Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

(2013) Deborah A. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

TPL-2/COT AND COX-2 IN BREAST CANCER

(2012) Zuzana Krcova et al.   BIOMEDICAL PAPERS-OLOMOUC

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

Microenvironmental Regulation of Epithelial-Mesenchymal Transitions in Cancer

(2012) D. Gao et al.   CANCER RESEARCH

CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer

(2012) Wen-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis

(2012) Vasiliki Koliaraki et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation

(2012) Shing Hwa Liu et al.   JOURNAL OF PATHOLOGY

Calpain/SHP-1 Interaction by Honokiol Dampening Peritoneal Dissemination of Gastric Cancer in nu/nu Mice

(2012) Shing Hwa Liu et al.   PLoS One

p38  and p38  kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

(2012) A. Risco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

(2012) O. B. Serebrennikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro

(2011) Chih-Kang Chiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tpl2 kinase signal transduction in inflammation and cancer

(2011) Maria Vougioukalaki et al.   CANCER LETTERS

Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling

(2011) Yoshihiro Ono et al.   CANCER SCIENCE

Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance

(2011) J. W. Perfield et al.   DIABETES

Unfolded Protein Response Is Required innu/nuMice Microvasculature for Treating Breast Tumor with Tunicamycin

(2011) Aditi Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP-δ regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung cancer through HIF-1α

(2011) Y Min et al.   ONCOGENE

TPL2/COT/MAP3K8 (TPL2) Activation Promotes Androgen Depletion-Independent (ADI) Prostate Cancer Growth

(2011) Joseph H. Jeong et al.   PLoS One

Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells

(2010) O Shinto et al.   BRITISH JOURNAL OF CANCER

Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-γ and COX-2-dependent signals

(2010) Shing Hwa Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NF-κB and AP-1

(2010) Dong Zhang et al.   CANCER BIOLOGY & THERAPY

Targeting ER stress induced apoptosis and inflammation in cancer

(2010) Tom Verfaillie et al.   CANCER LETTERS

p38 maintains E-cadherin expression by modulating TAK1-NF- B during epithelial-to-mesenchymal transition

(2010) R. Strippoli et al.   JOURNAL OF CELL SCIENCE

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis

(2010) K L DeCicco-Skinner et al.   ONCOGENE

Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

(2009) Levi E. Fried et al.   ANTIOXIDANTS & REDOX SIGNALING

Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction

(2009) K. M. Lee et al.   CANCER RESEARCH

Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κB

(2009) Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene

(2008) Yan-Li Li et al.   FEBS Journal

Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis

(2008) Meei Ling Sheu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer

(2008) X-Y Zhong et al.   HISTOPATHOLOGY

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells

(2008) C. Tsatsanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shb Gene Knockdown Increases the Susceptibility of SVR Endothelial Tumor Cells to Apoptotic Stimuli In Vitro and In Vivo

(2007) Nina S. Funa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY