Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin

How to effectively treat acute leukemia patients bearing MLL -rearrangements ?

(2018) Dieter Steinhilber et al.   BIOCHEMICAL PHARMACOLOGY

Pioneering the chromatin landscape

(2018) Kenneth S. Zaret   NATURE GENETICS

Transcription factor retention on mitotic chromosomes: regulatory mechanisms and impact on cell fate decisions

(2017) Mahé Raccaud et al.   FEBS LETTERS

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

(2017) Marc A.J. Morgan et al.   GENES & DEVELOPMENT

H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability

(2017) Younghoon Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA Binding by Histone Methyltransferases Set1 and Set2

(2017) Camille Sayou et al.   MOLECULAR AND CELLULAR BIOLOGY

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification

(2017) Deqing Hu et al.   MOLECULAR CELL

Determinants of Histone H3K4 Methylation Patterns

(2017) Luis M. Soares et al.   MOLECULAR CELL

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

(2017) Kristel M. Dorighi et al.   MOLECULAR CELL

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

(2017) Ryan Rickels et al.   NATURE GENETICS

Mitotic transcription and waves of gene reactivation during mitotic exit

(2017) Katherine C. Palozola et al.   SCIENCE

Smyd3-associated regulatory pathways in cancer

(2017) Antonis Giakountis et al.   SEMINARS IN CANCER BIOLOGY

Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma: a study based on RNA-sequencing and microarray data mining

(2017) Wen-Jie Chen et al.   Oncotarget

Identification of dysregulated long non-coding RNAs/microRNAs/mRNAs in TNM I stage lung adenocarcinoma

(2017) Ziqiang Tian et al.   Oncotarget

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression

(2017) Kelly Chiang et al.   Cell Reports

Mixed-Lineage Leukemia Fusions and Chromatin in Leukemia

(2017) Andrei V. Krivtsov et al.   Cold Spring Harbor Perspectives in Medicine

MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches

(2017) Amanda C. Winters et al.   Frontiers in Pediatrics

How do lncRNAs regulate transcription?

(2017) Yicheng Long et al.   Science Advances

Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage

(2016) Yongcan Chen et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Long Noncoding RNAs in Cancer Pathways

(2016) Adam M. Schmitt et al.   CANCER CELL

SET/MLL family proteins in hematopoiesis and leukemia

(2016) Weiwei Yang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Preferential Phosphorylation on Old Histones during Early Mitosis in Human Cells

(2016) Shu Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

(2016) Nilda L. Alicea-Velázquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells

(2016) Zhenhua Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

(2016) Zizhen Feng et al.   Journal of Hematology & Oncology

Nuclear Reformation at the End of Mitosis

(2016) Anna Katharina Schellhaus et al.   JOURNAL OF MOLECULAR BIOLOGY

Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia

(2016) Jill S. Butler et al.   LEUKEMIA & LYMPHOMA

HOTTIP: a critical oncogenic long non-coding RNA in human cancers

(2016) Yifan Lian et al.   Molecular BioSystems

Structural basis for activity regulation of MLL family methyltransferases

(2016) Yanjing Li et al.   NATURE

Enhancers as non-coding RNA transcription units: recent insights and future perspectives

(2016) Wenbo Li et al.   NATURE REVIEWS GENETICS

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive

(2016) Jovylyn Gatchalian et al.   NUCLEIC ACIDS RESEARCH

Global and cell-type specific properties of lincRNAs with ribosome occupancy

(2016) Hongwei Wang et al.   NUCLEIC ACIDS RESEARCH

The molecular mechanics of mixed lineage leukemia

(2016) R K Slany   ONCOGENE

H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass

(2016) Lan Fang et al.   STEM CELLS

Nascent Connections: R-Loops and Chromatin Patterning

(2016) Frédéric Chédin   TRENDS IN GENETICS

WDR5 high expression and its effect on tumorigenesis in leukemia

(2016) Zheng Ge et al.   Oncotarget

HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development

(2016) Changwang Deng et al.   Cell Reports

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

(2016) Kamila M. Jozwik et al.   Cell Reports

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3

(2016) Ho-Ryun Chung et al.   eLife

Targeting epigenetic regulations in cancer

(2015) Bo Ning et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Epigenetics in autoimmune diseases: Pathogenesis and prospects for therapy

