Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate Negative Peripheral Action

(2014) Wei Wei et al.   Cell Metabolism

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects

(2013) Shannon M. Harlan et al.   Cell Metabolism

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

(2012) Jyrki P. Kukkonen   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity

(2012) Patricia M. Kane   CURRENT PROTEIN & PEPTIDE SCIENCE

Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly

(2012) Yanqing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

(2012) Eric M. Wauson et al.   MOLECULAR CELL

Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy

(2012) Naoki Ito et al.   NATURE MEDICINE

Neuroprotective Effect of Orexin-A Is Mediated by an Increase of Hypoxia-inducible Factor-1 Activity in Rat

(2011) Li-bang Yuan et al.   ANESTHESIOLOGY

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

The orexin system: roles in sleep/wake regulation

(2010) Takeshi Sakurai et al.   Annals of the New York Academy of Sciences

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orexin A-induced extracellular calcium influx in prefrontal cortex neurons involves L-type calcium channels

(2010) J. X. Xia et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Involvement of TRPC3 channels in calcium oscillations mediated by OX1 orexin receptors

(2009) Hanna M. Peltonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

(2009) Hiromasa Funato et al.   Cell Metabolism

The brain hypocretins and their receptors: mediators of allostatic arousal

(2009) Matthew E Carter et al.   CURRENT OPINION IN PHARMACOLOGY

hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

(2008) Ying Yan et al.   BIOCHEMICAL JOURNAL

Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

(2008) Sylvain Lebreton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling inDrosophila

(2008) Gábor Juhász et al.   JOURNAL OF CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE