TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Tpl2 Inhibitors Thwart Endothelial Cell Function in Angiogenesis and Peritoneal Dissemination

(2015) Wen-Jane Lee et al.   NEOPLASIA

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms

(2014) S. K. Biswas et al.   JOURNAL OF IMMUNOLOGY

A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma

(2013) Peter M. Voorhees et al.   BRITISH JOURNAL OF HAEMATOLOGY

Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis

(2013) K. L. DeCicco-Skinner et al.   CARCINOGENESIS

Cell plasticity in wound healing: paracrine factors of M1/ M2 polarized macrophages influence the phenotypical state of dermal fibroblasts

(2013) Diana TA Ploeger et al.   Cell Communication and Signaling

Biologic Frontiers in Multiple Myeloma: From Biomarker Identification to Clinical Practice

(2013) O. Landgren et al.   CLINICAL CANCER RESEARCH

Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients

(2013) Berrin Tunca et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

B cell lymphoma and myeloma in murine Gaucher's disease

(2013) EV Pavlova et al.   JOURNAL OF PATHOLOGY

Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

(2013) B A Walker et al.   LEUKEMIA

Macrophages in multiple myeloma: emerging concepts and therapeutic implications

(2013) Fotis Asimakopoulos et al.   LEUKEMIA & LYMPHOMA

Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma

(2013) H. W. Lee et al.   MOLECULAR CANCER RESEARCH

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Tumor-Produced Versican V1 Enhances hCAP18/LL-37 Expression in Macrophages through Activation of TLR2 and Vitamin D3 Signaling to Promote Ovarian Cancer Progression In Vitro

(2013) Dong Li et al.   PLoS One

Characterization of the Toll-like Receptor Expression Profile in Human Multiple Myeloma Cells

(2013) Jahangir Abdi et al.   PLoS One

TPL2 kinase is a suppressor of lung carcinogenesis

(2013) K. Gkirtzimanaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

(2012) M. Chesi et al.   BLOOD

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

(2012) J. B. Egan et al.   BLOOD

Clonal competition with alternating dominance in multiple myeloma

(2012) J. J. Keats et al.   BLOOD

MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages

(2012) Ellen Hebron et al.   BRITISH JOURNAL OF HAEMATOLOGY

Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells

(2012) Jaehyup Kim et al.   BRITISH JOURNAL OF HAEMATOLOGY

Microenvironmental Regulation of Epithelial-Mesenchymal Transitions in Cancer

(2012) D. Gao et al.   CANCER RESEARCH

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Bone Marrow Microenvironment in Multiple Myeloma Progression

(2012) S. Manier et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration

(2012) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis

(2012) Vasiliki Koliaraki et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

(2012) D Kim et al.   LEUKEMIA

Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor–activated macrophages

(2012) Marta López-Pelaéz et al.   MOLECULAR BIOLOGY OF THE CELL

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

(2012) O. B. Serebrennikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple myeloma: 2012 update on diagnosis, risk-stratification, and management

(2011) S. Vincent Rajkumar   AMERICAN JOURNAL OF HEMATOLOGY

The ADAMTS1 Protease Gene Is Required for Mammary Tumor Growth and Metastasis

(2011) Carmela Ricciardelli et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Involvement of Cot activity in the proliferation of ALCL lymphoma cells

(2011) Margarita Fernández et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteoglycan degradation by the ADAMTS family of proteinases

(2011) Heather Stanton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Tpl2 kinase signal transduction in inflammation and cancer

(2011) Maria Vougioukalaki et al.   CANCER LETTERS

From Myeloma Precursor Disease to Multiple Myeloma: New Diagnostic Concepts and Opportunities for Early Intervention

(2011) Ola Landgren et al.   CLINICAL CANCER RESEARCH

Regulators of macrophage activation

(2011) Fernando O. Martinez   EUROPEAN JOURNAL OF IMMUNOLOGY

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

(2011) Marta López-Peláez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gene expression profile of ADAMs and ADAMTSs metalloproteinases in normal and malignant plasma cells and in the bone marrow environment

(2011) Caroline Bret et al.   EXPERIMENTAL HEMATOLOGY

Mouse blood monocytes: Standardizing their identification and analysis using CD115

(2011) W.L. Breslin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

Treatment of multiple myeloma

(2011) S. Vincent Rajkumar   Nature Reviews Clinical Oncology

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAMTS1 Cleavage of Versican Mediates Essential Structural Remodeling of the Ovarian Follicle and Cumulus-Oocyte Matrix During Ovulation in Mice1

(2010) Hannah M. Brown et al.   BIOLOGY OF REPRODUCTION

Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and upregulates p27Kip1concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3

(2010) Xuening Wang et al.   CELL CYCLE

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

(2010) Thorsten Gantke et al.   CELL RESEARCH

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Versican G3 Promotes Mouse Mammary Tumor Cell Growth, Migration, and Metastasis by Influencing EGF Receptor Signaling

(2010) William Weidong Du et al.   PLoS One

Use of Tissue Microarray and Automated Quantitative Analysis for Screening and Validation of Potential Biomarkers in Mantle Cell Lymphoma

(2010) David T. Yang et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Regulation of macrophage function in tumors: the multifaceted role of NF- B

(2009) T. Hagemann et al.   BLOOD

Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis

(2009) Y. Zheng et al.   BLOOD

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression

(2009) Daniel R. McCulloch et al.   DEVELOPMENTAL CELL

Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages

(2009) Jaehyup Kim et al.   EXPERIMENTAL HEMATOLOGY

Tumor Progression Locus 2 (Map3k8) Is Critical for Host Defense against Listeria monocytogenes and IL-1  Production

(2009) L. A. Mielke et al.   JOURNAL OF IMMUNOLOGY

The role of monocytes-macrophages in vasculogenesis in multiple myeloma

(2009) D Ribatti et al.   LEUKEMIA

Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

(2009) John A. Lust et al.   MAYO CLINIC PROCEEDINGS

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

(2009) Shengli Hao et al.   NATURE IMMUNOLOGY

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies

(2008) Marta Chesi et al.   CANCER CELL

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE