Article
Pharmacology & Pharmacy
Elena A. Govorkova, Emi Takashita, Rod S. Daniels, Seiichiro Fujisaki, Lance D. Presser, Mira C. Patel, Weijuan Huang, Angie Lackenby, Ha T. Nguyen, Dmitriy Pereyaslov, Aine Rattigan, Sook Kwan Brown, Magdi Samaan, Kanta Subbarao, Sun Wong, Dayan Wang, Richard J. Webby, Hui-Ling Yen, Wenqing Zhang, Adam Meijer, Larisa V. Gubareva
Summary: Global analysis showed low susceptibility of influenza viruses to neuraminidase inhibitors (NAIs) and the polymerase acidic (PA) inhibitor baloxavir. NA-H275Y substitution in A(H1N1)pdm09 viruses conferred high resistance to oseltamivir and peramivir. Baloxavir showed reduced susceptibility in a small percentage of viruses, with Japan having a higher rate. Overall, NAIs and baloxavir remain appropriate choices for treating influenza virus infections.
ANTIVIRAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ha T. Nguyen, Anton Chesnokov, Juan De La Cruz, Philippe Noriel Q. Pascua, Vasiliy P. Mishin, Yunho Jang, Joyce Jones, Han Di, Andrei A. Ivashchenko, Mary Lea Killian, Mia K. Torchetti, Kristina Lantz, David E. Wentworth, Charles T. Davis, Alexandre V. Ivachtchenko, Larisa V. Gubareva
Summary: The susceptibility of highly pathogenic avian influenza (HPAI) A(H5N1) viruses to influenza antivirals was evaluated. Among 1,015 sequences collected in the United States in 2022, about 0.8% showed molecular markers of drug resistance. In addition, mutations that may reduce susceptibility to antiviral inhibitors were found in 31 viruses. Close monitoring of drug susceptibility is needed to assess public health risks and inform antiviral stockpiling decisions.
ANTIVIRAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Hui-Xian Wang, Mao-Sen Zeng, Yi Ye, Jin-Yuan Liu, Pei-Ping Xu
Summary: Puerarin, a major isoflavone compound from Pueraria lobata root, exhibits various properties including anti-inflammatory, antioxidant, and antiviral effects. It shows inhibitory activity against H1N1 influenza virus by blocking viral NP transport and newly formed virus particle release. In vivo studies demonstrate its potential as a treatment for influenza virus infection, with effective antiviral activity and reduced inflammation in the lungs.
PHYTOTHERAPY RESEARCH
(2021)
Article
Infectious Diseases
Yanna Guo, Pingyun Ding, Yinjing Li, Yaping Zhang, Yiqing Zheng, Mengqi Yu, Yasuo Suzuki, Haitao Zhang, Jihui Ping
Summary: This study systematically investigated three strains of H10N3 avian influenza virus isolated from live poultry markets and found that these viruses were highly pathogenic to mice, replicated efficiently in mouse nasal turbinate and lungs as well as in A549 cells and chicken embryos, and possessed key molecular markers associated with mammalian adaptation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Pharmacology & Pharmacy
Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong, Elena A. Govorkova
Summary: Effective antivirals play a crucial role in the early phase of an influenza pandemic, before vaccines are available. Currently, two classes of antiviral drugs are approved for influenza treatment, but resistance has been observed. Therefore, it is important to develop novel antiviral options that target both the virus and the host. This review explores the drawbacks of current antivirals and ongoing research on new agents or combination therapies to address these limitations.
ANTIVIRAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sphamadla E. Mtambo, Daniel G. Amoako, Anou M. Somboro, Clement Agoni, Monsurat M. Lawal, Nelisiwe S. Gumede, Rene B. Khan, Hezekiel M. Kumalo
Summary: Influenza viruses (IVs) are known causative agents of respiratory infections and global pandemics in humans, primarily due to their high mutation rates and numerous genomic segments leading to antiviral resistance. Current therapeutic options include vaccines and small molecule inhibitors, but there is a need for continuous development of new anti-influenza therapies targeting the M2 channel and neuraminidase. Further research and development are necessary to design novel inhibitors capable of inhibiting resistant strains.
Article
Chemistry, Medicinal
Avishak Sarker, Zichen Gu, Lu Mao, Yongzhuang Ge, Duoduo Hou, Jieyu Fang, Zhanyong Wei, Zhenya Wang
Summary: Influenza is a century-old disease that poses challenges to humans due to its mutating nature, seasonal epidemics, and occasional pandemics. The limited effectiveness of strain-specific vaccines and the growing drug resistance to anti-influenza drugs call for the development of novel drugs with broad reactivity, higher bioavailability, easier administration, and fewer side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mira C. Patel, Daniel Flanigan, Chenchen Feng, Anton Chesnokov, Ha T. Nguyen, Anwar Abd Elal, John Steel, Rebecca J. Kondor, David E. Wentworth, Larisa V. Gubareva, Vasiliy P. Mishin
Summary: IRINA is a novel influenza virus inhibition assay that measures the enzymatic activity of nascent neuraminidase expressed on virus-infected cells, replacing the traditional immunostaining and imaging procedures. This method can effectively assess the activity of antiviral drugs and antigens, with high throughput capacity and reproducibility.
ANTIVIRAL RESEARCH
(2022)
Article
Chemistry, Medicinal
Yun-Sang Tang, Chao Zhang, Chun-Yeung Lo, Zhe Jin, Bobby Lim-Ho Kong, Meng-Jie Xiao, Er-Fang Huang, Chun Hu, Pang-Chui Shaw
Summary: In this study, a library of analogs of the anti-inflammatory drug Antrafenine was synthesized and tested for their anti-influenza activity. Several compounds showed potent inhibitory effects against different subtypes of influenza viruses, and their action on the ribonucleoprotein (RNP) components was confirmed through experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Erik Skog, Marie Nykvist, Mahmoud M. Naguib, Michelle Wille, Caroline Brojer, Viktoria Agarwal, Patrik Ellstrom, Gabriel Westman, Ake Lundkvist, Josef D. Jarhult
Summary: This study investigates the potential transmission of OC-resistant avian influenza virus from mallards to chickens. The results show that even OC-resistant viruses can spread from ducks to chickens and replicate in chickens. However, these viruses cannot sustain transmission in chickens, likely due to insufficient adaptation to the chicken host.
JOURNAL OF GENERAL VIROLOGY
(2023)
Review
Immunology
Eric J. Chow, Richard H. Beigi, Laura E. Riley, Timothy M. Uyeki
Summary: Early initiation of antiviral treatment of influenza is beneficial in reducing the risk of complications and duration of illness. Pregnant and postpartum women treated with oseltamivir and other neuraminidase inhibitors show reduced risk of severe outcomes with no increase in adverse maternal, fetal, or neonatal outcomes. Baloxavir is not recommended for use in these populations due to lack of safety and efficacy data.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Microbiology
Zhimin Wan, Jianxi Gong, Jianjun Sang, Wenjie Jiang, Zhehong Zhao, Mingjun Lian, Ting Tang, Yafeng Li, Qiuqi Kan, Quan Xie, Tuofan Li, Hongxia Shao, Wei Gao, Aijian Qin, Jianqiang Ye
Summary: In this study, two mouse-adapted H6 avian influenza virus strains were generated and shown to replicate more efficiently and exhibit higher virulence in mice compared to the wild type strains. Genome sequencing revealed several amino acid mutations in the adapted strains, and receptor binding assays and polymerase activity analysis demonstrated increased binding activity and polymerase activity, respectively, in the adapted strains compared to the wild type strains. These findings suggest that H6 avian influenza viruses can acquire amino acid substitutions to adapt to mammals and increase their virulence.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Omnia Kutkat, Ahmed Kandeil, Yassmin Moatasim, Yaseen A. M. M. Elshaier, Wael A. El-Sayed, Samir T. Gaballah, Ahmed El Taweel, Mina Nabil Kamel, Mohamed El Sayes, Mohammed A. Ramadan, Rabeh El-Shesheny, Farouk M. E. Abdel-Megeid, Richard Webby, Ghazi Kayali, Mohamed A. Ali
Summary: This study synthesized novel 1,2,3-triazole glycosides with activity against influenza and tested their antiviral activity in vitro and in vivo. The research found that modifying the glycosyl moiety in the synthesized glycosides enhanced their antiviral activity. Compound 9c showed strong antiviral effects against H1N1 and H5N1, with high binding affinity to neuraminidase.
Article
Virology
Lixiang Xie, Guanlong Xu, Lingxiang Xin, Zhaofei Wang, Rujuan Wu, Mingqing Wu, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jingjiao Ma, Jianhe Sun
Summary: The study demonstrated that the Eurasian avian-like M1 played a more important role than M2 in the pathogenicity of A(H1N1)pdm09 in mice. M1 from H3N2 attenuated the virus in mice, while M2 from H3N2 still maintained virulence. The chimeric virus containing H3N2 M1 induced lower levels of inflammatory cytokines, whereas H3N2 M2 induced substantial pro-inflammatory responses.
Review
Virology
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin
Summary: Hemagglutinin and neuraminidase are critical parts of influenza viruses, serving as targets for immune response and antiviral drugs. Neuraminidase inhibitors like oseltamivir are commonly used against influenza, while antivirals targeting hemagglutinin are newer with a higher resistance threshold.
Review
Immunology
Qiang Liu, Yuan-hong Zhou, Zhan-qiu Yang
CELLULAR & MOLECULAR IMMUNOLOGY
(2016)
Review
Critical Care Medicine
Qiang Liu, Yuan-hong Zhou, Feng Ye, Zhan-qiu Yang
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Article
Oncology
Yuanhong Zhou, Qiang Liu, Xiangchen Dai, Yuling Yan, Ying Yang, Hua Li, Xiaoling Zhou, Wenqi Gao, Xiaolan Li, Zuyang Xi
Article
Chemistry, Multidisciplinary
Qiang Liu, Hai-rong Xiong, Li Lu, Yuan-yuan Liu, Fan Luo, Wei Hou, Zhan-qiu Yang
ACTA PHARMACOLOGICA SINICA
(2013)
Article
Plant Sciences
Qiang Liu, Li Lu, Moli Hua, Yu Xu, Hairong Xiong, Wei Hou, Zhanqiu Yang
JOURNAL OF ETHNOPHARMACOLOGY
(2013)
Editorial Material
Ophthalmology
Liang Liang, Ping Wu
ACTA OPHTHALMOLOGICA
(2020)
Letter
Surgery
Xiaolin Zhou, Yixuan Mou, Jun Zheng, Qiang Liu
ASIAN JOURNAL OF SURGERY
(2020)
Article
Obstetrics & Gynecology
Yuan-hong Zhou, Yan Xie, You-Zhen Luo, Xiao-Wen Liu, Jun Zhou, Qiang Liu
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2020)
Article
Immunology
Anni Li, Xiaolin Zhou, Wei Lu, Yuanhong Zhou, Qiang Liu
IMMUNITY INFLAMMATION AND DISEASE
(2020)
Article
Medicine, General & Internal
Qiang Liu, Na Huang, Anni Li, Yuanhong Zhou, Liang Liang, Xinyu Song, Zhanqiu Yang, Xiaolin Zhou
Summary: In a study involving adults infected with SARS-Cov-2, it was found that patients using low-dose aspirin (100 mg/day) had significantly lower 30-day and 60-day mortality rates compared to those not using aspirin, although there was no significant difference in viral duration between the two groups.
Article
Infectious Diseases
Siyu Gao, Qiang Liu, Xiaolin Zhou, Xiangcheng Dai, HuiQing He
Summary: Primary cutaneous nocardiosis caused by Nocardia farcinica is exceedingly rare, with only six cases reported in the past 15 years. It can be easily overlooked due to lack of characteristic symptoms, leading to fatal consequences. Clinicians should be reminded to consider this disease, especially in patients receiving long-term steroid and cyclophosphamide therapy.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Oncology
Qiang Liu, Xiang-cheng Dai, Xiao-lin Zhou, Feng Ye, Yuan-hong Zhou