Article
Cell Biology
Pei-Yi Lin, Z. Zack Ma, Melissa Mahgoub, Ege T. Kavalali, Lisa M. Monteggia
Summary: Ketamine's rapid antidepressant action is dependent on BDNF-TrkB signaling in CA1 neurons and a specific synaptic locus, suggesting the importance of synaptic potentiation in the hippocampus for its therapeutic effects.
Article
Cell Biology
Heizel Rosado-Galindo, Maribella Domenech
Summary: This study demonstrates that surface roughness can influence oncogenic activity in triple-negative breast cancer (TNBC) cells and enrich cancer stem cell (CSC) populations in planar cultures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhijian Jin, Yifan Lu, Xiongyan Wu, Tao Pan, Zhenjia Yu, Junyi Hou, Airong Wu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Chao Yan, Zhenggang Zhu, Bingya Liu, Weihua Qiu, Liping Su
Summary: In this study, anlotinib inhibited gastric cancer (GC) cell growth by inducing apoptosis and G2/M phase arrest in a dose- and time-dependent manner. The interaction between epithelial and stromal cells in the tumor microenvironment affects the response of GC cells to anlotinib. Secreted lactate from GC cells activates cancer-associated fibroblasts (CAFs) to produce BDNF in a NF-kappa B-dependent manner, reducing the sensitivity of GC cells to anlotinib. Targeting the BDNF-TrkB pathway increased the sensitivity of GC cells to anlotinib in a human patient-derived organoid model.
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Rui Han, Zhi-Qing Li, Jun-Ren Yang, Xia Yin, Yu-Qi Gao, Jin-Ming Gao
Summary: This study identified 10 secondary metabolites, including a new lanostane triterpenoid named 2 alpha-hydroxy-inotodiol (2 alpha-HI), from the edible mushroom I. obliquus. The results showed that 2 alpha-HI exhibited remarkable neuroprotective activity against oxidative stress and apoptosis induced by H2O2 in SH-SY5Y cells, mediated by the Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway. Additionally, the neuroprotective effects of 2 alpha-HI were preliminarily verified in zebrafish.
Article
Multidisciplinary Sciences
Anna A. Cook, Sriram Jayabal, Jacky Sheng, Eviatar Fields, Tsz Chui Sophia Leung, Sabrina Quilez, Eileen McNicholas, Lois Lau, Shixia Huang, Alanna J. Watt
Summary: In a mouse model of SCA6, exercise and the TrkB agonist 7,8-DHF were found to increase cerebellar BDNF expression, improve motor coordination and cerebellar cell firing rate deficits, suggesting their potential as therapeutic interventions for SCA6.
Review
Oncology
Mohammad Malekan, Sasan Salehi Nezamabadi, Elham Samami, Mehdi Mohebalizadeh, Amene Saghazadeh, Nima Rezaei
Summary: This article provides an overview of the role of brain-derived neurotrophic factor (BDNF) and its signaling in cancer. Pathological examinations show that BDNF is overexpressed in various cancers and is associated with a poorer prognosis. MicroRNAs have been identified to regulate the BDNF/TrkB pathway, providing a potential mechanism for targeted therapies. Clinical studies investigating agents targeting BDNF receptors and signaling pathways are currently underway. Well-designed clinical trials are needed to further clarify the role of BDNF in cancer progression and its potential as a therapeutic target.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Amanda Almacellas-Barbanoj, Martina Albini, Annyesha Satapathy, Fanny Jaudon, Caterina Michetti, Alicja Krawczun-Rygmaczewska, Huiping Huang, Francesca Manago, Francesco Papaleo, Fabio Benfenati, Fabrizia Cesca
Summary: Kidins220 is a transmembrane scaffold protein involved in fundamental aspects of neuronal physiology. This study demonstrates the importance of Kidins220 splicing and selective knockout in adult brain homeostasis and behavioral phenotypes.
CELL DEATH DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Samar M. Shawki, Mohammed A. Saad, Rania M. Rahmo, Walaa Wadie, Hanan S. El-Abhar
Summary: Liraglutide shows neuroprotective potential in a rat model of Huntington's disease by modulating multiple molecular signaling pathways and reducing apoptosis and oxidative stress, demonstrating a neurotherapeutic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Madhusmita P. Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castren
Summary: Deleting the BDNF receptor TrkB from serotonergic neurons in the adult brain leads to increased levels of 5-HT and Tph2, with abnormal behavioral phenotype in transgenic mice. Despite increased food intake, the transgenic mice are significantly leaner than their wildtype littermates, possibly due to increased metabolic activity. Increased 5-HT levels are associated with significantly increased proliferation of hippocampal progenitors, while long-term survival of newborn cells remains unchanged.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubini
Summary: In Neurodevelopmental Disorders, changes in synaptic plasticity can lead to structural alterations in neuronal circuits involved in cognitive functions. This study tested this hypothesis in mice with the human R451C mutation of the Nlgn3 gene, which is found in some families with autistic children. The results showed that these mice failed to exhibit STD-LTP and this effect persisted into adulthood. Similar results were found in mice lacking the Nlgn3 gene. The loss of STD-LTP was associated with a premature shift of GABA and reduced BDNF availability, suggesting a potential mechanism underlying cognitive deficits in forms of Autism caused by synaptic dysfunctions.
Article
Neurosciences
Dominik Fiedler, Manju Sasi, Robert Blum, Christopher M. Klinke, Marta Andreatta, Hans-Christian Pape, Maren D. Lange
Summary: Researchers have identified that the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) is rich in brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) receptor, which interact to reduce neuronal excitability and mediate long-term depression (LTD) in ovBNST neurons. This suggests that BDNF/TrkB signaling is a critical regulator of synaptic activity in ovBNST, dampening excitability at short and long time scales, and providing a potential entry point for adaptation to stressful environmental encounters, particularly in mediating maladaptive behaviors associated with stress exposure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Pengcheng Chu, Wei Guo, He You, Bai Lu
Summary: Through the study, it was found that Bdnf-e2 transcripts are primarily expressed in the ventromedial hypothalamus (VMH) in mice, and they regulate energy intake and satiety through the TrkB pathway. Re-expressing Bdnf-e2 transcripts in the VMH or activating VMH neurons can alleviate hyperphagia and obesity in Bdnf-e2(-/-) mice.
Article
Nutrition & Dietetics
Fokhrul Hossain, Samarpan Majumder, Justin David, Bruce A. Bunnell, Lucio Miele
Summary: The study investigates how obesity modulates the gut microbiome in a TNBC mouse model, finding that obesity decreases alpha diversity. Obesity was the only significant factor explaining the similarity of bacterial communities. In functional profile analysis, obesity, tumor presence, and obesity-tumor interaction were significant in explaining variation, with obesity having the strongest correlation.
Article
Fisheries
Shupeng Zhang, Yongpei Lu, Yingzi Li, Yanling Liu, Qin Yao, Qin Kang, Shuhuang Chen, Youlian Liu, Yixiao Xiong, Defang Chen, Xin Zhang, Ni Tang, Zhiqiong Li
Summary: This study confirms the anorexigenic effect of brain-derived neurotrophic factor (BDNF) in Siberian sturgeon. Injection of BDNF suppresses feeding and affects the expression of peptide genes.
Article
Biochemistry & Molecular Biology
Yi-Fen Chiang, Ko-Chieh Huang, Hsin-Yuan Chen, Tsui-Chin Huang, Mohamed Ali, Hsin-Yi Chang, Tzong-Ming Shieh, Yin-Hwa Shih, Kai-Lee Wang, Yun-Ju Huang, Cheng-Pei Chung, Shih-Min Hsia
Summary: Obesity is a risk factor for cancer progression as it increases adipokine secretion. Visfatin, a novel adipokine highly expressed in cancer patients, is associated with breast cancer risk. In this study, the effect of visfatin on stemness-related properties in high-malignancy breast cancer cells was investigated. Visfatin treatment significantly increased sphere formation, protein expression of stemness markers, and angiogenesis markers. These effects were reduced by the visfatin inhibitor FK866. The results suggest that visfatin promotes breast cancer stemness and enriches the tumorigenic microenvironment.
Article
Integrative & Complementary Medicine
Jen-Hwey Chiu, Chun-Ju Chang, Jing-Chong Wu, Hui-Ju Liu, Che-Sheng Wen, Chung-Hua Hsu, Jiun-Liang Chen, Ling-Ming Tseng, Wei-Shone Chen, Yi-Ming Shyr
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2014)
Article
Oncology
Yi-Fang Tsai, Chi-Cheng Huang, Yen-Shu Lin, Chih-Yi Hsu, Ching-Po Huang, Chun-Yu Liu, Jen-Hwey Chiu, Ling-Ming Tseng
Summary: The study revealed that IL-17A promotes migratory and angiogenic activity in TNBC tumors, enhances anoikis resistance, and modulates the immune landscape of the tumor microenvironment, favoring cancer metastasis.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Ching-Po Huang, Yi-Fang Tsai, Yen-Shu Lin, Chun-Yu Liu, Tzu-Ting Huang, Chi-Cheng Huang, Jen-Hwey Chiu, Ling-Ming Tseng
Summary: This study aimed to investigate the role of the MEGF11 gene in TNBC cells and its interaction with platelets in promoting tumor cell survival against anoikis. The findings demonstrated that overexpression of MEGF11 rescued TNBC cells from detachment-induced cell death by interacting with platelets. This study provides insights into the biological function of MEGF11 in TNBC cells and its potential as a therapeutic target.
Article
Integrative & Complementary Medicine
Jen-Hwey Chiu, Fang-Pey Chen, Yi-Fang Tsai, Man-Ting Lin, Ling-Ming Tseng, Yi-Ming Shyr
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)