The problems and promises of research into human immunology and autoimmune disease

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

(2011) Lotte A. van de Stadt et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association studies in multiple sclerosis: lessons and future prospects

(2011) A. Kemppinen et al.   Briefings in Functional Genomics

Clinical Pharmacogenetics of Methotrexate

(2011) Pasqualina Castaldo et al.   CURRENT DRUG METABOLISM

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers

(2011) Wendy W. Unger et al.   JOURNAL OF AUTOIMMUNITY

New hope for immune intervention therapy in type 1 diabetes

(2011) Bart O Roep   LANCET

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

(2010) D. van der Woude et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence for a two-stage disability progression in multiple sclerosis

(2010) E. Leray et al.   BRAIN

Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis

(2010) A. Kaas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

In Vivo Imaging of Partially Reversible Th17 Cell-Induced Neuronal Dysfunction in the Course of Encephalomyelitis

(2010) Volker Siffrin et al.   IMMUNITY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

(2010) Matthias Heinig et al.   NATURE

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Hints of hidden heritability in GWAS

(2010) Greg Gibson   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Multiple sclerosis genetics—is the glass half full, or half empty?

(2010) Jorge R. Oksenberg et al.   Nature Reviews Neurology

Multiple sclerosis – candidate mechanisms underlying CNS atrophy

(2010) Volker Siffrin et al.   TRENDS IN NEUROSCIENCES

Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis

(2009) Johannes Vogt et al.   ANNALS OF NEUROLOGY

What role for genetics in the prediction of multiple sclerosis?

(2009) Stephen Sawcer et al.   ANNALS OF NEUROLOGY

Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study

(2009) W. H. Bos et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapamycin Prevents and Breaks the Anti-CD3-Induced Tolerance in NOD Mice

(2009) A. Valle et al.   DIABETES

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Graves Hyperthyroidism After Stopping Immunosuppressive Therapy in Type 1 Diabetic Islet Cell Recipients With Pretransplant TPO Autoantibodies

(2009) P. Gillard et al.   DIABETES CARE

Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials

(2009) J. De Grijse et al.   DIABETOLOGIA

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells

(2009) Bernadette Pöllinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

(2009) Calliope A Dendrou et al.   NATURE GENETICS

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

(2009) Lisa M. Maier et al.   PLoS Genetics

Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease

(2008) Andreea Ioan-Facsinay et al.   ARTHRITIS AND RHEUMATISM

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient

(2008) J. H. Velthuis et al.   DIABETOLOGIA

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

(2008) Shannon R. Hinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

(2008) Volkert A. L. Huurman et al.   PLoS One