STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis
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Title
STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis
Authors
Keywords
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Journal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 309, Issue 7, Pages C457-C469
Publisher
American Physiological Society
Online
2015-05-28
DOI
10.1152/ajpcell.00064.2015
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Note: Only part of the references are listed.- Essential role of Orai1 store-operated calcium channels in lactation
- (2015) Felicity M. Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer
- (2015) Christian Holzmann et al. Oncotarget
- Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells
- (2015) Sebastian Schmidt et al. Oncotarget
- Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma
- (2015) Hua Zhu et al. Oncotarget
- Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma
- (2014) Ji-Hee Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma
- (2014) Kateryna Kondratska et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Suppression of stromal interaction molecule 1 inhibits SMMC7721 hepatocellular carcinoma cell proliferation by inducing cell cycle arrest
- (2014) Zhengshan Wu et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer
- (2014) Charlotte Dubois et al. CANCER CELL
- A Reciprocal Shift in Transient Receptor Potential Channel 1 (TRPC1) and Stromal Interaction Molecule 2 (STIM2) Contributes to Ca2+Remodeling and Cancer Hallmarks in Colorectal Carcinoma Cells
- (2014) Diego Sobradillo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leukotriene-C4Synthase, a Critical Enzyme in the Activation of Store-independent Orai1/Orai3 Channels, Is Required for Neointimal Hyperplasia
- (2014) Wei Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STIM1- and Orai1-mediated Ca2+oscillation orchestrates invadopodium formation and melanoma invasion
- (2014) Jianwei Sun et al. JOURNAL OF CELL BIOLOGY
- Store-operated Ca2+ entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation
- (2014) Meng Zhu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Complex role of STIM1 in the activation of store-independent Orai1/3 channels
- (2014) Xuexin Zhang et al. JOURNAL OF GENERAL PHYSIOLOGY
- Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin
- (2014) Manish Singh et al. Nanoscale
- STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression
- (2014) J-Y Wang et al. ONCOGENE
- Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry
- (2014) Hedwig Stanisz et al. Pigment Cell & Melanoma Research
- Store-Operated Ca2+ Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration
- (2014) Masanari Umemura et al. PLoS One
- TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival
- (2014) Maylis Raphaël et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities
- (2014) Kyle J Napier World Journal of Gastrointestinal Oncology
- Inhibition of Orai1-mediated Ca2+ entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle
- (2013) Sarah König et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation?
- (2013) Anne-Sophie Borowiec et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cancer statistics, 2013
- (2013) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Inhibition of store-operated Ca2+ entry suppresses EGF-induced migration and eliminates extravasation from vasculature in nasopharyngeal carcinoma cell
- (2013) Jinyan Zhang et al. CANCER LETTERS
- Microtubule-Associated Histone Deacetylase 6 Supports the Calcium Store Sensor STIM1 in Mediating Malignant Cell Behaviors
- (2013) Y.-T. Chen et al. CANCER RESEARCH
- Exploring the unique features of the ARC channel, a Store-independent Orai channel
- (2013) Jill L Thompson et al. Channels
- Emerging roles of Orai3 in pathophysiology
- (2013) Rajender K Motiani et al. Channels
- Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC 4
- (2013) José C. González-Cobos et al. CIRCULATION RESEARCH
- STIM1 and STIM2-mediated Ca2+influx regulates antitumour immunity by CD8+T cells
- (2013) Carl Weidinger et al. EMBO Molecular Medicine
- The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1
- (2013) Wenjun Li et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
- Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest
- (2013) Guilin Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels
- (2013) X. Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
- STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion
- (2013) Rajender K. Motiani et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- SPCA2 Regulates Orai1 Trafficking and Store Independent Ca2+ Entry in a Model of Lactation
- (2013) Brandie M. Cross et al. PLoS One
- Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation
- (2013) Anne-Sophie Ay et al. PLoS One
- STIM1 Controls Endothelial Barrier Function Independently of Orai1 and Ca2+ Entry
- (2013) A. V. Shinde et al. Science Signaling
- Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells
- (2012) Junko Yoshida et al. BIOCHEMICAL PHARMACOLOGY
- ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells
- (2012) Malika Faouzi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Store-operated Ca2+ entry in proliferating and retinoic acid-differentiated N- and S-type neuroblastoma cells
- (2012) Natalie Bell et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover
- (2012) Ning Yang et al. CANCER LETTERS
- Lipid rafts couple store-operated Ca 2+ entry to constitutive activation of PKB/Akt in a Ca 2+ /calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth
- (2012) Shlomit Fedida-Metula et al. CARCINOGENESIS
- Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis
- (2012) Rajender K. Motiani et al. FASEB JOURNAL
- Calcium Channels and Pumps in Cancer: Changes and Consequences
- (2012) Gregory R. Monteith et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STIM proteins: dynamic calcium signal transducers
- (2012) Jonathan Soboloff et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development
- (2012) H Peng et al. ONCOGENE
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- (2012) Felicity M. Davis et al. PLoS One
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- (2012) Francesco Lodola et al. PLoS One
- Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells
- (2011) Jiajia Hu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2011) Ming-Feng Hou et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells
- (2011) Suxia Sun et al. BIOSCIENCE REPORTS
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
- (2011) Jaw-Yuan Wang et al. CELLULAR SIGNALLING
- Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation
- (2011) Jing Li et al. CIRCULATION RESEARCH
- Oleic acid inhibits store-operated calcium entry in human colorectal adenocarcinoma cells
- (2011) Celia Carrillo et al. EUROPEAN JOURNAL OF NUTRITION
- Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis
- (2011) Huiling Liu et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- STIM and Orai proteins and the non-capacitative ARC channels
- (2011) Trevor et al. Frontiers in Bioscience-Landmark
- Transient Receptor Potential Canonical Channels Are Required forin VitroEndothelial Tube Formation
- (2011) Fabrice Antigny et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca2+-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria
- (2011) Eva Muñoz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glioblastoma survival in the United States before and during the temozolomide era
- (2011) Derek R. Johnson et al. JOURNAL OF NEURO-ONCOLOGY
- Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca2+ Influx through Plasma Membrane Ca2+ Channels
- (2011) N. Yanamandra et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer
- (2011) D. McAndrew et al. MOLECULAR CANCER THERAPEUTICS
- Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis
- (2011) Y.-F. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vascular Endothelial Growth Factor Stimulates Endothelial Colony Forming Cells Proliferation and Tubulogenesis by Inducing Oscillations in Intracellular Ca2+ Concentration
- (2011) Silvia Dragoni et al. STEM CELLS
- Inhibition of store-operated Ca2+ channels prevent ethanol-induced intracellular Ca2+ increase and cell injury in a human hepatoma cell line
- (2011) Huimin Liu et al. TOXICOLOGY LETTERS
- Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration
- (2010) Jonathan M. Bisaillon et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
- (2010) Mingye Feng et al. CELL
- Coupling of mitochondria to store-operated Ca2+-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells
- (2010) Ben Feldman et al. CELL CALCIUM
- A Novel Native Store-operated Calcium Channel Encoded by Orai3
- (2010) Rajender K. Motiani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells
- (2010) Malika Faouzi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels
- (2010) C. Y. Park et al. SCIENCE
- The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels
- (2010) Y. Wang et al. SCIENCE
- Store-Operated Ca2+ Entry Is Expressed in Human Endothelial Progenitor Cells
- (2010) Yuly Sánchez-Hernández et al. STEM CELLS AND DEVELOPMENT
- Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells
- (2010) M Flourakis et al. Cell Death & Disease
- A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels
- (2009) Takumi Kawasaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis
- (2009) Shengyu Yang et al. CANCER CELL
- STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
- (2009) Chan Young Park et al. CELL
- A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels
- (2009) Martin Muik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SOAR and the polybasic STIM1 domains gate and regulate Orai channels
- (2009) Joseph P. Yuan et al. NATURE CELL BIOLOGY
- Store-operated cyclic AMP signalling mediated by STIM1
- (2009) Konstantinos Lefkimmiatis et al. NATURE CELL BIOLOGY
- Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture
- (2008) Roberto Berra-Romani et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Cancer Statistics, 2008
- (2008) A. Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
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- (2008) S. Fedida-Metula et al. CARCINOGENESIS
- Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation
- (2008) Iskandar F. Abdullaev et al. CIRCULATION RESEARCH
- STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER
- (2008) Ilya Grigoriev et al. CURRENT BIOLOGY
- Overexpression of bax induces down-regulation of store-operated calcium entry in prostate cancer cells
- (2008) Na Li et al. JOURNAL OF CELLULAR PHYSIOLOGY
- STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction
- (2008) Weizhong Zeng et al. MOLECULAR CELL
- The epidemiology of neuroblastoma: a review
- (2008) Julia E. Heck et al. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
- Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels
- (2007) Olivier Mignen et al. JOURNAL OF PHYSIOLOGY-LONDON
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