Article
Immunology
Li Li, Nianmin Shi, Na Xu, Haibin Wang, Hui Zhao, Haidong Xu, Dawei Liu, Zheng Zhang, Shuping Li, Junnan Zhang, Chunhui Guo, Jinglei Huo, Menghan Zhao, Fengji Luo, Liqing Yang, Yunhua Bai, Qiang Lu, Yusong Zhang, Yi Zhong, Wenhui Gao
Summary: This study evaluated the safety and viral shedding of live attenuated influenza vaccine (LAIV) in Chinese healthy juveniles and adults. The vaccine was well tolerated and not associated with increased rates in adverse reactions or severe adverse events. Phase II study can be carried out as scheduled.
Article
Immunology
M. E. Cole, R. Kundu, A. F. Abdulla, N. Andrews, K. Hoschler, J. Southern, D. Jackson, E. Miller, M. Zambon, P. J. Turner, J. S. Tregoning
Summary: This study analyzed the impact of pre-existing influenza-specific nasal immunoglobulin (Ig)A on the immunogenicity of live attenuated influenza vaccine (LAIV) in children aged 6-14 years. The results showed that baseline nasal IgA levels did not affect the IgG response to the vaccine or the detectability of vaccine virus RNA after immunization. Overall, there was no effect of pre-existing influenza-specific nasal antibody on immunogenicity, supporting annual immunization with LAIV in children.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Pia S. Pannaraj, Andre Guilherme da Costa-Martins, Chiara Cerini, Fan Li, Sook-San Wong, Youvika Singh, Alysson H. Urbanski, Patricia Gonzalez-Dias, Juliana Yang, Richard J. Webby, Helder Nakaya, Grace M. Aldrovandi
Summary: Breastfeeding provides protection against mucosal infections in infants. The study investigated the mechanisms of immune response in human milk following maternal infection with mucosal pathogens. It was found that both live attenuated influenza vaccination (LAIV) and inactivated influenza vaccination (IIV) induced the production of influenza-specific IgA in human milk. However, LAIV resulted in a higher upregulation of innate immunity pathways compared to IIV. This innate immunity in human milk may offer timely protection against mucosal infections in breastfed infants until antigen-specific immunity develops.
MUCOSAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meghan E. Rebuli, Ellen Glista-Baker, Jessica R. Hoffman, Parker F. Duffney, Carole Robinette, Adam M. Speen, Erica A. Pawlak, Radhika Dhingra, Terry L. Noah, Ilona Jaspers
Summary: Inhalation of electronic-cigarette aerosol may cause immune suppression in the respiratory tract, altering immune responses and potentially impacting antiviral host defense functions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, General & Internal
Anand Krishnan, Lalit Dar, Siddhartha Saha, Venkatesh Vinayak Narayan, Rakesh Kumar, Ramesh Kumar, Ritvik Amarchand, Shivram Dhakad, Reshmi Chokker, Avinash Choudekar, Giridara Gopal, Aashish Choudhary, Varsha Potdar, Mandeep Chadha, Kathryn E. Lafond, Stephen Lindstrom, Marc-Alain Widdowson, Seema Jain
Summary: This study conducted a two-year influenza vaccine trial among children aged 2 to 10 years in rural India, finding that LAIV and IIV vaccines were safe and moderately efficacious against influenza virus infection in Indian children.
Article
Biotechnology & Applied Microbiology
Longlong Si, Quan Shen, Jing Li, Li Chen, Jinying Shen, Xue Xiao, Haiqing Bai, Tang Feng, Adam Yongxin Ye, Le Li, Chunhe Zhang, Zhen Li, Ping Wang, Crystal Yuri Oh, Atiq Nurani, Siwen Niu, Chengxin Zhang, Xiaoqiong Wei, Wanqiong Yuan, Hao Liao, Xiaojie Huang, Ning Wang, Wen-xia Tian, Hongwei Tian, Li Li, Xiaoheng Liu, Roberto Plebani
Summary: The study describes the generation of a live attenuated influenza A virus vaccine using PROTAC technology to degrade viral proteins via the host cell's ubiquitin-proteasome system. The vaccine showed highly attenuated and immune responses against both homologous and heterologous virus challenges in mouse and ferret models.
NATURE BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Medicine, Research & Experimental
Beatriz F. Carniel, Fernando Marcon, Jamie Rylance, Esther L. German, Seher Zaidi, Jesus Reine, Edessa Negera, Elissavet Nikolaou, Sherin Pojar, Carla Solorzano, Andrea M. Collins, Victoria Connor, Debby Bogaert, Stephen B. Gordon, Helder Nakaya, Daniela M. Ferreira, Simon P. Jochems, Elena Mitsi
Summary: Summary: This study found that nasal pneumococcal colonization had no impact on antibody response to influenza induced by tetravalent-inactivated influenza vaccine (TIV), but it dampened mucosal antibody response to live attenuated influenza vaccine (LAIV), affecting the efficacy of LAIV. Additionally, the LAIV group showed more apparent pulmonary influenza-specific cellular responses compared to the unvaccinated and TIV groups.
Article
Pediatrics
Andrew G. Sokolow, Amy P. Stallings, Carolyn Kercsmar, Theresa Harrington, Natalia Jimenez-Truque, Yuwei Zhu, Katherine Sokolow, M. Anthony Moody, Elizabeth P. Schlaudecker, Emmanuel B. Walter, Mary Allen Staat, Karen R. Broder, C. Buddy Creech
Summary: This study found that among children with asthma aged 5 to 17 years, LAIV4 was not associated with an increased frequency of asthma exacerbations or asthma-related symptoms compared to IIV4. There were no significant differences in asthma symptoms or lung function changes within 14 days post-vaccination between the two groups.
Article
Medicine, General & Internal
Martina Schneider, Marivic Narciso-Abraham, Sandra Hadl, Robert Mcmahon, Sebastian Toepfer, Ulrike Fuchs, Romana Hochreiter, Annegret Bitzer, Karin Kosulin, Julian Larcher-Senn, Robert Mader, Katrin Dubischar, Oliver Zoihsl, Juan-Carlos Jaramillo, Susanne Eder-Lingelbach, Vera Buerger, Nina Wressnigg
Summary: This study investigated the safety and immunogenicity of the live-attenuated vaccine candidate VLA1553 for chikungunya virus. The results showed that a single dose of VLA1553 induced a strong immune response and generated seroprotective antibody levels in almost all vaccinated participants. The vaccine was well tolerated and had a favorable safety profile.
Article
Critical Care Medicine
Helen Hill, Elena Mitsi, Elissavet Nikolaou, Annie Blizard, Sherin Pojar, Ashleigh Howard, Angela Hyder-Wright, Jack Devin, Jesus Reine, Ryan Robinson, Carla Solorzano, Simon P. Jochems, Tinashe Kenny-Nyazika, Elisa Ramos-Sevillano, Caroline M. Weight, Chris Myerscough, Daniella McLenaghan, Ben Morton, Emily Gibbons, Madlen Farrar, Victoria Randles, Hassan Burhan, Tao Chen, Adam D. Shandling, Joe J. Campo, Robert S. Heyderman, Stephen B. Gordon, Jeremy S. Brown, Andrea M. Collins, Daniela M. Ferreira
Summary: This study investigates the protective effects of nasopharyngeal colonization with attenuated Streptococcus pneumoniae (Spn) strains against re-colonization with wild-type strains. The results indicate that nasal administration of genetically modified live attenuated Spn is safe and induces protection against re-colonization, suggesting it could be an effective strategy for preventing pneumococcal infections.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Yo Han Jang, Baik L. Seong
Summary: Influenza virus infection poses a major public health challenge, with current vaccines potentially compromised by viral antigenic changes. Efforts are underway to develop a universal influenza vaccine that provides long-lasting and broad protection. Immune responses induced by live attenuated influenza vaccines (LAIVs), including neutralizing antibodies, T cell responses, and mucosal immunity, show promising potential for serving as attractive platforms for a universal influenza vaccine.
Article
Medicine, Research & Experimental
Kanta Subbarao
Summary: Live attenuated, cold-adapted influenza vaccines have desirable characteristics, but recent studies have shown reduced replicative fitness of some H1N1pdm09 viruses, affecting the effectiveness of LAIVs. Careful selection of vaccine strains is needed, and a better understanding of replicative fitness and vaccine effectiveness is essential to maximize the potential of these valuable vaccines.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Review
Immunology
Subhan Ullah, Ted M. Ross
Summary: Influenza virus is a major cause of seasonal epidemics and intermittent pandemics. Despite the current molecular biology and vaccine development, influenza virus infection is a significant burden. Vaccines are considered an essential countermeasure for effective control and prevention of influenza virus infection.
EXPERT REVIEW OF VACCINES
(2022)
Article
Biochemical Research Methods
Ji Chen, Jinyu Wang, Hongyu Zhu, Yang Zhang, Jin Sun, Wei Wang, Congwen Wei, Hui Zhong, Mingxin Dong
Summary: Researchers report a novel method to construct recombinant influenza A virus regulated by small molecules. By inserting 4-hydroxytamoxifen (4-HT)-dependent intein into the polymerase acidic (PA) protein of IAV, a series of 4-HT-dependent recombinant viruses were generated and screened. The attenuated viruses showed excellent replication characteristics and elicited robust immunity against homologous viruses.
ACS SYNTHETIC BIOLOGY
(2023)
Letter
Allergy
O. Gorlanova, S. Illi, A. A. Toncheva, J. Usemann, P. Latzin, M. Kabesch, J. -C. Dalphin, R. Lauener, J. R. Pekkanen, E. Von Mutius, J. Riedler, C. E. Kuehni, M. Roosli, U. Frey, Pinelopi Anagnostopoulou, Oliver Fuchs, Insa Korten, Loretta Mueller, Elena Proietti, Anne Schmidt, Anne Hyvarinen, Anne Karvonen, Pirkka Kirjavainen, Sami Remes, Marjut Roponen, Amandine Chauveau, Marie-Laure Dalphin, Vincent Kaulek, Martin Depner, Markus Ege, Jon Genuneit, Georg Loss, Petra Pfefferle, Harald Renz, Bianca Schaub, Charlotte Braun-Fahrlander, Remo Frei, Caroline Roduit, Gert Doekes
Review
Toxicology
Swapna Upadhyay, Lena Palmberg
TOXICOLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Jakob Usemann, Michele Roth, Christoph Bisig, Pierre Comte, Jan Czerwinski, Andreas C. R. Mayer, Philipp Latzin, Loretta Mueller
SCIENTIFIC REPORTS
(2018)
Letter
Respiratory System
Jakob Usemann, Marco P. Alves, Nicole Ritz, Philipp Latzin, Loretta Muller
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Medicine, General & Internal
Loretta Mueller, Sibel T. Savas, Stefan A. Tschanz, Andrea Stokes, Anaies Escher, Mirjam Nussbaumer, Marina Bullo, Claudia E. Kuehni, Sylvain Blanchon, Andreas Jung, Nicolas Regamey, Beat Haenni, Martin Schneiter, Jonas Ingold, Elisabeth Kieninger, Carmen Casaulta, Philipp Latzin
Summary: Primary ciliary dyskinesia (PCD) is a rare genetic disease with respiratory symptoms typically starting at birth. Diagnosing PCD requires a comprehensive approach utilizing methods such as HSVM, IF, TEM, and genetics. PCD-UNIBE in Switzerland is the first comprehensive PCD diagnostic center, offering a thorough diagnostic approach for assessing patients with potential PCD.
Article
Physiology
Loretta Mueller, Jakob Usemann, Marco P. Alves, Philipp Latzin
Summary: Nasal epithelial cells (NECs) exposed to diesel particulate matter (DPM) prior to rhinovirus (RV) infection showed significantly increased viral loads, downregulation of viral defense receptors, upregulation of pro-inflammatory cytokines, indicating a strong interaction between air pollution and the antiviral response to RV infection.
PHYSIOLOGICAL REPORTS
(2021)
Article
Respiratory System
Anais Escher, Elisabeth Kieninger, Susan De Groof, Sibel T. Savas, Martin Schneiter, Stefan A. Tschanz, Martin Frenz, Philipp Latzin, Carmen Casaulta, Loretta Mueller
Summary: This study examined the effects of hypertonic saline (HS), salbutamol, and their combination on the ciliary beating frequency (CBF) and mucociliary transport rate (MCT) in nasal epithelial cells (NECs) of healthy volunteers and patients with cystic fibrosis (CF). The results showed that all tested substances increased CBF and MCT in the NECs, but with different dynamics. HS had a slow and long-lasting effect on CBF, while salbutamol and isotonic saline (IS) had a rapid but short-lived effect.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2023)
Article
Urology & Nephrology
Flavio Vasconcelos Ordones, Lodewikus Vermeulen, Morgan Bressington, Abilash Menon, Timothy Burns, Loretta Muller, Mark Fraundorfer, Peter J. Gilling
Summary: This paper describes the technique used in our institution to perform transperineal prostate biopsy under local anesthetic in the outpatient clinic setting.
CANADIAN JOURNAL OF UROLOGY
(2023)
Article
Respiratory System
Myrofora Goutaki, Leonie Husler, Yin Ting Lam, Helena M. Koppe, Andreas Jung, Romain Lazor, Loretta Mueller, Eva S. L. Pedersen, Claudia E. Kuehni
Summary: This study is the first to describe patient-reported PCD symptoms. The consistent collection of standardized clinical data will allow us to better characterize the phenotypic variability of the disease and study disease course and prognosis.
Article
Respiratory System
Mirjam Nussbaumer, Elisabeth Kieninger, Stefan A. Tschanz, Sibel T. Savas, Carmen Casaulta, Myrofora Goutaki, Sylvain Blanchon, Andreas Jung, Nicolas Regamey, Claudia E. Kuehni, Philipp Latzin, Loretta Muller
Summary: There are significant differences in diagnosis consistency between the algorithms developed by ERS, ATS, and PCD-UNIBE, with 15% of patients having contradictory diagnoses. Further efforts are needed to develop an updated, internationally harmonised, and standardised PCD diagnostic algorithm to improve diagnosis in discordant cases.
Meeting Abstract
Respiratory System
Mirjam Nussbaumer, Elisabeth Kieninger, Stefan A. Tschanz, Sibel T. Savas, Myrofora Goutaki, Claudia E. Kuehni, Sylvain Blanchon, Philipp Latzin, Loretta Muller
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Respiratory System
Anais Escher, Philipp Latzin, Carmen Casaulta, Loretta Muller
EUROPEAN RESPIRATORY JOURNAL
(2021)
Meeting Abstract
Medicine, General & Internal
Loretta Muller, Sibel T. Savas, Stefan Tschanz, Elisabeth Kieninger, Marina Bullo, Carmen Casaulta, Philipp Latzin
SWISS MEDICAL WEEKLY
(2021)
Meeting Abstract
Respiratory System
Jakob Usemann, Marco P. Alves, Nicole Ritz, Philipp Latzin, Loretta Mueller
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Respiratory System
Roland P. Neumann, Markus Hilty, Binbin Xu, Jakob Usemann, Insa Korten, Moana Mika, Loretta Mueller, Philipp Latzin, Urs Frey