The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control

(2015) Ditte Kjærsgaard Klein et al.   Nature Communications

The transcription factor p53: Not a repressor, solely an activator

(2014) Martin Fischer et al.   CELL CYCLE

The CHR site: definition and genome-wide identification of a cell cycle transcriptional element

(2014) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

(2013) Daniel Menendez et al.   NUCLEIC ACIDS RESEARCH

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes

(2013) Martin Fischer et al.   PLoS One

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability

(2012) P. Wolter et al.   JOURNAL OF CELL SCIENCE

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

(2012) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

(2012) Orit Rozenblatt-Rosen et al.   NATURE

p53 Dimers Associate with a Head-to-Tail Response Element to Repress Cyclin B Transcription

(2012) Robert Lipski et al.   PLoS One

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53

(2011) Diego F. Calvisi et al.   HEPATOLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

(2011) Sharon Rashi-Elkeles et al.   Molecular Oncology

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

(2011) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors

(2011) M Dalvai et al.   ONCOGENE

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

(2010) Levin Böhlig et al.   NUCLEIC ACIDS RESEARCH

B-MYB Is Required for Recovery from the DNA Damage-Induced G2 Checkpoint in p53 Mutant Cells

(2009) M. Mannefeld et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription

(2009) Gerd A. Müller et al.   FEBS Journal

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

(2009) Taraswi Banerjee et al.   NUCLEIC ACIDS RESEARCH

Pro-proliferative FoxM1 is a target of p53-mediated repression

(2009) A M Barsotti et al.   ONCOGENE