Lipid rafts couple store-operated Ca 2+ entry to constitutive activation of PKB/Akt in a Ca 2+ /calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth

Activation of the PI3K/Akt signaling pathway through P2Y2 receptors by extracellular ATP is involved in osteoblastic cell proliferation

(2011) Sebastián Katz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells

(2011) Ming-Feng Hou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression

(2011) K. H. T. Paraiso et al.   CANCER RESEARCH

Histamine regulates cyclooxygenase 2 gene activation through Orai1-mediated NFκB activation in lung cancer cells

(2011) Wan-Chen Huang et al.   CELL CALCIUM

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells

(2011) Jaw-Yuan Wang et al.   CELLULAR SIGNALLING

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

(2011) C H Switzer et al.   ONCOGENE

Store-Operated Calcium Channels: New Perspectives on Mechanism and Function

(2011) R. S. Lewis   Cold Spring Harbor Perspectives in Biology

Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFκB activation via Src-dependent blockade of PP2A

(2010) Sandra Barisic et al.   BIOCHEMICAL PHARMACOLOGY

Lipid rafts modulate the activation but not the maintenance of store-operated Ca2+ entry

(2010) Carmen Galan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

(2010) Y. Shao et al.   CANCER RESEARCH

Coupling of mitochondria to store-operated Ca2+-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells

(2010) Ben Feldman et al.   CELL CALCIUM

MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720

(2010) C. C. Jiang et al.   CLINICAL CANCER RESEARCH

Ganglioside GD3 Enhances Adhesion Signals and Augments Malignant Properties of Melanoma Cells by Recruiting Integrins to Glycolipid-enriched Microdomains

(2010) Yuki Ohkawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NCAM-Induced Neurite Outgrowth Depends on Binding of Calmodulin to NCAM and on Nuclear Import of NCAM and fak Fragments

(2010) R. Kleene et al.   JOURNAL OF NEUROSCIENCE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells

(2010) K-F Chen et al.   ONCOGENE

The Rafts of the Medusa: cholesterol targeting in cancer therapy

(2010) M R Freeman et al.   ONCOGENE

Weekly Cyclodextrin Administration Normalizes Cholesterol Metabolism in Nearly Every Organ of the Niemann-Pick Type C1 Mouse and Markedly Prolongs Life

(2010) Charina M Ramirez et al.   PEDIATRIC RESEARCH

Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia

(2009) Xiaohan Hu et al.   BMC NEUROSCIENCE

NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma

(2009) R J Flockhart et al.   BRITISH JOURNAL OF CANCER

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

(2009) M. A. Davies et al.   CLINICAL CANCER RESEARCH

Calmodulin-mediated regulation of the epidermal growth factor receptor

(2009) Pablo Sánchez-González et al.   FEBS Journal

Cholesterol depletion induces anoikis‐like apoptosis via FAK down‐regulation and caveolae internalization

(2009) Eun‐Kyung Park et al.   JOURNAL OF PATHOLOGY

Impaired Cholesterol Biosynthesis in a Neuronal Cell Line Persistently Infected with Measles Virus

(2009) S. Robinzon et al.   JOURNAL OF VIROLOGY

Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma

(2009) Jade Homsi et al.   MELANOMA RESEARCH

Akt/Protein Kinase B and Glycogen Synthase Kinase-3  Signaling Pathway Regulates Cell Migration through the NFAT1 Transcription Factor

(2009) M. Yoeli-Lerner et al.   MOLECULAR CANCER RESEARCH

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

(2009) SubbaRao V. Madhunapantula et al.   Pigment Cell & Melanoma Research

A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry

(2009) Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

(2009) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MS4A12 Is a Colon-Selective Store-Operated Calcium Channel Promoting Malignant Cell Processes

(2008) M. Koslowski et al.   CANCER RESEARCH

Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development

(2008) M. Cheung et al.   CANCER RESEARCH

Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells

(2008) S. Fedida-Metula et al.   CARCINOGENESIS

Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation

(2008) Charbel El Boustany et al.   HEPATOLOGY

Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+Entry (SOCE)

(2008) Biswaranjan Pani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5

(2008) J. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of membrane rafts of melanoma cells identifies protein patterns characteristic of the tumor progression stage

(2008) Frédérique Baruthio et al.   PROTEOMICS

Multiple pathways regulated by the tumor suppressor PP2A in transformation

(2008) Jukka Westermarck et al.   TRENDS IN MOLECULAR MEDICINE