Silica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell Line

High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field

(2015) Cédric Pisani et al.   BMC GENOMICS

Genotoxicity of mesoporous silica nanoparticles in human embryonic kidney 293 cells

(2015) Quanan Zhang et al.   Drug Testing and Analysis

Toxicity of silica nanoparticles depends on size, dose, and cell type

(2015) In-Yong Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Magnetite nanoparticles induced adaptive mechanisms counteract cell death in human pulmonary fibroblasts

(2015) Mihaela Radu et al.   TOXICOLOGY IN VITRO

Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery

(2015) Tatsuya Nakamura et al.   Chemical Science

Theranostic Mesoporous Silica Nanoparticles Biodegrade after Pro-Survival Drug Delivery and Ultrasound/Magnetic Resonance Imaging of Stem Cells

(2015) Paul J. Kempen et al.   Theranostics

Nox NADPH Oxidases and the Endoplasmic Reticulum

(2014) Francisco R.M. Laurindo et al.   ANTIOXIDANTS & REDOX SIGNALING

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice

(2014) Ramin Hassankhani et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Effect of Silica Particle Size on Macrophage Inflammatory Responses

(2014) Toshimasa Kusaka et al.   PLoS One

Intestinal absorption and biological effects of orally administered amorphous silica particles

(2014) Tokuyuki Yoshida et al.   Nanoscale Research Letters

Silica: A lung carcinogen

(2013) Kyle Steenland et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Advanced Oxidation Protein Products Induce Inflammatory Response in Fibroblast-Like Synoviocytes through NADPH Oxidase -Dependent Activation of NF-κB

(2013) Shuai Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Silica nanoparticles-induced cytotoxicity, oxidative stress and apoptosis in cultured A431 and A549 cells

(2013) Maqusood Ahamed   HUMAN & EXPERIMENTAL TOXICOLOGY

Cytotoxicity of silica nanoparticles on HaCaT cells

(2013) Hao Liang et al.   JOURNAL OF APPLIED TOXICOLOGY

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of the size and surface charge of silica nanoparticles on cutaneous toxicity

(2013) Yoon-Hee Park et al.   Molecular & Cellular Toxicology

Recent development of silica nanoparticles as delivery vectors for cancer imaging and therapy

(2013) Xu Wu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

(2013) Junchao Duan et al.   PLoS One

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

(2013) Amruta Manke et al.   Biomed Research International

Interaction of silicon-based quantum dots with gibel carp liver: oxidative and structural modifications

(2013) Loredana Stanca et al.   Nanoscale Research Letters

Role of the Crosstalk between Autophagy and Apoptosis in Cancer

(2013) Minfei Su et al.   Journal of Oncology

Presence of Nano-Sized Silica during In Vitro Digestion of Foods Containing Silica as a Food Additive

(2012) Ruud Peters et al.   ACS Nano

Structural and Oxidative Changes in the Kidney of Crucian Carp Induced by Silicon-Based Quantum Dots

(2012) Sorina Nicoleta Petrache et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

(2012) Haiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer

(2012) M. Kumano et al.   MOLECULAR CANCER THERAPEUTICS

Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif

(2012) Raphaël Beck et al.   PLoS One

Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells

(2012) Isabelle Passagne et al.   TOXICOLOGY

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

(2012) Javed Ahmad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Facile Synthesis of Monodispersed Mesoporous Silica Nanoparticles with Ultralarge Pores and Their Application in Gene Delivery

(2011) Mi-Hee Kim et al.   ACS Nano

Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells

(2011) Blanka Halamoda Kenzaoui et al.   BIOCHEMICAL JOURNAL

Impact of silicon-based quantum dots on the antioxidative system in white muscle of Carassius auratus gibelio

(2011) Loredana Stanca et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation

(2011) Chin-Yi Chen et al.   MITOCHONDRION

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes

(2011) Hiromi Nabeshi et al.   Particle and Fibre Toxicology

Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells

(2011) Yang Li et al.   TOXICOLOGY IN VITRO

Does Vitreous Silica Contradict the Toxicity of the Crystalline Silica Paradigm?

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Proteomic approaches to the characterization of protein thiol modification

(2010) Edward T Chouchani et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells

(2010) Xifei Yang et al.   Particle and Fibre Toxicology

In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: Cyto-, genotoxicity and oxidative stress

(2010) S. Barillet et al.   TOXICOLOGY LETTERS

Ubiquitin-independent p53 proteasomal degradation

(2009) P Tsvetkov et al.   CELL DEATH AND DIFFERENTIATION

In vitro toxicity of silica nanoparticles in myocardial cells

(2009) Yiyi Ye et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

Size Effect on Cell Uptake in Well-Suspended, Uniform Mesoporous Silica Nanoparticles

(2009) Fang Lu et al.   Small

Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells

(2009) Fen Wang et al.   TOXICOLOGY IN VITRO

Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway

(2008) Zhi Jian Guo et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

(2008) Ning Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mesoporous Silica Nanospheres as Highly Efficient MRI Contrast Agents

(2008) Kathryn M. L. Taylor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Macrophage Responses to Silica Nanoparticles are Highly Conserved Across Particle Sizes

(2008) Katrina M. Waters et al.   TOXICOLOGICAL SCIENCES

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS