Tumor Progression Locus 2 (Tpl2) Kinase as a Novel Therapeutic Target for Cancer: Double-Sided Effects of Tpl2 on Cancer

Tpl2 Inhibitors Thwart Endothelial Cell Function in Angiogenesis and Peritoneal Dissemination

(2015) Wen-Jane Lee et al.   NEOPLASIA

TPL2 kinase regulates the inflammatory milieu of the myeloma niche

(2014) C. Hope et al.   BLOOD

Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

(2014) K. Kim et al.   CARCINOGENESIS

Tpl2 induces castration resistant prostate cancer progression and metastasis

(2014) Hye Won Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions

(2014) Fatema Z. Chowdhury et al.   PLoS One

I B kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases

(2014) A. Ben-Addi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

(2013) Hung-Chuan Pan et al.   CARCINOGENESIS

Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis

(2013) K. L. DeCicco-Skinner et al.   CARCINOGENESIS

Molecular Pathways: Mitogen-Activated Protein Kinase Pathway Mutations and Drug Resistance

(2013) A. L. Pritchard et al.   CLINICAL CANCER RESEARCH

Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma

(2013) H. W. Lee et al.   MOLECULAR CANCER RESEARCH

COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer

(2013) Garam Kim et al.   MOLECULAR CARCINOGENESIS

Altered Prostanoid Signaling Contributes to Increased Skin Tumorigenesis in Tpl2 Knockout Mice

(2013) Kathleen L. DeCicco-Skinner et al.   PLoS One

TPL2 kinase is a suppressor of lung carcinogenesis

(2013) K. Gkirtzimanaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TPL-2/COT AND COX-2 IN BREAST CANCER

(2012) Zuzana Krcova et al.   BIOMEDICAL PAPERS-OLOMOUC

Interleukin-17 induces AP-1 activity and cellular transformation via upregulation of tumor progression locus 2 activity

(2012) G. Kim et al.   CARCINOGENESIS

RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration

(2012) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis

(2012) Vasiliki Koliaraki et al.   JOURNAL OF CLINICAL INVESTIGATION

I B Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

(2012) K. Roget et al.   MOLECULAR AND CELLULAR BIOLOGY

Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice

(2012) Shing Hwa Liu et al.   PLoS One

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

(2012) R. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

(2012) O. B. Serebrennikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

Discovery of indazoles as inhibitors of Tpl2 kinase

(2011) Yonghan Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tpl2 kinase signal transduction in inflammation and cancer

(2011) Maria Vougioukalaki et al.   CANCER LETTERS

Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer

(2011) Petra Schulz et al.   FASEB JOURNAL

Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor- -Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells

(2011) J.-E. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

TPL2/COT/MAP3K8 (TPL2) Activation Promotes Androgen Depletion-Independent (ADI) Prostate Cancer Growth

(2011) Joseph H. Jeong et al.   PLoS One

Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration

(2011) M. Hatziapostolou et al.   Science Signaling

Working Without Kinase Activity: Phosphotransfer-Independent Functions of Extracellular Signal-Regulated Kinases

(2011) J. Rodriguez et al.   Science Signaling

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

(2010) Thorsten Gantke et al.   CELL RESEARCH

Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation

(2010) K. Kakimoto et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis

(2010) K L DeCicco-Skinner et al.   ONCOGENE

Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

(2010) H D Park et al.   ONCOGENE

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-α production

(2009) Kevin Cusack et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma

(2009) Sun A. Kim et al.   CANCER SCIENCE

Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGF

(2009) P. Khanal et al.   CARCINOGENESIS

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Cot/Tpl-2 Protein Kinase as a Target for the Treatment of Inflammatory Disease

(2009) D. George et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells

(2009) Mona Malz et al.   HEPATOLOGY

TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases

(2009) Carmela Rita Balistreri et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

(2009) Frank Kaiser et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice

(2009) Wendy T. Watford et al.   JOURNAL OF IMMUNOLOGY

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1  Production

(2009) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

How Well Do Angiogenesis Inhibitors Work? Biomarkers of Response Prove Elusive

(2009) Vicki Brower   JNCI-Journal of the National Cancer Institute

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

Expression of Toll-like receptor 4 in the prostate gland and its association with the severity of prostate cancer

(2009) Gerardo Gatti et al.   PROSTATE

The versatile role of MSKs in transcriptional regulation

(2009) Linda Vermeulen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis

(2008) S. Hussain et al.   ANGIOGENESIS

NF- B1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

(2008) A. Banerjee et al.   BLOOD

Anti-Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

(2008) J.-H. Egberts et al.   CANCER RESEARCH

Proteinase-Activated Receptor-1-Triggered Activation of Tumor Progression Locus-2 Promotes Actin Cytoskeleton Reorganization and Cell Migration

(2008) M. Hatziapostolou et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

The complexity of mitogen-activated protein kinases (MAPKs) made simple

(2008) M. Krishna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

(2008) Maria Buxade   Frontiers in Bioscience-Landmark

The RSK factors of activating the Ras/MAPK signaling cascade

(2008) Audrey Carriere   Frontiers in Bioscience-Landmark

MSK activation and physiological roles

(2008) J. Simon et al.   Frontiers in Bioscience-Landmark

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF  in LPS-stimulated macrophages

(2008) S. Rousseau et al.   JOURNAL OF CELL SCIENCE

Tpl2 kinase regulates T cell interferon-γ production and host resistance toToxoplasma gondii

(2008) Wendy T. Watford et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Anti-Oxidant, Anti-Inflammatory and Anti-Allergic Activities of Luteolin

(2008) Günter Seelinger et al.   PLANTA MEDICA

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells

(2008) C. Tsatsanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Cells Enhance Tumor Cell Invasion through a Crosstalk Mediated by CXC Chemokine Signaling

(2008) Kristy A. Warner et al.   NEOPLASIA

Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

(2007) Hong Seok Choi et al.   FASEB JOURNAL