(2015) Zimu Zhang et al.   AUTOIMMUNITY REVIEWS

Designed to Kill: Novel Menin-MLL Inhibitors Target MLL -Rearranged Leukemia

(2015) Michael W.M. Kühn et al.   CANCER CELL

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

(2015) Dmitry Borkin et al.   CANCER CELL

Direct and indirect targeting of MYC to treat acute myeloid leukemia

(2015) Sam Brondfield et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

(2015) David W. Scoville et al.   DIABETES

Histone demethylases in chromatin biology and beyond

(2015) E. Dimitrova et al.   EMBO REPORTS

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

(2015) Pamela Zhang et al.   GENES & DEVELOPMENT

Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark

(2015) Alessandro Bertero et al.   GENES & DEVELOPMENT

Structure and Function of SET and MYND Domain-Containing Proteins

(2015) Nicholas Spellmon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes

(2015) Elizabeth A. Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

(2015) Zhihua Li et al.   Journal of Translational Medicine

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells

(2015) Jin-Man Kim et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Catalog of Currently Documented Histone Modifications

(2015) Yingming Zhao et al.   Cold Spring Harbor Perspectives in Biology

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors

(2015) Zhenhua Yang et al.   PLoS One

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation

(2015) Changcun Guo et al.   Oncotarget

Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deletion inKMT2A(MLL)

(2014) Bryce A. Mendelsohn et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Regulation of Transcription by Long Noncoding RNAs

(2014) Roberto Bonasio et al.   Annual Review of Genetics

Histone lysine methylation and chromatin replication

(2014) Carlos Rivera et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Writing and reading H2B monoubiquitylation

(2014) Gilad Fuchs et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV

(2014) M. J. Murai et al.   BLOOD

De Novo variants in the KMT2A (MLL) gene causing atypical Wiedemann-Steiner syndrome in two unrelated individuals identified by clinical exome sequencing

(2014) Samuel P Strom et al.   BMC Medical Genetics

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

(2014) Chong Chen et al.   CANCER CELL

SnapShot: Histone Modifications

(2014) He Huang et al.   CELL

The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

(2014) A. S. Bledau et al.   DEVELOPMENT

Histone H2B monoubiquitination: roles to play in human malignancy

(2014) Alexander J Cole et al.   ENDOCRINE-RELATED CANCER

Keep-ING balance: Tumor suppression by epigenetic regulation

(2014) Gesche Tallen et al.   FEBS LETTERS

CHARGE and Kabuki syndromes: a phenotypic and molecular link

(2014) Yvonne Schulz et al.   HUMAN MOLECULAR GENETICS

Absent, Small or Homeotic 2-like Protein (ASH2L) Enhances the Transcription of the Estrogen Receptor α Gene through GATA-binding Protein 3 (GATA3)

(2014) Jin Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression

(2014) Tong-peng Xu et al.   Journal of Hematology & Oncology

The PHD finger of p300 Influences Its Ability to Acetylate Histone and Non-Histone Targets

(2014) Johannes G.M. Rack et al.   JOURNAL OF MOLECULAR BIOLOGY

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia

(2014) N Sandhöfer et al.   LEUKEMIA

The emerging roles of DOT1L in leukemia and normal development

(2014) C M McLean et al.   LEUKEMIA

A Role for H3K4 Monomethylation in Gene Repression and Partitioning of Chromatin Readers

(2014) Jemmie Cheng et al.   MOLECULAR CELL

A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer

(2014) Ji-Young Kim et al.   MOLECULAR CELL

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification

(2014) A. Ullius et al.   NUCLEIC ACIDS RESEARCH

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters

(2014) S K Mungamuri et al.   ONCOGENE

DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy

(2014) Wei Liu et al.   PLoS One

A Cascade of Histone Modifications Induces Chromatin Condensation in Mitosis

(2014) Bryan J. Wilkins et al.   SCIENCE

Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

(2014) Yul W Yang et al.   eLife

Readout of Epigenetic Modifications

(2013) Dinshaw J. Patel et al.   Annual Review of Biochemistry

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

(2013) Hannah K. Long et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Malignant genome reprogramming by ATAD2

(2013) Fayçal Boussouar et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

SET1 and p300 Act Synergistically, through Coupled Histone Modifications, in Transcriptional Activation by p53

(2013) Zhanyun Tang et al.   CELL

Long noncoding RNAs in innate and adaptive immunity

(2013) Katherine A. Fitzgerald et al.   CURRENT OPINION IN IMMUNOLOGY

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

Assembling a COMPASS

(2013) Jean-Francois Couture et al.   Epigenetics

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients

(2013) Luca Quagliata et al.   HEPATOLOGY

Ectopic expression of transcription factor AP-2δ in developing retina: effect on PSA-NCAM and axon routing

(2013) Xiaodong Li et al.   JOURNAL OF NEUROCHEMISTRY

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

LSD1 Regulates Pluripotency of Embryonic Stem/Carcinoma Cells through Histone Deacetylase 1-Mediated Deacetylation of Histone H4 at Lysine 16

(2013) F. Yin et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone Methyltransferase KMT2B Is Required for RNA Polymerase II Association and Protection from DNA Methylation at the MagohB CpG Island Promoter

(2013) V. Ladopoulos et al.   MOLECULAR AND CELLULAR BIOLOGY

ASH2L Regulates Ubiquitylation Signaling to MLL: trans-Regulation of H3 K4 Methylation in Higher Eukaryotes

(2013) Lipeng Wu et al.   MOLECULAR CELL

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Molecular basis for chromatin binding and regulation of MLL5

(2013) M. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Menin: a scaffold protein that controls gene expression and cell signaling

(2013) Smita Matkar et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Discovery of Histone Demethylases

(2013) Y. G. Shi et al.   Cold Spring Harbor Perspectives in Biology

USF1 and hSET1A Mediated Epigenetic Modifications Regulate Lineage Differentiation and HoxB4 Transcription

(2013) Changwang Deng et al.   PLoS Genetics

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

De Novo Mutations in MLL Cause Wiedemann-Steiner Syndrome

(2012) Wendy D. Jones et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

(2012) Guillermo Senisterra et al.   BIOCHEMICAL JOURNAL

Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30

(2012) Yong Chen et al.   CELL RESEARCH

Carm1 Regulates Pax7 Transcriptional Activity through MLL1/2 Recruitment during Asymmetric Satellite Stem Cell Divisions

(2012) Yoh-ichi Kawabe et al.   Cell Stem Cell

On WD40 proteins: Propelling our knowledge of transcriptional control?

(2012) Valentina Migliori et al.   Epigenetics

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

(2012) S. S. Dhar et al.   GENES & DEVELOPMENT

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4

(2012) H.-M. Herz et al.   GENES & DEVELOPMENT

A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity

(2012) Jingya Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases

(2012) Venkatasubramanian Dharmarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chromatin Fingerprint of Gene Enhancer Elements

(2012) Gabriel E. Zentner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Trithorax Group Protein Ash2l Is Essential for Pluripotency and Maintaining Open Chromatin in Embryonic Stem Cells

(2012) Ma Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Loss of H2B Ubiquitylation without Corresponding Changes in H3K4 Trimethylation during Myogenic Differentiation

(2012) V. Vethantham et al.   MOLECULAR AND CELLULAR BIOLOGY

A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics

(2012) H. Christian Eberl et al.   MOLECULAR CELL

MLL Histone Methylases Regulate Expression of HDLR-SR-B1 in Presence of Estrogen and Control Plasma Cholesterolin Vivo

(2012) Khairul I. Ansari et al.   MOLECULAR ENDOCRINOLOGY

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

(2012) Pamela Zhang et al.   NUCLEIC ACIDS RESEARCH

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways

(2012) C. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone modifications and mitosis: countermarks, landmarks, and bookmarks

(2012) Fangwei Wang et al.   TRENDS IN CELL BIOLOGY

Histone H3R2 Symmetric Dimethylation and Histone H3K4 Trimethylation Are Tightly Correlated in Eukaryotic Genomes

(2012) Chih-Chi Yuan et al.   Cell Reports

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

(2011) M. Ananthanarayanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Histone Methylases MLL1 and MLL3 Coordinate with Estrogen Receptors in Estrogen-Mediated HOXB9 Expression

(2011) Khairul I. Ansari et al.   BIOCHEMISTRY

Cruciform structures are a common DNA feature important for regulating biological processes

(2011) Václav Brázda et al.   BMC MOLECULAR BIOLOGY

Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network

(2011) Yen-Sin Ang et al.   CELL

Functional and Mechanistic Diversity of Distal Transcription Enhancers

(2011) Michael Bulger et al.   CELL

Readers of histone modifications

(2011) Miyong Yun et al.   CELL RESEARCH

Specificity Analysis-Based Identification of New Methylation Targets of the SET7/9 Protein Lysine Methyltransferase

(2011) Arunkumar Dhayalan et al.   CHEMISTRY & BIOLOGY

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(2011) Shane McManus et al.   EMBO JOURNAL

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

(2011) Yong Chen et al.   EMBO REPORTS

The Nucleosome Remodeling Factor

(2011) Suehyb G. Alkhatib et al.   FEBS LETTERS

Genome-wide function of H2B ubiquitylation in promoter and genic regions

(2011) K. Batta et al.   GENES & DEVELOPMENT

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin

(2011) S. Chantalat et al.   GENOME RESEARCH

H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation

(2011) Wen Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis

(2011) A. Bordlein et al.   JOURNAL OF CELL SCIENCE

HOXC6 Is Transcriptionally Regulated via Coordination of MLL Histone Methylase and Estrogen Receptor in an Estrogen Environment

