugs?

(2009) D W Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Structure–activity relationship studies of small-molecule inhibitors of Wnt response

(2009) Jianming Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cardioprotective growth factors

(2009) D. J. Hausenloy et al.   CARDIOVASCULAR RESEARCH

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction

(2009) Marc-Michael Zaruba et al.   Cell Stem Cell

Heart Disease and Stroke Statistics—2009 Update

(2009) et al.   CIRCULATION

Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction

(2009) M. Elena Padin-Iruegas et al.   CIRCULATION

Emerging PEGylated drugs

(2009) Jung Seok Kang et al.   EXPERT OPINION ON EMERGING DRUGS

Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function

(2009) Robert C. Scott et al.   FASEB JOURNAL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

The Importance of Wnt Signaling in Cardiovascular Development

(2009) Ying Tian et al.   PEDIATRIC CARDIOLOGY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine

(2009) Paul S. Knoepfler   STEM CELLS

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue

(2008) Robert C Scott et al.   Expert Opinion on Drug Delivery

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

(2008) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Effects of glycosylation on the stability of protein pharmaceuticals

(2008) Ricardo J. Solá et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Cardiogenic small molecules that enhance myocardial repair by stem cells

(2008) H. Sadek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK

(2007) Ralph Graichen et al.   DIFFERENTIATION

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY