Emerging roles of Orai3 in pathophysiology

Store-Independent Orai1/3 Channels Activated by Intracrine LeukotrieneC 4

(2013) José C. González-Cobos et al.   CIRCULATION RESEARCH

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

(2012) Malika Faouzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel

(2012) Jill L. Thompson et al.   Channels

Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle

(2012) Salvatore Mancarella et al.   FASEB JOURNAL

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Orai channels - New insights, new ideas

(2012) Trevor J. Shuttleworth   JOURNAL OF PHYSIOLOGY-LONDON

Targeted Polymersome Delivery of siRNA Induces Cell Death of Breast Cancer Cells Dependent upon Orai3 Protein Expression

(2012) Todd O. Pangburn et al.   LANGMUIR

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Glu106in the Orai1 pore contributes to fast Ca2+-dependent inactivation and pH dependence of Ca2+release-activated Ca2+(CRAC) current

(2011) Nathan R. Scrimgeour et al.   BIOCHEMICAL JOURNAL

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

(2011) F.R. Giachini et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Orai1-Mediated I CRAC Is Essential for Neointima Formation After Vascular Injury

(2011) Wei Zhang et al.   CIRCULATION RESEARCH

STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats

(2011) Fernanda R. C. Giachini et al.   CLINICAL SCIENCE

STIM and Orai proteins and the non-capacitative ARC channels

(2011) Trevor et al.   Frontiers in Bioscience-Landmark

Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

(2011) Salvatore Mancarella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tipifarnib-Induced Apoptosis in Acute Myeloid Leukemia and Multiple Myeloma Cells Depends on Ca2+ Influx through Plasma Membrane Ca2+ Channels

(2011) N. Yanamandra et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 and Orai1: novel targets for vascular diseases?

(2011) Wei Zhang et al.   Science China-Life Sciences

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

(2010) Jonathan M. Bisaillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid

(2010) Jill Thompson et al.   Channels

Immunodeficiency due to mutations in ORAI1 and STIM1

(2010) Stefan Feske et al.   CLINICAL IMMUNOLOGY

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Store-Operated Ca2+ Entry through ORAI1 Is Critical for T Cell-Mediated Autoimmunity and Allograft Rejection

(2010) C.-A. McCarl et al.   JOURNAL OF IMMUNOLOGY

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

(2010) I. Bogeski et al.   Science Signaling

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

Breast Cancer, Estrogen Receptor and Ligands

(2009) Zhenlin Bai et al.   ARCHIV DER PHARMAZIE

Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways

(2009) Yassine El Hiani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

Arachidonic acid, ARC channels, and Orai proteins

(2009) Trevor J. Shuttleworth   CELL CALCIUM

Extracellular Signal-Regulated Kinases 1 and 2 and TRPC1 Channels are Required for Calcium-Sensing Receptor-Stimulated MCF-7 Breast Cancer Cell Proliferation

(2009) Yassine El Hiani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration

(2009) Marie Potier et al.   FASEB JOURNAL

The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits

(2009) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM1Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

(2009) Capucine Picard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

(2009) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

(2009) F. M. Mullins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture

(2008) Roberto Berra-Romani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An essential role for stromal interaction molecule 1 in neointima formation following arterial injury

(2008) Rui-Wei Guo et al.   CARDIOVASCULAR RESEARCH

Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

(2008) Iskandar F. Abdullaev et al.   CIRCULATION RESEARCH

Store-dependent and -independent Modes Regulating Ca2+Release-activated Ca2+Channel Activity of Human Orai1 and Orai3

(2008) Shenyuan L. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

(2008) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of TRPV6 in breast carcinogenesis

(2008) K. A. Bolanz et al.   MOLECULAR CANCER THERAPEUTICS

RNA Interference Targeting STIM1 Suppresses Vascular Smooth Muscle Cell Proliferation and Neointima Formation in the Rat

(2008) Fleur C Aubart et al.   MOLECULAR THERAPY

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

The non-excitable smooth muscle: Calcium signaling and phenotypic switching during vascular disease

(2008) Suzanne J. House et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON