DNA Repair—A Double-Edged Sword in the Genomic Stability of Cancer Cells—The Case of Chronic Myeloid Leukemia

BCR/ABL oncogene-induced PI3K signaling pathway leads to chronic myeloid leukemia pathogenesis by impairing immuno-modulatory function of hemangioblasts

(2015) Q Li et al.   CANCER GENE THERAPY

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

(2015) Mrinal Srivastava et al.   CHEMISTRY & BIOLOGY

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias

(2015) Nidal Muvarak et al.   MOLECULAR CANCER RESEARCH

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Human Structural Variation: Mechanisms of Chromosome Rearrangements

(2015) Brooke Weckselblatt et al.   TRENDS IN GENETICS

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

The Smc5-Smc6 heterodimer associates with DNA through several independent binding domains

(2015) Marc-André Roy et al.   Scientific Reports

The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer

(2015) Erhong Meng et al.   Cancers

Development of cancer-initiating cells and immortalized cells with genomic instability

(2015) Ken-ichi Yoshioka   World Journal of Stem Cells

Structural Maintenance of Chromosomes 4 is a Predictor of Survival and a Novel Therapeutic Target in Colorectal Cancer

(2015) Xiao-Dong Feng et al.   Asian Pacific Journal of Cancer Prevention

DNA Double-strand Break Repair in a Cellular Context

(2014) A. Shibata et al.   CLINICAL ONCOLOGY

Nonhomologous end joining: A good solution for bad ends

(2014) Crystal A. Waters et al.   DNA REPAIR

Current and future management of Ph/BCR-ABL positive ALL

(2014) Elena Maino et al.   Expert Review of Anticancer Therapy

Molecular Defects in Mastocytosis

(2014) Siham Bibi et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

(2014) Zhiqiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells

(2014) M Nieborowska-Skorska et al.   LEUKEMIA

Closing the cohesin ring: Structure and function of its Smc3-kleisin interface

(2014) T. G. Gligoris et al.   SCIENCE

Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel disease

(2014) Ferenc Sipos   WORLD JOURNAL OF GASTROENTEROLOGY

ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia

(2013) Masatoshi Takagi et al.   DNA REPAIR

The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome

(2013) Juana V. Martín-López et al.   Familial Cancer

The Role of Mitochondrial DNA Damage and Repair in the Resistance of BCR/ABL-Expressing Cells to Tyrosine Kinase Inhibitors

(2013) Sylwester Glowacki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross talk between Wnt/β-catenin andIrf8in leukemia progression and drug resistance

(2013) Marina Scheller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-oxidant vitamin E prevents accumulation of imatinib-resistant BCR-ABL1 kinase mutations in CML-CP xenografts in NSG mice

(2013) M Nieborowska-Skorska et al.   LEUKEMIA

Adherence to imatinib therapy in gastrointestinal stromal tumors and chronic myeloid leukemia

(2013) Jasem Al-Barrak et al.   SUPPORTIVE CARE IN CANCER

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

(2012) T. Popova et al.   CANCER RESEARCH

BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability

(2012) A Slupianek et al.   LEUKEMIA

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation

(2012) Krzysztof Flis et al.   LEUKEMIA & LYMPHOMA

The Smc complexes in DNA damage response

(2012) Nan Wu et al.   Cell and Bioscience

Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair

(2011) H. H. Baydoun et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance

(2011) Hilmar Quentmeier et al.   Journal of Hematology & Oncology

Genomic instability and cancer: an introduction

(2011) Z. Shen   Journal of Molecular Cell Biology

Functional phosphoproteomic analysis reveals cold-shock domain protein A to be a Bcr-Abl effector-regulating proliferation and transformation in chronic myeloid leukemia

(2011) D Sears et al.   Cell Death & Disease

Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells

(2010) Christina Bauerschmidt et al.   EXPERIMENTAL CELL RESEARCH

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

(2010) Sebastian M.B. Nijman   FEBS LETTERS

Genome-wide Reinforcement of Cohesin Binding at Pre-existing Cohesin Sites in Response to Ionizing Radiation in Human Cells

(2010) Beom-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia

(2010) D Bixby et al.   LEUKEMIA

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Epidemiologic study on survival of chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia patients with BCR-ABL T315I mutation

(2009) F. E. Nicolini et al.   BLOOD

RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?

(2009) Eri Kinoshita et al.   CHROMOSOME RESEARCH

Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair

(2008) Annahita Sallmyr et al.   CANCER LETTERS

FoxO tumor suppressors and BCR–ABL-induced leukemia: A matter of evasion of apoptosis

(2007) Zainab Jagani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

DNA damage and repair in children with Down's syndrome

(2007) Zbigniew Morawiec et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS