Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

(2012) Gero L. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities

(2012) B. S. Hamilton et al.   JOURNAL OF VIROLOGY

Molecular Basis of Efficient Replication and Pathogenicity of H9N2 Avian Influenza Viruses in Mice

(2012) Xiaokang Li et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

New 3-amidinophenylalanine-derived inhibitors of matriptase

(2012) Maya Hammami et al.   MedChemComm

Nephropathogenicity of H9N2 Avian Influenza Virus in Commercial Broiler Chickens Following Intratracheal Inoculation

(2011) M.M. Hadipour et al.   Journal of Animal and Veterinary Advances

H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chicken

(2011) S. Gohrbandt et al.   JOURNAL OF GENERAL VIROLOGY

Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications

(2011) A. Fusaro et al.   JOURNAL OF VIROLOGY

Live Bird Markets of Bangladesh: H9N2 Viruses and the Near Absence of Highly Pathogenic H5N1 Influenza

(2011) Nicholas J. Negovetich et al.   PLoS One

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model

(2011) J. B. Kimble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

(2011) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

(2011) Kosuke Soda et al.   Virology Journal

Endogenous Expression of Matriptase in Neural Progenitor Cells Promotes Cell Migration and Neuron Differentiation

(2010) Jung-Da Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

(2010) S. Bertram et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Modifications to the Hemagglutinin Cleavage Site Control the Virulence of a Neurotropic H1N1 Influenza Virus

(2010) X. Sun et al.   JOURNAL OF VIROLOGY

Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Novel Type II Transmembrane Serine Proteases, MSPL and TMPRSS13, Proteolytically Activate Membrane Fusion Activity of the Hemagglutinin of Highly Pathogenic Avian Influenza Viruses and Induce Their Multicycle Replication

(2010) Y. Okumura et al.   JOURNAL OF VIROLOGY

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

(2010) M. S. Buzza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition

(2009) Jehng-Kang Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides

(2009) François Béliveau et al.   FEBS Journal

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

(2009) C. Chaipan et al.   JOURNAL OF VIROLOGY

Avian influenza infection in birds: A challenge and opportunity for the poultry veterinarian

(2009) I. Capua et al.   POULTRY SCIENCE

Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus

(2009) E. M. Sorrell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

(2009) Eva Böttcher et al.   VACCINE

Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary

(2008) Sine Godiksen et al.   BIOCHEMICAL JOURNAL

Potent Inhibition and Global Co-localization Implicate the Transmembrane Kunitz-type Serine Protease Inhibitor Hepatocyte Growth Factor Activator Inhibitor-2 in the Regulation of Epithelial Matriptase Activity

(2008) Roman Szabo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type II transmembrane serine proteases in development and disease

(2007) R SZABO et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY