Exploring the unique features of the ARC channel, a Store-independent Orai channel

Molecular basis of activation of the arachidonate-regulated Ca2+(ARC) channel, a store-independent Orai channel, by plasma membrane STIM1

(2013) Jill L. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

(2013) S. Bandara et al.   Science Signaling

How Many Orai's Does It Take to Make a CRAC Channel?

(2013) Jill L. Thompson et al.   Scientific Reports

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations

(2011) Jill L. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Basic Sequence in STIM1 Promotes Ca2+Influx by Interacting with the C-Terminal Acidic Coiled Coil of Orai1

(2010) Nathaniel Calloway et al.   BIOCHEMISTRY

The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid

(2010) Jill Thompson et al.   Channels

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells

(2010) Josef Madl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

CRAC channelopathies

(2010) Stefan Feske   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Ribosome-free Terminals of Rough ER Allow Formation of STIM1 Puncta and Segregation of STIM1 from IP3 Receptors

(2009) Gyorgy Lur et al.   CURRENT BIOLOGY

Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain

(2009) Yuusuke Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits

(2009) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

(2009) L. Orci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Functional stoichiometry of the unitary calcium-release-activated calcium channel

(2008) W. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON