Nox NADPH Oxidases and the Endoplasmic Reticulum

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells

(2013) Narayana Anilkumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calcium Flashes Orchestrate the Wound Inflammatory Response through DUOX Activation and Hydrogen Peroxide Release

(2013) William Razzell et al.   CURRENT BIOLOGY

Cell Death and Survival Through the Endoplasmic Reticulum- Mitochondrial Axis

(2013) R. Bravo-Sagua et al.   CURRENT MOLECULAR MEDICINE

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

(2013) Edward Avezov et al.   JOURNAL OF CELL BIOLOGY

The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase CIPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF

(2013) Maria Magdalena Drerup et al.   Molecular Plant

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

(2013) A. M. Benham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

NOX5 Expression Is Increased in Intramyocardial Blood Vessels and Cardiomyocytes after Acute Myocardial Infarction in Humans

(2012) Nynke E. Hahn et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Regulation of Ras and Rho GTPases: Mechanism and Function

(2012) Lauren Mitchell et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase

(2012) Chao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Disulfide Isomerase Modification and Inhibition Contribute to ER Stress and Apoptosis Induced by Oxidized Low Density Lipoproteins

(2012) Carole Muller et al.   ANTIOXIDANTS & REDOX SIGNALING

Recombinant Nox4 cytosolic domain produced by a cell or cell-free base systems exhibits constitutive diaphorase activity

(2012) Minh Vu Chuong Nguyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of  3 integrins

(2012) J. Cho et al.   BLOOD

Cleaning Up: ER-Associated Degradation to the Rescue

(2012) Jeffrey L. Brodsky   CELL

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases

(2012) Brian Henderson et al.   CELL STRESS & CHAPERONES

Strategies for identifying synthetic peptides to act as inhibitors of NADPH oxidases, or “All that you did and did not want to know about Nox inhibitory peptides”

(2012) Iris Dahan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Monocyte chemotactic protein-induced protein (MCPIP) promotes inflammatory angiogenesis via sequential induction of oxidative stress, endoplasmic reticulum stress and autophagy

(2012) Arpita Roy et al.   CELLULAR SIGNALLING

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

(2012) Shouji Matsushima et al.   CIRCULATION RESEARCH

Reactive oxygen species generation in fungal development and pathogenesis

(2012) Paul Tudzynski et al.   CURRENT OPINION IN MICROBIOLOGY

The H2O2-sensitive HyPer protein targeted to the endoplasmic reticulum as a mirror of the oxidizing thiol–disulfide milieu

(2012) Ilir Mehmeti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration

(2012) Alicia M. Evangelista et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial compartmentalization of redox processes

(2012) Ariel R. Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein disulfide isomerase in redox cell signaling and homeostasis

(2012) Francisco R.M. Laurindo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production

(2012) M. Jaronen et al.   HUMAN MOLECULAR GENETICS

Role of the NADPH Oxidases in the Subfornical Organ in Angiotensin II–Induced Hypertension

(2012) Heinrich E. Lob et al.   HYPERTENSION

Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice

(2012) Xiucai Xu et al.   INFECTION AND IMMUNITY

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

(2012) Chang Yeop Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation

(2012) Luciana A. Pescatore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish

(2012) Sa Kan Yoo et al.   JOURNAL OF CELL BIOLOGY

ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension

(2012) Colin N. Young et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents

(2012) Reema Jasuja et al.   JOURNAL OF CLINICAL INVESTIGATION

X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2+]i

(2012) Benjamin L. Prosser et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteomic Analysis of Endothelial Lipid Rafts Reveals a Novel Role of Statins in Antioxidation

(2012) Ming-Xia Gu et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative Proteomics Reveals That Only a Subset of the Endoplasmic Reticulum Contributes to the Phagosome

(2012) François-Xavier Campbell-Valois et al.   MOLECULAR & CELLULAR PROTEOMICS

H2O2 Production Downstream of FLT3 Is Mediated by p22phox in the Endoplasmic Reticulum and Is Required for STAT5 Signalling

(2012) John F. Woolley et al.   PLoS One

TLR-4 Signalling Accelerates Colon Cancer Cell Adhesion via NF-κB Mediated Transcriptional Up-Regulation of Nox-1

(2012) D. Peter O'Leary et al.   PLoS One

NOX2β: A Novel Splice Variant of NOX2 That Regulates NADPH Oxidase Activity in Macrophages

(2012) Craig B. Harrison et al.   PLoS One

An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development

(2012) M. A. Hernandez-Onate et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast

(2012) M. Rinnerthaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Rac1 in regulation of NOX5-S function in Barrett's esophageal adenocarcinoma cells

(2011) Jie Hong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Redox-Regulated Peptide Transfer from the Transporter Associated with Antigen Processing to Major Histocompatibility Complex Class I Molecules by Protein Disulfide Isomerase

(2011) Kwangmin Cho et al.   ANTIOXIDANTS & REDOX SIGNALING

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

(2011) Feng Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

The Endoplasmic Reticulum As the Extracellular Space Inside the Cell: Role in Protein Folding and Glycosylation

(2011) Miklós Csala et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress

(2011) Sarah Ullevig et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification

(2011) Marcel Liberman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nox5 Forms a Functional Oligomer Mediated by Self-Association of Its Dehydrogenase Domain

(2011) Tsukasa Kawahara et al.   BIOCHEMISTRY

Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury

(2011) Qing Deng et al.   CELLULAR MICROBIOLOGY

Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation

(2011) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NOX5: from basic biology to signaling and disease

(2011) Karen Bedard et al.   FREE RADICAL BIOLOGY AND MEDICINE

G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction

(2011) B. Hayee et al.   GLYCOBIOLOGY

Activation of NADPH Oxidase 1 Increases Intracellular Calcium and Migration of Smooth Muscle Cells

(2011) Matthew C. Zimmerman et al.   HYPERTENSION

NADPH Oxidase Is Internalized by Clathrin-coated Pits and Localizes to a Rab27A/B GTPase-regulated Secretory Compartment in Activated Macrophages

(2011) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a′

(2011) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4

(2011) Netanya Y. Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized CaMKII causes cardiac sinus node dysfunction in mice

(2011) Paari Dominic Swaminathan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

(2011) Manju Sharma et al.   JOURNAL OF HEPATOLOGY

Inhibition of NADPH oxidase activation by peptides mapping within the dehydrogenase region of Nox2-A “peptide walking” study

(2011) Iris Dahan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Protein disulfide isomerase redox-dependent association with p47phox : evidence for an organizer role in leukocyte NADPH oxidase activation

(2011) Antonio Marcus de A. Paes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation

(2011) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

S-nitrosylation of NADPH oxidase regulates cell death in plant immunity

(2011) Byung-Wook Yun et al.   NATURE

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

(2011) Sa Kan Yoo et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death

(2011) Angélica M. Amanso et al.   PLoS One

Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4

(2011) Q.-A. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

(2011) S. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

Protein Disulfide Isomerase and Host-Pathogen Interaction

(2011) Beatriz S. Stolf et al.   TheScientificWorldJOURNAL

Molecular Mechanisms Regulating Oxidative Activity of the Ero1 Family in the Endoplasmic Reticulum

(2010) Timothy J. Tavender et al.   ANTIOXIDANTS & REDOX SIGNALING

Focal oxidant and Ras signaling on the ER surface activates autophagy

(2010) Ru Feng Wu et al.   Autophagy

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

Constitutive NADPH-Dependent Electron Transferase Activity of the Nox4 Dehydrogenase Domain

(2010) Yukio Nisimoto et al.   BIOCHEMISTRY

New insight into the Nox4 subcellular localization in HEK293 cells: First monoclonal antibodies against Nox4

(2010) Leilei Zhang et al.   BIOCHIMIE

Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure

(2010) N. I. Popescu et al.   BLOOD

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by TGFβ1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat

(2010) XiaoYong Tong et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Deficiency of Rac1 Blocks NADPH Oxidase Activation, Inhibits Endoplasmic Reticulum Stress, and Reduces Myocardial Remodeling in a Mouse Model of Type 1 Diabetes

(2010) Jianmin Li et al.   DIABETES

Intracellular Ca2+can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells

(2010) Monica Lee et al.   FEBS LETTERS

Regulation of NADPH Oxidase Activity in Phagocytes

(2010) Franck Debeurme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early and Late Events Induced by PolyQ-expanded Proteins

(2010) Alessandra Bertoni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nox4 B-loop Creates an Interface between the Transmembrane and Dehydrogenase Domains

(2010) Heather M. Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Relationship between Protein Disulfide Isomerase Family Members during the Oxidative Folding of Human Secretory Proteins

(2010) Lori A. Rutkevich et al.   MOLECULAR BIOLOGY OF THE CELL

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Precursor of Advanced Glycation End Products Mediates ER-Stress-Induced Caspase-3 Activation of Human Dermal Fibroblasts through NAD(P)H Oxidase 4

(2010) Danielle T. Loughlin et al.   PLoS One

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downstream Targets and Intracellular Compartmentalization in Nox Signaling

(2009) Kai Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure

(2009) Denise C. Fernandes et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression and Distribution of NADPH Oxidase Isoforms in Human Myometrium—Role in Angiotensin II-induced Hypertrophy1

(2009) Xiao-Lan Cui et al.   BIOLOGY OF REPRODUCTION

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

Thapsigargin and flavin adenine dinucleotide ex vivo treatment rescues trafficking-defective gp91phox in chronic granulomatous disease leukocytes

(2009) Ya-Fang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages

(2009) Célio X. C. Santos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Role of Protein Disulfide Isomerase in the Regulation of NADPH Oxidase Activity: Pathophysiological Implications in Vascular Diseases

(2008) Francisco R.M. Laurindo et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity

(2008) Ina Helmcke et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling Components of Redox Active Endosomes: The Redoxosomes

(2008) Fredrick D. Oakley et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Control of Platelet Function

(2008) David W. Essex   ANTIOXIDANTS & REDOX SIGNALING

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72

(2008) Wei Chen et al.   BIOCHEMICAL JOURNAL

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

(2008) Philip I. Merksamer et al.   CELL

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol (4,5)-bisphosphate Modulates Nox5 Localization via an N-Terminal Polybasic Region

(2008) Tsukasa Kawahara et al.   MOLECULAR BIOLOGY OF THE CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane

(2008) Jamel El-Benna et al.   Seminars in Immunopathology

The human PDI family: Versatility packed into a single fold

(2007) Christian Appenzeller-Herzog et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Local production of O2− by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation

(2007) Fan Zhang et al.   CELLULAR SIGNALLING

Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl

(2007) Amina El Jamali et al.   FREE RADICAL BIOLOGY AND MEDICINE