Keep-ING balance: Tumor suppression by epigenetic regulation

Identifying Candidate Oocyte Reprogramming Factors Using Cross-Species Global Transcriptional Analysis

(2018) Jason P. Awe et al.   Cellular Reprogramming

Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene

(2017) Xiao-Bo Guo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

RegulatING chromatin regulators: post-translational modification of the ING family of epigenetic regulators

(2013) Shankha Satpathy et al.   BIOCHEMICAL JOURNAL

ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients

(2013) J Lu et al.   BRITISH JOURNAL OF CANCER

ING1b-inducible microRNA203 inhibits cell proliferation

(2013) J Chen et al.   BRITISH JOURNAL OF CANCER

ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage

(2013) N. Liu et al.   CANCER RESEARCH

Knockdown of Inhibitor of Growth Protein 2 Inhibits Cell Invasion and Enhances Chemosensitivity to 5-FU in Human Gastric Cancer Cells

(2013) Juan Zhong et al.   DIGESTIVE DISEASES AND SCIENCES

Mammalian DNA demethylation

(2013) Lars Schomacher   Epigenetics

Low ING4 protein expression detected by paraffin-section immunohistochemistry is associated with poor prognosis in untreated patients with gastrointestinal stromal tumors

(2013) Abiyasi Nanding et al.   Gastric Cancer

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3

(2013) A. Schafer et al.   GENES & DEVELOPMENT

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

(2013) M.-E. Lalonde et al.   GENES & DEVELOPMENT

Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways

(2013) Julieta M. Ceruti et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

p90 RSK2 Mediates Antianoikis Signals by both Transcription-Dependent and -Independent Mechanisms

(2013) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumor suppressor ING4 overexpression contributes to proliferation and invasion inhibition in gastric carcinoma by suppressing the NF-κB signaling pathway

(2013) Shijie Li et al.   MOLECULAR BIOLOGY REPORTS

Adenovirus-mediated ING4 expression reduces multidrug resistance of human gastric carcinoma cells in vitro and in vivo

(2013) ZONG-LEI MAO et al.   ONCOLOGY REPORTS

Aberrant Expression miR-196a Is Associated With Abnormal Apoptosis, Invasion, and Proliferation of Pancreatic Cancer Cells

(2013) Minghao Liu et al.   PANCREAS

Src Regulates the Activity of the ING1 Tumor Suppressor

(2013) Lisa Yu et al.   PLoS One

MicroRNA-650 Was a Prognostic Factor in Human Lung Adenocarcinoma and Confers the Docetaxel Chemoresistance of Lung Adenocarcinoma Cells via Regulating Bcl-2/Bax Expression

(2013) Jia-Yuan Huang et al.   PLoS One

ING3 Is Essential for Asymmetric Cell Division during Mouse Oocyte Maturation

(2013) Shinnosuke Suzuki et al.   PLoS One

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

(2013) Anastasia Wyce et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

ING1 induces apoptosis through direct effects at the mitochondria

(2013) P Bose et al.   Cell Death & Disease

Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage

(2013) Dennis J. Bua et al.   Scientific Reports

The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway

(2013) Uma Karthika Rajarajacholan et al.   PLOS BIOLOGY

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

(2012) M. Mraz et al.   BLOOD

Enhanced radiosensitivity of non-small-cell lung cancer (NSCLC) by adenovirus-mediated ING4 gene therapy

(2012) C Ling et al.   CANCER GENE THERAPY

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Expression and prognostic value of ING3 in human primary hepatocellular carcinoma

(2012) Hai-Yan Yang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Correlation between tumor suppressor inhibitor of growth family member 4 expression and microvessel density in breast cancer

(2012) Liangyu Zhang et al.   HUMAN PATHOLOGY

Expression of tumor suppressor gene ING4 in ovarian carcinoma is correlated with microvessel density

(2012) Yinglan Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma

(2012) Zhao-lin Zeng et al.   JOURNAL OF SURGICAL ONCOLOGY

Diverse epigenetic strategies interact to control epidermal differentiation

(2012) Klaas W. Mulder et al.   NATURE CELL BIOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth

(2012) Satbir Thakur et al.   PLoS One

Identification of a Novel Function for the Chromatin Remodeling Protein ING2 in Muscle Differentiation

(2012) Shawn A. Eapen et al.   PLoS One

Negative Regulation of NF-κB by the ING4 Tumor Suppressor in Breast Cancer

(2012) Sara A. Byron et al.   PLoS One

Higher order chromatin organization in cancer

(2012) Karen L. Reddy et al.   SEMINARS IN CANCER BIOLOGY

MicroRNA-193 Pro-Proliferation Effects for Bone Mesenchymal Stem Cells After Low-Level Laser Irradiation Treatment Through Inhibitor of Growth Family, Member 5

(2012) Jue Wang et al.   STEM CELLS AND DEVELOPMENT

ING4 is negatively correlated with microvessel density in colon cancer

(2012) Chun Lou et al.   TUMOR BIOLOGY

Effect of the tumor suppressor gene ING4 on the proliferation of MCF-7 human breast cancer cells

(2012) QINJUN WEI et al.   Oncology Letters

Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma

(2012) MEILING LU et al.   Oncology Letters

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

(2011) Y. Mishima et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence

(2011) E.J.Th. Belt et al.   EUROPEAN JOURNAL OF CANCER

The tumor suppressor p33ING1bupregulates p16INK4aexpression and induces cellular senescence

(2011) Na Li et al.   FEBS LETTERS

The Epigenotype

(2011) C. H. Waddington   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

(2011) Qin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour suppressor ING1b maintains genomic stability upon replication stress

(2011) Ronald P. C. Wong et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma

(2011) Xiao-han Li et al.   ORAL ONCOLOGY

The p53 Tumor Suppressor Is Stabilized by Inhibitor of Growth 1 (ING1) by Blocking Polyubiquitination

(2011) Subhash Thalappilly et al.   PLoS One

The Inhibitor of Growth Protein 5 (ING5) Depends on INCA1 as a Co-Factor for Its Antiproliferative Effects

(2011) Feng Zhang et al.   PLoS One

Modulation of Thyroid Hormone-Dependent Gene Expression in Xenopus laevis by INhibitor of Growth (ING) Proteins

(2011) Caren C. Helbing et al.   PLoS One

Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen

(2011) A. M. Mendes-Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expression of p33ING1, p53, and autophagy-related gene Beclin1 in patients with non-small cell lung cancer

(2011) Jun Liu et al.   TUMOR BIOLOGY

MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity

(2010) XueLi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced antitumor activity by combining an adenovirus harboring ING4 with cisplatin for hepatocarcinoma cells

(2010) Y Xie et al.   CANCER GENE THERAPY

Regulation of the MicroRNA Processor DGCR8 by the Tumor Suppressor ING1

(2010) D. Gomez-Cabello et al.   CANCER RESEARCH

A Dominant Mutant Allele of theING4Tumor Suppressor Found in Human Cancer Cells ExacerbatesMYC-Initiated Mouse Mammary Tumorigenesis

(2010) Suwon Kim et al.   CANCER RESEARCH

Cell Cycle Regulator ING4 Is a Suppressor of Melanoma Angiogenesis That Is Regulated by the Metastasis Suppressor BRMS1

(2010) J. Li et al.   CANCER RESEARCH

ING2 controls the G1to S-phase transition by regulating p21 expression

(2010) Delphine Larrieu et al.   CELL CYCLE

Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

(2010) Karen T. Smith et al.   CHEMISTRY & BIOLOGY

Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry

(2010) María Berdasco et al.   DEVELOPMENTAL CELL

Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact

(2010) Wei-Gang Tong et al.   Epigenetics

HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation

(2010) Jing Nie et al.   FEBS LETTERS

The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas☆

(2010) Hua-chuan Zheng et al.   HUMAN PATHOLOGY

The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression☆

(2010) Ya-nan Xing et al.   HUMAN PATHOLOGY

Dysregulation of miR-15a and miR-214 in human pancreatic cancer

(2010) Xing J Zhang et al.   Journal of Hematology & Oncology

The Dimeric Structure and the Bivalent Recognition of H3K4me3 by the Tumor Suppressor ING4 Suggests a Mechanism for Enhanced Targeting of the HBO1 Complex to Chromatin

(2010) Alicia Palacios et al.   JOURNAL OF MOLECULAR BIOLOGY

Sumoylation of ING2 regulates the transcription mediated by Sin3A

(2010) D Ythier et al.   ONCOGENE

The Inhibitor of Growth 1 (ING1) Is Involved in Trichostatin A-Induced Apoptosis and Caspase 3 Signaling in p53-Deficient Glioblastoma Cells

(2010) Mona Tamannai et al.   ONCOLOGY RESEARCH

Targeted Disruption of Ing2 Results in Defective Spermatogenesis and Development of Soft-Tissue Sarcomas

(2010) Motonobu Saito et al.   PLoS One

Inhibitor of growth-4 promotes I B promoter activation to suppress NF- B signaling and innate immunity

(2010) A. H. Coles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repressive Transcription

(2010) M. G. Guenther et al.   SCIENCE

ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma

(2010) Xiaohan Li et al.   Journal of Oncology

Loss of Inhibitor of Growth (ING-4) is Implicated in the Pathogenesis and Progression of Human Astrocytomas

(2009) George Klironomos et al.   BRAIN PATHOLOGY

Adenovirus-Mediated ING4 Expression Suppresses Pancreatic Carcinoma Cell Growth via Induction of Cell-Cycle Alteration, Apoptosis, and Inhibition of Tumor Angiogenesis

(2009) Yu Feng Xie et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Decreased Expression of Inhibitor of Growth 4 Correlated with Poor Prognosis of Hepatocellular Carcinoma

(2009) F. Fang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

ING Proteins as Potential Anticancer Drug Targets

(2009) M. Unoki et al.   CURRENT DRUG TARGETS

Signaling Pathways of the ING Proteins in Apoptosis

(2009) Sitar Shah et al.   CURRENT DRUG TARGETS

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression

(2009) Kensuke Kumamoto et al.   INTERNATIONAL JOURNAL OF CANCER

Ageing and cancer as diseases of epigenesis

(2009) Scott F. Gilbert   JOURNAL OF BIOSCIENCES

Reduced expression and novel splice variants ofING4in human gastric adenocarcinoma

(2009) Ming Li et al.   JOURNAL OF PATHOLOGY

Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma

(2009) Damien Ythier et al.   LUNG CANCER

Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14

(2009) Limin Cai et al.   MELANOMA RESEARCH

ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation

(2009) Tiffany Hung et al.   MOLECULAR CELL

HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

(2009) Nehmé Saksouk et al.   MOLECULAR CELL

The tumor suppressor ING3 is degraded by SCFSkp2-mediated ubiquitin–proteasome system

(2009) G Chen et al.   ONCOGENE

Inhibitor of Growth 4 Induces Growth Suppression and Apoptosis in Glioma U87MG

(2009) XiaoMei Li et al.   PATHOBIOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

ING1a expression increases during replicative senescence and induces a senescent phenotype

(2008) Mohamed A. Soliman et al.   AGING CELL

ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9

(2008) Frauke Goeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence

(2008) K. Kumamoto et al.   CANCER RESEARCH

p37Ing1bRegulates B-Cell Proliferation and Cooperates with p53 to Suppress Diffuse Large B-Cell Lymphomagenesis

(2008) Andrew H. Coles et al.   CANCER RESEARCH

Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer

(2008) Mehmet Gunduz et al.   CANCER SCIENCE

(de)MYSTification and INGenuity of tumor suppressors

(2008) N. Saksouk et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

p53: A Guide to Apoptosis

(2008) Erik Meulmeester et al.   CURRENT CANCER DRUG TARGETS

NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33ING1b

(2008) Marco Garate et al.   EMBO REPORTS

Two wobble-splicing events affect ING4 protein subnuclear localization and degradation

(2008) K TSAI et al.   EXPERIMENTAL CELL RESEARCH

A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis

(2008) Motoko Unoki et al.   FEBS LETTERS

The Caenorhabditis elegans ing-3 Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway

(2008) J. Luo et al.   GENETICS

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

(2008) Hans T. Bjornsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ING2 as a Novel Mediator of Transforming Growth Factor-β-dependent Responses in Epithelial Cells

(2008) Krishna P. Sarker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Histone H3K4me3 Recognition by ING4

(2008) Alicia Palacios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma

(2008) Silvia S. Borkosky et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

(2008) Xijing Han et al.   NATURE CELL BIOLOGY

DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

(2008) Malcolm V. Brock et al.   NEW ENGLAND JOURNAL OF MEDICINE

SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins

(2008) O Binda et al.   ONCOGENE

The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide

(2008) Karen S. Champagne et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma

(2007) Hua-kun Zhang et al.   CANCER LETTERS

Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues

(2007) Alison A. Walzak et al.   EXPERIMENTAL CELL RESEARCH