Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis

Upholding a role for EMT in breast cancer metastasis

(2017) Xin Ye et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer

(2017) Yi-Fang Tsai et al.   PLoS One

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

(2017) Heather J. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

(2017) Yukari Okita et al.   Science Signaling

LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer

(2017) Sul Ki Choi et al.   Oncotarget

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

(2017) Christiana Polydorou et al.   Oncotarget

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

(2017) Yukari Okita et al.   Science Signaling

MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells

(2017) C Rattanasinchai et al.   Oncogenesis

Breast Cancer

(2017) Robert W. Carlson et al.   Journal of the National Comprehensive Cancer Network

Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triple-negative breast cancer

(2017) Jun Tian et al.   Scientific Reports

Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

(2017) Panagiotis Papageorgis et al.   Scientific Reports

Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis

(2017) Tieying Dong et al.   Scientific Reports

Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer

(2016) Maria Cristina Rangel et al.   BREAST CANCER RESEARCH AND TREATMENT

PTK6 Inhibition Suppresses Metastases of Triple-Negative Breast Cancer via SNAIL-Dependent E-Cadherin Regulation

(2016) K. Ito et al.   CANCER RESEARCH

Inflammation Triggers Zeb1-Dependent Escape from Tumor Latency

(2016) Jasmine M. De Cock et al.   CANCER RESEARCH

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer

(2016) A Blomme et al.   ONCOGENE

Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells

(2016) K Tominaga et al.   ONCOGENE

SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis

(2016) Sait Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer

(2016) Marzia A. Locatelli et al.   Oncotarget

ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis

(2016) Simone Di Franco et al.   Oncotarget

Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells

(2016) Hanna Taipaleenmäki et al.   Oncotarget

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

(2016) Ken Takai et al.   Oncotarget

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

(2016) Jinkyoung Kim et al.   Oncotarget

Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype

(2016) Qing He et al.   Scientific Reports

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection

(2016) Brian D. Lehmann et al.   PLoS One

Role of epithelial–mesenchymal transition markers in triple-negative breast cancer

(2015) Sai Yin Cheung et al.   BREAST CANCER RESEARCH AND TREATMENT

SSBP1 Suppresses TGF -Driven Epithelial-to-Mesenchymal Transition and Metastasis in Triple-Negative Breast Cancer by Regulating Mitochondrial Retrograde Signaling

(2015) H.-L. Jiang et al.   CANCER RESEARCH

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

(2015) M. W. Nasser et al.   CANCER RESEARCH

Expression of epithelial-mesenchymal transition–related markers in triple-negative breast cancer: ZEB1 as a potential biomarker for poor clinical outcome

(2015) Min Hye Jang et al.   HUMAN PATHOLOGY

Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells

(2015) A. W. Lambert et al.   MOLECULAR CANCER RESEARCH

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

(2015) Liangliang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

(2015) Zhen Ning Wee et al.   Nature Communications

MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer

(2015) De Chen et al.   Oncotarget

Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-β/SMAD signaling

(2015) Hong-Lin Jiang et al.   Oncotarget

Remodeling Components of the Tumor Microenvironment to Enhance Cancer Therapy

(2015) Vasiliki Gkretsi et al.   Frontiers in Oncology

Rad51 supports triple negative breast cancer metastasis.

(2015) Adrian P. Wiegmans et al.   Oncotarget

ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling

(2015) Tetsuro Masuda et al.   Scientific Reports

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Slug Promotes Survival during Metastasis through Suppression of Puma-Mediated Apoptosis

(2014) S. Kim et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis

(2014) A Paul et al.   CELL DEATH AND DIFFERENTIATION

Osteopontin mediates an MZF1–TGF-β1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer

(2014) C E Weber et al.   ONCOGENE

Suppression of Invasion and Metastasis of Triple-Negative Breast Cancer Lines by Pharmacological or Genetic Inhibition of Slug Activity

(2014) Giovanna Ferrari-Amorotti et al.   NEOPLASIA

The Emerging Role of the Molecular Diagnostics Laboratory in Breast Cancer Personalized Medicine

(2013) Francine B. De Abreu et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt signaling in triple negative breast cancer is associated with metastasis

(2013) Nandini Dey et al.   BMC CANCER

Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells

(2013) Molly A. Taylor et al.   BREAST CANCER RESEARCH AND TREATMENT

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Phase II Trial of Bicalutamide in Patients with Androgen Receptor-Positive, Estrogen Receptor-Negative Metastatic Breast Cancer

(2013) A. Gucalp et al.   CLINICAL CANCER RESEARCH

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

(2013) Diana J. Azzam et al.   EMBO Molecular Medicine

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Targeting triple-negative breast cancer: optimising therapeutic outcomes

(2012) K. Gelmon et al.   ANNALS OF ONCOLOGY

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

MLK3 Regulates Paxillin Phosphorylation in Chemokine-Mediated Breast Cancer Cell Migration and Invasion to Drive Metastasis

(2012) Jian Chen et al.   CANCER RESEARCH

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Comparative proteome profiling of breast tumor cell lines by gel electrophoresis and mass spectrometry reveals an epithelial mesenchymal transition associated protein signature

(2012) Daniele Vergara et al.   Molecular BioSystems

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs

(2011) Qing Chen et al.   CANCER CELL

S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways

(2011) M. W. Nasser et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Heterogeneity in breast cancer

(2011) Kornelia Polyak   JOURNAL OF CLINICAL INVESTIGATION

TIEG1 Inhibits Breast Cancer Invasion and Metastasis by Inhibition of Epidermal Growth Factor Receptor (EGFR) Transcription and the EGFR Signaling Pathway

(2011) W. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61

(2011) L G Harris et al.   ONCOGENE

Molecular Stratification of Triple-Negative Breast Cancers

(2011) C. M. Perou   ONCOLOGIST

Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated Molecules

(2011) Monther Al-Alwan et al.   PLoS One

The Transcription Factors Snail and Slug Activate the Transforming Growth Factor-Beta Signaling Pathway in Breast Cancer

(2011) Archana Dhasarathy et al.   PLoS One

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triple negative breast cancer - prognostic factors and survival

(2011) Tanja Ovcaricek et al.   Radiology and Oncology

Targeting Fibroblast Growth Factor Receptors Blocks PI3K/AKT Signaling, Induces Apoptosis, and Impairs Mammary Tumor Outgrowth and Metastasis

(2010) J. H. Dey et al.   CANCER RESEARCH

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

Triple-negative breast cancer: Molecular features, pathogenesis, treatment and current lines of research

(2010) Ana Bosch et al.   CANCER TREATMENT REVIEWS

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

Migrastatin analogues target fascin to block tumour metastasis

(2010) Lin Chen et al.   NATURE

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Role of biologic therapy and chemotherapy in hormone receptor- and HER2-positive breast cancer

(2009) A. U. Buzdar   ANNALS OF ONCOLOGY

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactions

(2009) Jane Wenzel et al.   CLINICAL & EXPERIMENTAL METASTASIS

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer

(2009) Carey K. Anders et al.   Clinical Breast Cancer

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

(2009) Derek M. Dykxhoorn et al.   PLoS One

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Are Triple-Negative and Basal-Like Breast Cancer Synonymous?

(2008) E. Rakha et al.   CLINICAL CANCER RESEARCH

RNA Aptamer Blockade of Osteopontin Inhibits Growth and Metastasis of MDA-MB231 Breast Cancer Cells

(2008) Zhiyong Mi et al.   MOLECULAR THERAPY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY