The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome

ATP Alters the Diffusion Mechanics of MutS on Mismatched DNA

(2012) Won-Ki Cho et al.   STRUCTURE

Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates

(2011) Hans Hombauer et al.   CELL

Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies

(2011) Karin Hardt et al.   Familial Cancer

Human MSH2 (hMSH2) Protein Controls ATP Processing by hMSH2-hMSH6

(2011) Christopher D. Heinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

MutS switches between two fundamentally distinct clamps during mismatch repair

(2011) Cherlhyun Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-Molecule FRET TACKLE Reveals Highly Dynamic Mismatched DNA−MutS Complexes

(2010) Lauryn E. Sass et al.   BIOCHEMISTRY

The endonuclease domain of MutL interacts with the β sliding clamp

(2010) Monica C. Pillon et al.   DNA REPAIR

Structure of the Endonuclease Domain of MutL: Unlicensed to Cut

(2010) Monica C. Pillon et al.   MOLECULAR CELL

Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice

(2010) Jason Gorman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-Molecule Analysis Reveals the Kinetics and Physiological Relevance of MutL-ssDNA Binding

(2010) Jonghyun Park et al.   PLoS One

PCNA function in the activation and strand direction of MutL  endonuclease in mismatch repair

(2010) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay

(2009) Hiromu Naruse et al.   Familial Cancer

Evidence That Nucleosomes Inhibit Mismatch Repair in Eukaryotic Cells

(2009) Feng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the β Clamp in Methyl-directed Mismatch Repairin Vitro

(2009) Anna Pluciennik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome Remodeling by hMSH2-hMSH6

(2009) Sarah Javaid et al.   MOLECULAR CELL

Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation

(2009) A. Mazurek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in Single-Molecule Fluorescence Methods for Molecular Biology

(2008) Chirlmin Joo et al.   Annual Review of Biochemistry

MSH2missense mutations and HNPCC syndrome: pathogenicity assessment in a human expression system

(2008) Laura Belvederesi et al.   HUMAN MUTATION

Mechanisms of pathogenicity in humanMSH2missense mutants

(2008) Saara Ollila et al.   HUMAN MUTATION

A large fraction of unclassified variants of the mismatch repair genesMLH1andMSH2is associated with splicing defects

(2008) Isabelle Tournier et al.   HUMAN MUTATION

The PMS2 Subunit of Human MutLα Contains a Metal Ion Binding Domain of the Iron-Dependent Repressor Protein Family

(2008) Jan Kosinski et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Visualization of Asymmetric Adenine Nucleotide-Induced Conformational Changes in MutLα

(2008) Elizabeth J. Sacho et al.   MOLECULAR CELL

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS