Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Identification in Silico and Experimental Validation of Novel Phosphodiesterase 7 Inhibitors with Efficacy in Experimental Autoimmune Encephalomyelitis Mice

(2012) Miriam Redondo et al.   ACS Chemical Neuroscience

Vinpocetine Inhibits Oligodendroglial Precursor Cell Differentiation

(2012) Klintsy Julieta Torres et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

(2012) Louise Cathrine Braun Olsen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Rolipram promotes remyelination possibly via MEK-ERK signal pathway in cuprizone-induced demyelination mouse

(2012) Xiaojia Sun et al.   EXPERIMENTAL NEUROLOGY

Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination

(2012) Frédéric Bernard et al.   GLIA

Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microgliain vitroand following CNS injury

(2012) Mousumi Ghosh et al.   GLIA

Thymosin beta 4 mediates oligodendrocyte differentiation by upregulating p38 MAPK

(2012) Manoranjan Santra et al.   GLIA

Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds

(2012) Miriam Redondo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase isoform-specific expression induced by traumatic brain injury

(2012) Anthony A. Oliva et al.   JOURNAL OF NEUROCHEMISTRY

The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

(2012) Cristina Susín et al.   JOURNAL OF NEUROCHEMISTRY

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

(2012) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Minocycline protects oligodendroglial precursor cells against injury caused by oxygen-glucose deprivation

(2012) Thomas Schmitz et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

(2012) Emily M. Johansson et al.   NEUROSCIENCE LETTERS

Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination

(2011) De-Hyung Lee et al.   ACTA NEUROPATHOLOGICA

Olesoxime accelerates myelination and promotes repair in models of demyelination

(2011) Karine Magalon et al.   ANNALS OF NEUROLOGY

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

(2011) R. A. Linker et al.   BRAIN

Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system

(2011) Gabrièle Piaton et al.   BRAIN

Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor

(2011) Oscar Gonzalez-Perez et al.   BRAIN RESEARCH REVIEWS

Silencing or knocking out the Na+/Ca2+ exchanger-3 (NCX3) impairs oligodendrocyte differentiation

(2011) F Boscia et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

(2011) Miriam Redondo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo

(2011) Kasum Azim et al.   GLIA

Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system

(2011) Céline Caillava et al.   JOURNAL OF CELL BIOLOGY

Fibroblast Growth Factor Signaling Is Required for the Generation of Oligodendrocyte Progenitors from the Embryonic Forebrain

(2011) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Targeting Oligodendrocyte Protection and Remyelination in Multiple Sclerosis

(2011) Jingya Zhang et al.   MOUNT SINAI JOURNAL OF MEDICINE

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

(2011) Irene Paterniti et al.   PLoS One

Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease

(2011) Jose A. Morales-Garcia et al.   PLoS One

Type 4 Phosphodiesterase Plays Different Integrating Roles in Different Cellular Domains in Pyramidal Cortical Neurons

(2010) L. R. V. Castro et al.   JOURNAL OF NEUROSCIENCE

Stem cell transplantation in multiple sclerosis: current status and future prospects

(2010) Gianvito Martino et al.   Nature Reviews Neurology

Ibudilast in relapsing-remitting multiple sclerosis: A neuroprotectant?

(2010) F. Barkhof et al.   NEUROLOGY

CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination

(2010) J. R. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions

(2009) Andrew P. D. Henderson et al.   ANNALS OF NEUROLOGY

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

(2009) Sha Mi et al.   ANNALS OF NEUROLOGY

Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation

(2009) Junqing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

(2009) Tania Castaño et al.   ChemMedChem

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

(2009) K. Arai et al.   JOURNAL OF NEUROSCIENCE

Fyn kinase is involved in oligodendroglial cell differentiation induced by apotransferrin

(2009) M.J. Perez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury

(2009) E. Beaumont et al.   NEUROSCIENCE

Pharmacogenomics of multiple sclerosis: in search for a personalized therapy

(2008) Iván Martinez-Forero et al.   EXPERT OPINION ON PHARMACOTHERAPY

Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis

(2008) Ajaib S. Paintlia et al.   GLIA

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

(2008) Akiko Nishiyama et al.   NATURE REVIEWS NEUROSCIENCE

Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury

(2008) Christopher M. Whitaker et al.   NEUROSCIENCE LETTERS

FTY720 modulates human oligodendrocyte progenitor process extension and survival

(2007) Veronique E. Miron et al.   ANNALS OF NEUROLOGY

CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

(2007) Ana Castro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY