New treatments for influenza

Identification of novel conserved functional motifs across most Influenza A viral strains

(2013) Mahmoud ElHefnawi et al.   Virology Journal

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza

(2012) Mark L. Metersky et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Hapivirins and Diprovirins: Novel  -Defensin Analogs with Potent Activity against Influenza A Virus

(2012) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Strain-Specific Contribution of NS1-Activated Phosphoinositide 3-Kinase Signaling to Influenza A Virus Replication and Virulence

(2012) J. Ayllon et al.   JOURNAL OF VIROLOGY

Influenza Virus Sequence Feature Variant Type Analysis: Evidence of a Role for NS1 in Influenza Virus Host Range Restriction

(2012) J. M. Noronha et al.   JOURNAL OF VIROLOGY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Suppression of the antiviral response by an influenza histone mimic

(2012) Ivan Marazzi et al.   NATURE

Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse

(2012) Nicole E. Forbes et al.   PLoS One

Statins in the critically ill

(2012) Isabelle De Loecker et al.   Annals of Intensive Care

Combinatorial Effect of Two Framework Mutations (E119V and I222L) in the Neuraminidase Active Site of H3N2 Influenza Virus on Resistance to Oseltamivir

(2011) Mathilde Richard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

(2011) Ruth Pinto et al.   ANTIVIRAL RESEARCH

The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus

(2011) Mahmoud ElHefnawi et al.   BIOINFORMATICS

Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

(2011) Joseph J. Jablonski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influenza Myocarditis and Myositis: Case Presentation and Review of the Literature

(2011) Kanwal Kumar et al.   CANADIAN JOURNAL OF CARDIOLOGY

Laninamivir octanoate: a new long-acting neuraminidase inhibitor for the treatment of influenza

(2011) Hideyuki Ikematsu et al.   Expert Review of Anti-Infective Therapy

Immunomodulatory therapy for severe influenza

(2011) Ilyse Darwish et al.   Expert Review of Anti-Infective Therapy

Antimicrobial peptides important in innate immunity

(2011) Andreas Cederlund et al.   FEBS Journal

Effect of immunomodulatory therapies in patients with pandemic influenza A (H1N1) 2009 complicated by pneumonia

(2011) Diego Viasus et al.   JOURNAL OF INFECTION

Association Between Use of Statins and Mortality Among Patients Hospitalized With Laboratory-Confirmed Influenza Virus Infections: A Multistate Study

(2011) M. L. Vandermeer et al.   JOURNAL OF INFECTIOUS DISEASES

Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection

(2011) Man To Ling et al.   JOURNAL OF INFECTIOUS DISEASES

Generation and Comprehensive Analysis of an Influenza Virus Polymerase Cellular Interaction Network

(2011) L. Tafforeau et al.   JOURNAL OF VIROLOGY

The Avian Influenza Virus NS1 ESEV PDZ Binding Motif Associates with Dlg1 and Scribble To Disrupt Cellular Tight Junctions

(2011) L. Golebiewski et al.   JOURNAL OF VIROLOGY

Identification of RNA Helicase A as a Cellular Factor That Interacts with Influenza A Virus NS1 Protein and Its Role in the Virus Life Cycle

(2011) L. Lin et al.   JOURNAL OF VIROLOGY

Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor

(2011) Miguel A Mata et al.   Nature Chemical Biology

Influenza A viruses: new research developments

(2011) Rafael A. Medina et al.   NATURE REVIEWS MICROBIOLOGY

Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease

(2011) Stephen J. Brett et al.   PLoS One

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

(2011) K. B. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The host interactome of influenza virus presents new potential targets for antiviral drugs

(2011) Megan L. Shaw   REVIEWS IN MEDICAL VIROLOGY

Emerging cellular targets for influenza antiviral agents

(2011) Konstantin H. Müller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Multiple Organ Invasion by Viruses: Pathological Characteristics in Three Fatal Cases of the 2009 Pandemic Influenza A/H1N1

(2011) Yong-xin Ru et al.   ULTRASTRUCTURAL PATHOLOGY

Systems-Biology Approaches to Discover Anti-Viral Effectors of the Human Innate Immune Response

(2011) Carsten Münk et al.   Viruses-Basel

Fitness of neuraminidase inhibitor-resistant influenza A viruses

(2011) Tatiana Baranovich et al.   Current Opinion in Virology

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

(2011) Christopher J. Vavricka et al.   PLoS Pathogens

Long-Acting Neuraminidase Inhibitor Laninamivir Octanoate (CS-8958) versus Oseltamivir as Treatment for Children with Influenza Virus Infection

(2010) N. Sugaya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis

(2010) Hai-Yan Pan et al.   CARDIOVASCULAR RESEARCH

2009 pandemic H1N1-associated myocarditis in a previously healthy adult

(2010) S. Haessler et al.   CLINICAL MICROBIOLOGY AND INFECTION

Review: Structural determinants of pattern recognition by lung collectins

(2010) Barbara A. Seaton et al.   Innate Immunity

H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response

(2010) D. Viemann et al.   JOURNAL OF IMMUNOLOGY

Dual Resistance to Adamantanes and Oseltamivir Among Seasonal Influenza A(H1N1) Viruses: 2008–2010

(2010) Tiffany G. Sheu et al.   JOURNAL OF INFECTIOUS DISEASES

Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 Protein

(2010) G. A. Versteeg et al.   JOURNAL OF VIROLOGY

Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate

(2010) Nadine Wiesener et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Elimination of a Hydroxyl Group in FTY720 Dramatically Improves the Phosphorylation Rate

(2010) E. Jary et al.   MOLECULAR PHARMACOLOGY

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Cellular targets for influenza drugs

(2010) Ji-Young Min et al.   NATURE BIOTECHNOLOGY

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro

(2010) Jack T. Nguyen et al.   PLoS One

siRNA for Influenza Therapy

(2010) Sailen Barik   Viruses-Basel

Oseltamivir–Resistant Pandemic H1N1/2009 Influenza Virus Possesses Lower Transmissibility and Fitness in Ferrets

(2010) Susu Duan et al.   PLoS Pathogens

Viral aggregating and opsonizing activity in collectin trimers

(2009) Kevan L. Hartshorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus

(2009) Victoria Balannik et al.   BIOCHEMISTRY

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Pulmonary Surfactant: An Immunological Perspective

(2009) Zissis Chroneos et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oseltamivir Resistance and the H274Y Neuraminidase Mutation in Seasonal, Pandemic and Highly Pathogenic Influenza Viruses

(2009) Aeron C. Hurt et al.   DRUGS

Innate immune evasion strategies of influenza viruses

(2009) Benjamin G Hale et al.   Future Microbiology

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

(2009) S. Ludwig   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Essential Impact of NF- B Signaling on the H5N1 Influenza A Virus-Induced Transcriptome

(2009) M. Schmolke et al.   JOURNAL OF IMMUNOLOGY

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

(2009) R. Billharz et al.   JOURNAL OF VIROLOGY

Different Evolutionary Trajectories of European Avian-Like and Classical Swine H1N1 Influenza A Viruses

(2009) E. J. Dunham et al.   JOURNAL OF VIROLOGY

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein

(2009) Gallen B. Triana-Baltzer et al.   PLoS One

T-705 (favipiravir) activity against lethal H5N1 influenza A viruses

(2009) M. Kiso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Emerging antiviral targets for influenza A virus

(2009) Robert M. Krug et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2

(2009) Mohamed Rajik et al.   Virology Journal

Reawakening Retrocyclins: Ancestral Human Defensins Active Against HIV-1

(2009) Nitya Venkataraman et al.   PLOS BIOLOGY

Conventional inactivated bivalent H5/H7 vaccine prevents viral localization in muscles of turkeys infected experimentally with low pathogenic avian influenza and highly pathogenic avian influenza H7N1 isolates

(2008) Anna Toffan et al.   AVIAN PATHOLOGY

Reviews Of Anti‐infective Agents: Maraviroc: The First of a New Class of Antiretroviral Agents

(2008) Rodger D. MacArthur et al.   CLINICAL INFECTIOUS DISEASES

Do we still need the aminoglycosides?

(2008) Emanuele Durante-Mangoni et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids

(2008) K ZHOU et al.   JOURNAL OF BIOTECHNOLOGY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

Update on Avian Influenza A (H5N1) Virus Infection in Humans

(2008)   NEW ENGLAND JOURNAL OF MEDICINE