(2011) Khairul I. Ansari et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of PTIP in Class Switch Recombination and Long-Range Chromatin Interactions at the Immunoglobulin Heavy Chain Locus

(2011) K. R. Schwab et al.   MOLECULAR AND CELLULAR BIOLOGY

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

(2011) Kevin C. Wang et al.   NATURE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain

(2011) Sabina Sarvan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NF-Y Recruits Ash2L to Impart H3K4 Trimethylation on CCAAT Promoters

(2011) Andrea Fossati et al.   PLoS One

Structural and Biochemical Insights into MLL1 Core Complex Assembly

(2011) Vanja Avdic et al.   STRUCTURE

The PHD finger: a versatile epigenome reader

(2011) Roberto Sanchez et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

(2011) Laure Ségurel et al.   PLOS BIOLOGY

Histone Crosstalk Directed by H2B Ubiquitination Is Required for Chromatin Boundary Integrity

(2011) Meiji Kit-Wan Ma et al.   PLoS Genetics

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression,

(2010) Sangho Park et al.   BIOCHEMISTRY

Histone lysine methylation and demethylation pathways in cancer

(2010) Radhika A. Varier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis

(2010) Andrew G. Muntean et al.   CANCER CELL

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes

(2010) Radhika A Varier et al.   EMBO JOURNAL

Ash2l interacts with Tbx1 and is required during early embryogenesis

(2010) Jason Z Stoller et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Epigenetic regulation of cancer growth by histone demethylases

(2010) Soyoung Lim et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1

(2010) Zain Odho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Non-SET Domain Multi-subunit Methyltransferase Required for Sequential Nucleosomal Histone H3 Methylation by the Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

(2010) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

The Dimeric Structure and the Bivalent Recognition of H3K4me3 by the Tumor Suppressor ING4 Suggests a Mechanism for Enhanced Targeting of the HBO1 Complex to Chromatin

(2010) Alicia Palacios et al.   JOURNAL OF MOLECULAR BIOLOGY

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

(2010) T Gan et al.   LEUKEMIA

Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

(2010) A. S. Revenko et al.   MOLECULAR AND CELLULAR BIOLOGY

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Fast signals and slow marks: the dynamics of histone modifications

(2010) Teresa K. Barth et al.   TRENDS IN BIOCHEMICAL SCIENCES

Grasping trimethylation of histone H3 at lysine 4

(2010) Michiel Vermeulen et al.   Epigenomics

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

(2010) Claudia V. Andreu-Vieyra et al.   PLOS BIOLOGY

Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance

(2009) Hitomi Imachi et al.   BREAST CANCER RESEARCH AND TREATMENT

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases

(2009) Shweta Tyagi et al.   EMBO JOURNAL

H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1

(2009) Christian Magerl et al.   HUMAN PATHOLOGY

On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

(2009) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation

(2009) S. Kinkley et al.   JOURNAL OF CELL SCIENCE

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit

(2009) Gerd A. Blobel et al.   MOLECULAR CELL

Structural Basis for the Requirement of Additional Factors for MLL1 SET Domain Activity and Recognition of Epigenetic Marks

(2009) Stacey M. Southall et al.   MOLECULAR CELL

Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

(2009) Tomasz Cierpicki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4

(2009) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

(2009) Stefan Glaser et al.   Epigenetics & Chromatin

The PHD fingers of MLL block MLL fusion protein-mediated transformation

(2008) A. G. Muntean et al.   BLOOD

Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes

(2008) Akihiko Yokoyama et al.   CANCER CELL

Loss of MLL PHD Finger 3 Is Necessary for MLL-ENL-Induced Hematopoietic Stem Cell Immortalization

(2008) J. Chen et al.   CANCER RESEARCH

The Human Trithorax Protein hASH2 Functions as an Oncoprotein

(2008) J. Luscher-Firzlaff et al.   CANCER RESEARCH

Diverse functions of WD40 repeat proteins in histone recognition

(2008) T. Suganuma et al.   GENES & DEVELOPMENT

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

(2008) E. Shema et al.   GENES & DEVELOPMENT

A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex

(2008) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

(2008) M. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

Transcription factor Ap2  associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription

(2008) C. C. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression

(2008) F. E. Erfurth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide

(2008) Karen S. Champagne et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Insight into the Recognition of the H3K4me3 Mark by the TFIID Subunit TAF3

(2008) Hugo van Ingen et al.   STRUCTURE