Leukotriene-C4Synthase, a Critical Enzyme in the Activation of Store-independent Orai1/Orai3 Channels, Is Required for Neointimal Hyperplasia

Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells

(2014) Sung Ji Yun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

(2014) Xuexin Zhang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery

(2014) Wei Zhang et al.   Jove-Journal of Visualized Experiments

Exploring the unique features of the ARC channel, a Store-independent Orai channel

(2013) Jill L Thompson et al.   Channels

Emerging roles of Orai3 in pathophysiology

(2013) Rajender K Motiani et al.   Channels

Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC 4

(2013) José C. González-Cobos et al.   CIRCULATION RESEARCH

A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid

(2013) Hideo Ago et al.   JOURNAL OF BIOCHEMISTRY

Crystal Structures of Leukotriene C4Synthase in Complex with Product Analogs

(2013) Damian Niegowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of STIM1 Activation of Store-Independent Leukotriene C4-Regulated Ca2+ Channels

(2013) X. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

(2013) Rajender K. Motiani et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

STIM1 Controls Endothelial Barrier Function Independently of Orai1 and Ca2+ Entry

(2013) A. V. Shinde et al.   Science Signaling

Capacitative and non-capacitative signaling complexes in human platelets

(2012) Alejandro Berna-Erro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AKT2 Confers Protection Against Aortic Aneurysms and Dissections

(2012) Ying H. Shen et al.   CIRCULATION RESEARCH

Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle

(2012) Salvatore Mancarella et al.   FASEB JOURNAL

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration

(2012) Amy M. Spinelli et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Stim1- and Orai1-mediated store-operated calcium entry is critical for angiotensin II-induced vascular smooth muscle cell proliferation

(2011) Rui-wei Guo et al.   CARDIOVASCULAR RESEARCH

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Orai1-Mediated I CRAC Is Essential for Neointima Formation After Vascular Injury

(2011) Wei Zhang et al.   CIRCULATION RESEARCH

Mislocalization of the E3 Ligase, β-Transducin Repeat-containing Protein 1 (β-TrCP1), in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1) and Akt

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase (PHLPP): A New Player in Cell Signaling

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

(2010) Jonathan M. Bisaillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-Dependent Regulation of PHLPP Expression Controls the Rapamycin Sensitivity in Cancer Cells

(2010) Jianyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

(2010) A. Di Gennaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration

(2009) Marie Potier et al.   FASEB JOURNAL

Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals

(2009) Jacob J. Freiberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture

(2008) Roberto Berra-Romani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Promotor Polymorphisms in Leukotriene C 4 Synthase and Risk of Ischemic Cerebrovascular Disease

(2008) Jacob J. Freiberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An essential role for stromal interaction molecule 1 in neointima formation following arterial injury

(2008) Rui-Wei Guo et al.   CARDIOVASCULAR RESEARCH

Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

(2008) Iskandar F. Abdullaev et al.   CIRCULATION RESEARCH

RNA Interference Targeting STIM1 Suppresses Vascular Smooth Muscle Cell Proliferation and Neointima Formation in the Rat

(2008) Fleur C Aubart et al.   MOLECULAR THERAPY

The cysteinyl leukotrienes: Where do they come from? What are they? Where are they going?

(2008) K Frank Austen   NATURE IMMUNOLOGY

Leukotrienes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease

(2008) Suzanne J. House et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetic Variation in Members of the Leukotriene Biosynthesis Pathway Confer an Increased Risk of Ischemic Stroke

(2008) Steve Bevan et al.   STROKE

Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

(2007) A W Y Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY