Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells

Adalimumab in the Treatment of Immune-Mediated Diseases

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Anti-TNF Agents as Therapeutic Choice in Immune-Mediated Inflammatory Diseases: Focus on Adalimumab

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Effectiveness and cost-effectiveness of interferon beta and glatiramer acetate in the UK Multiple Sclerosis Risk Sharing Scheme at 6 years: a clinical cohort study with natural history comparator

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IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity

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Pivotal role of choline metabolites in remyelination

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IgG1 anti-epidermal growth factor receptor antibodies induce CD8-dependent antitumor activity

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Generation of improved humanized mouse models for human infectious diseases

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Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cells

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Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis

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Humanized NOD-SCID IL2rg –/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

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Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

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Subclinical CNS Inflammation as Response to a Myelin Antigen in Humanized Mice

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T-cell resistance to regulation in RRMS linked to IL-6 pathway

(2013) Katy Malpass   Nature Reviews Neurology

Kinetics of IL-6 Production Defines T Effector Cell Responsiveness to Regulatory T Cells in Multiple Sclerosis

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In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling

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Tocilizumab: A Review of Its Use in the Treatment of Juvenile Idiopathic Arthritis

(2013) James E. Frampton   PEDIATRIC DRUGS

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

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The problems and promises of research into human immunology and autoimmune disease

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Autoimmunity's next top models

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Disease Amelioration With Tocilizumab in a Treatment-Resistant Patient With Neuromyelitis Optica

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Boosting regulatory T cell function by CD4 stimulation enters the clinic

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Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

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IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer

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CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

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Effectiveness and safety of the interleukin 6-receptor antagonist tocilizumab after 4 and 24 weeks in patients with active rheumatoid arthritis: the first phase IIIb real-life study (TAMARA)

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Mouse models for multiple sclerosis: Historical facts and future implications

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Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells

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Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

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Interferon Beta–Induced Restoration of Regulatory T-Cell Function in Multiple Sclerosis Is Prompted by an Increase in Newly Generated Naive Regulatory T Cells

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APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes

(2008) Yulan Jin et al.   CLINICAL IMMUNOLOGY

Multiple Sclerosis and Regulatory T Cells

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The role of regulatory T cells in multiple sclerosis

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