Characteristics of human infection with avian influenza viruses and development of new antiviral agents

Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection

(2013) Qiang Liu et al.   ACTA PHARMACOLOGICA SINICA

Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance

(2013) Yunwen Hu et al.   LANCET

Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome

(2013) Yu Chen et al.   LANCET

Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China

(2013) Qi Liu et al.   MICROBES AND INFECTION

Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

(2013) Hai-Nv Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin

(2013) Karunya Srinivasan et al.   PLoS One

Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human

(2013) Jun Li et al.   Science China-Life Sciences

The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA

(2013) Sebastian Maurer-Stroh et al.   Virology Journal

The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks

(2013) Masahiro Kajihara et al.   Virology Journal

An overview of the highly pathogenic H5N1 influenza virus

(2013) Jingchuan Yin et al.   VIROLOGICA SINICA

A new tool to study ribavirin-induced haemolysis

(2012) Etienne Brochot et al.   ANTIVIRAL THERAPY

Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses

(2012) Wolfgang Nacken et al.   BIOLOGICAL CHEMISTRY

New treatments for influenza

(2012) Sailen Barik   BMC Medicine

Introduction

(2012) Simon M. Barratt-Boyes   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly

(2012) Chunfeng Li et al.   FEBS Journal

Clinical use of approved influenza antivirals: therapy and prophylaxis

(2012) Michael G. Ison   Influenza and Other Respiratory Viruses

Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the influenza A virus subtypes responsible for the 20th-century pandemics

(2012) Gunisha Pasricha et al.   Influenza and Other Respiratory Viruses

A Phase II Study of DAS181, a Novel Host Directed Antiviral for the Treatment of Influenza Infection

(2012) R. B. Moss et al.   JOURNAL OF INFECTIOUS DISEASES

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages

(2012) Judith Friesenhagen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

(2012) E. J. A. Schrauwen et al.   JOURNAL OF VIROLOGY

Receptor-Binding Profiles of H7 Subtype Influenza Viruses in Different Host Species

(2012) Alexandra S. Gambaryan et al.   JOURNAL OF VIROLOGY

Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

(2012) J. Verhelst et al.   JOURNAL OF VIROLOGY

Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage

(2012) X. Lu et al.   JOURNAL OF VIROLOGY

Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase

(2012) Kazunori Yamada et al.   MICROBES AND INFECTION

Molecular Basis of Efficient Replication and Pathogenicity of H9N2 Avian Influenza Viruses in Mice

(2012) Xiaokang Li et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

The Potential for Respiratory Droplet-Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host

(2012) C. A. Russell et al.   SCIENCE

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

(2012) Y. Sun et al.   Science Signaling

Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections

(2012) Eva Böttcher-Friebertshäuser et al.   VACCINE

Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

(2012) Matthias Liniger et al.   Virology Journal

A Novel Small Molecule Inhibitor of Influenza A Viruses that Targets Polymerase Function and Indirectly Induces Interferon

(2012) Mila Brum Ortigoza et al.   PLoS Pathogens

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

(2011) Yohichi Kumaki et al.   ANTIVIRAL RESEARCH

Aprotinin and similar protease inhibitors as drugs against influenza

(2011) O.P. Zhirnov et al.   ANTIVIRAL RESEARCH

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

(2011) Karoline Droebner et al.   ANTIVIRAL RESEARCH

IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

(2011) Chenggang Li et al.   CELL RESEARCH

Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling

(2011) Jianhui Ma et al.   Journal of Genetics and Genomics

IL-17 Boosts Proinflammatory Outcome of Antiviral Response in Human Cells

(2011) Grigory Ryzhakov et al.   JOURNAL OF IMMUNOLOGY

Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia

(2011) Diego Viasus et al.   JOURNAL OF INFECTION

H5N1 Influenza Virus–Induced Mediators Upregulate RIG-I in Uninfected Cells by Paracrine Effects Contributing to Amplified Cytokine Cascades

(2011) Kenrie P. Y. Hui et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of an Asparagine-to-Serine Mutation at Position 294 in Neuraminidase on the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus

(2011) M. Kiso et al.   JOURNAL OF VIROLOGY

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

Reversion of PB2-627E to -627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein

(2011) J. Bogs et al.   JOURNAL OF VIROLOGY

Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection

(2011) H. Ma et al.   JOURNAL OF VIROLOGY

A Comparison of Clinical and Epidemiological Characteristics of Fatal Human Infections with H5N1 and Human Influenza Viruses in Thailand, 2004–2006

(2011) Vivek Shinde et al.   PLoS One

Novel Inhibitor Design for Hemagglutinin against H1N1 Influenza Virus by Core Hopping Method

(2011) Xiao-Bo Li et al.   PLoS One

Chinese Herbal Medicines for the Treatment of Type A H1N1 Influenza: A Systematic Review of Randomized Controlled Trials

(2011) Wei Chen et al.   PLoS One

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

(2011) K. B. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity

(2011) Li-Mei Chen et al.   VIROLOGY

Antivirals and resistance: influenza virus

(2011) Michael G Ison   Current Opinion in Virology

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

(2011) Yohei Watanabe et al.   PLoS Pathogens

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

(2011) Mirco Schmolke et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction

(2010) Anna Hing-Yee Law et al.   Cellular & Molecular Immunology

Oseltamivir in human avian influenza infection

(2010) J. R. Smith   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner

(2010) M. P. Walkiewicz et al.   JOURNAL OF GENERAL VIROLOGY

NP Body Domain and PB2 Contribute to Increased Virulence of H5N1 Highly Pathogenic Avian Influenza Viruses in Chickens

(2010) T. Tada et al.   JOURNAL OF VIROLOGY

A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

(2010) G. M. Conenello et al.   JOURNAL OF VIROLOGY

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

(2010) E. Bottcher-Friebertshauser et al.   JOURNAL OF VIROLOGY

Differential Localization and Function of PB1-F2 Derived from Different Strains of Influenza A Virus

(2010) C.-J. Chen et al.   JOURNAL OF VIROLOGY

A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case

(2010) Rongbao Gao et al.   PLoS One

Avian influenza A (H9N2): computational molecular analysis and phylogenetic characterization of viral surface proteins isolated between 1997 and 2009 from the human population

(2010) Azeem M Butt et al.   Virology Journal

DAS181 Inhibits H5N1 Influenza Virus Infection of Human Lung Tissues

(2009) R. W. Y. Chan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Features of Human Influenza A (H5N1) Infection in Vietnam: 2004–2006

(2009) Nguyen Thanh Liem et al.   CLINICAL INFECTIOUS DISEASES

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

(2009) S. Ludwig   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis

(2009) Gallen B. Triana-Baltzer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DAS181 and H5N1 Virus Infection

(2009) Hong Zhang   JOURNAL OF INFECTIOUS DISEASES

Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice

(2009) Y. Matsuoka et al.   JOURNAL OF VIROLOGY

Structure, Receptor Binding, and Antigenicity of Influenza Virus Hemagglutinins from the 1957 H2N2 Pandemic

(2009) R. Xu et al.   JOURNAL OF VIROLOGY

Dating the emergence of pandemic influenza viruses

(2009) Gavin J. D. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2

(2009) Mohamed Rajik et al.   Virology Journal

Evolution analysis of the matrix (M) protein genes of 17 H9N2 chicken influenza viruses isolated in northern China during 1998–2008

(2009) Yanyan Huang et al.   VIRUS GENES

Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans

(2008) Christine Korteweg et al.   AMERICAN JOURNAL OF PATHOLOGY

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

CS-8958, a Prodrug of the New Neuraminidase Inhibitor R-125489, Shows Long-Acting Anti-Influenza Virus Activity

(2008) M. Yamashita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oseltamivir-Ribavirin Combination Therapy for Highly Pathogenic H5N1 Influenza Virus Infection in Mice

(2008) N. A. Ilyushina et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol

(2008) Irina A. Leneva et al.   ANTIVIRAL RESEARCH

Epidemiology of H5N1 avian influenza

(2008) Karen S. Yee et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Arbidol: A Broad-Spectrum Antiviral Compound that Blocks Viral Fusion

(2008) Y. Boriskin et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitory effect of small interfering RNA specific for a novel candidate target in PB1 gene of influenza A virus

(2008) Congsheng Cheng et al.   JOURNAL OF DRUG TARGETING

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Design of a Sialylglycopolymer with a Chitosan Backbone Having Efficient Inhibitory Activity against Influenza Virus Infection

(2008) Myco Umemura et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the Progenitors of Indonesian and Vietnamese Avian Influenza A (H5N1) Viruses from Southern China

(2008) J. Wang et al.   JOURNAL OF VIROLOGY

NP, PB1, and PB2 Viral Genes Contribute to Altered Replication of H5N1 Avian Influenza Viruses in Chickens

(2008) J. L. Wasilenko et al.   JOURNAL OF VIROLOGY

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion

(2008) R. J. Russell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility

(2008) J. A. Belser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging influenza

(2007) Emmie de Wit et al.   JOURNAL OF CLINICAL VIROLOGY

Mutations of neuraminidase implicated in neuraminidase inhibitors resistance

(2007) Olivier Ferraris et al.   JOURNAL OF CLINICAL VIROLOGY