Stress and DNA repair biology of the Fanconi anemia pathway

Mechanism and regulation of incisions during DNA interstrand cross-link repair

(2014) Jieqiong Zhang et al.   DNA REPAIR

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

(2014) Eeson Rajendra et al.   MOLECULAR CELL

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

(2014) Qin Liang et al.   Nature Chemical Biology

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA

(2014) Simonne Longerich et al.   NUCLEIC ACIDS RESEARCH

Modularized Functions of the Fanconi Anemia Core Complex

(2014) Yaling Huang et al.   Cell Reports

Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

(2013) Massimo Bogliolo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fetal origins of hematopoietic failure in a murine model of Fanconi anemia

(2013) A. N. Kamimae-Lanning et al.   BLOOD

Why does the bone marrow fail in Fanconi anemia?

(2013) J. I. Garaycoechea et al.   BLOOD

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

(2013) A. Hira et al.   BLOOD

The BLM dissolvasome in DNA replication and repair

(2013) Kelly A. Manthei et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fanconi anemia signaling network regulates the spindle assembly checkpoint

(2013) Grzegorz Nalepa et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Fanconi C expression contributes to the emergency granulopoiesis response

(2013) Liping Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivation ofUaf1Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice

(2013) Eunmi Park et al.   MOLECULAR AND CELLULAR BIOLOGY

Linking the Enzymes that Unlink DNA

(2013) Steven J. Brill   MOLECULAR CELL

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks

(2013) Jing Huang et al.   MOLECULAR CELL

FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis

(2013) Eunmi Park et al.   MOLECULAR CELL

Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein

(2013) Anaid Benitez et al.   NUCLEIC ACIDS RESEARCH

Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi Anemia cells

(2013) U Kumari et al.   ONCOGENE

The Inherited Bone Marrow Failure Syndromes

(2013) S. Deborah Chirnomas et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Genomic Characterization of the Inherited Bone Marrow Failure Syndromes

(2013) Payal P. Khincha et al.   SEMINARS IN HEMATOLOGY

Rescuing Stalled or Damaged Replication Forks

(2013) J. T. P. Yeeles et al.   Cold Spring Harbor Perspectives in Biology

Serine Phosphorylation Is Critical for the Activation of Ubiquitin-Specific Protease 1 and Its Interaction with WD40-Repeat Protein UAF1

(2012) Mark A. Villamil et al.   BIOCHEMISTRY

Overcoming reprogramming resistance of Fanconi anemia cells

(2012) L. U. W. Muller et al.   BLOOD

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway

(2012) A. M. Ali et al.   BLOOD

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

The DNA translocase activity of FANCM protects stalled replication forks

(2012) Andrew N. Blackford et al.   HUMAN MOLECULAR GENETICS

Molecular pathogenesis and clinical management of Fanconi anemia

(2012) Younghoon Kee et al.   JOURNAL OF CLINICAL INVESTIGATION

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

(2012) Konstantin I. Piatkov et al.   MOLECULAR CELL

A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

(2012) Zhijiang Yan et al.   MOLECULAR CELL

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

(2012) Weibin Zhou et al.   NATURE GENETICS

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Rev1 by the Fanconi anemia core complex

(2012) Hyungjin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI

(2012) K. Sato et al.   NUCLEIC ACIDS RESEARCH

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

(2012) J. W. C. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome

(2012) K. A. Hoadley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the FANCM–MHF complex reveals physical features for functional assembly

(2012) Yuyong Tao et al.   Nature Communications

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair

(2011) Blanka Sengerová et al.   CELL CYCLE

FANCP/SLX4

(2011) Kelly E. Cybulski et al.   CELL CYCLE

Fanconi anaemia: from a monogenic disease to sporadic cancer

(2011) Antonio Valeri et al.   Clinical & Translational Oncology

Ubiquitylation and the Fanconi anemia pathway

(2011) Elizabeth Garner et al.   FEBS LETTERS

Functional and physical interaction between the mismatch repair and FA-BRCA pathways

(2011) Stacy A. Williams et al.   HUMAN MOLECULAR GENETICS

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway

(2011) Charlotte Hodson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The USP1/UAF1 Complex Promotes Double-Strand Break Repair through Homologous Recombination

(2011) J. Murai et al.   MOLECULAR AND CELLULAR BIOLOGY

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

(2011) Chantal Stoepker et al.   NATURE GENETICS

Mutations of the SLX4 gene in Fanconi anemia

(2011) Yonghwan Kim et al.   NATURE GENETICS

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

(2011) Ivan V Rosado et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

(2011) D. T. Long et al.   SCIENCE

Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

(2011) Woo Joo et al.   SCIENCE

RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis

(2011) Natsuko Suwaki et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

(2010) A. Tulpule et al.   BLOOD

Haematopoeitic cell transplantation for Fanconi anaemia - when and how?

(2010) Margaret L. MacMillan et al.   BRITISH JOURNAL OF HAEMATOLOGY

RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer

(2010) K. Somyajit et al.   CARCINOGENESIS

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

(2010) Raphael Ceccaldi et al.   JOURNAL OF CLINICAL INVESTIGATION

MHF1-MHF2, a Histone-Fold-Containing Protein Complex, Participates in the Fanconi Anemia Pathway via FANCM

(2010) Thiyam Ramsing Singh et al.   MOLECULAR CELL

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

(2010) Zhijiang Yan et al.   MOLECULAR CELL

The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response

(2010) Min Huang et al.   MOLECULAR CELL

Several tetratricopeptide repeat (TPR) motifs of FANCG are required for assembly of the BRCA2/D1-D2-G-X3 complex, FANCD2 monoubiquitylation and phleomycin resistance

(2010) James B. Wilson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Mutation of the RAD51C gene in a Fanconi anemia–like disorder

(2010) Fiona Vaz et al.   NATURE GENETICS

A new nuclease member of the FAN club

(2010) Min Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How the Fanconi Anemia Pathway Guards the Genome

(2009) George-Lucian Moldovan et al.   Annual Review of Genetics

Hematopoietic Stem Cell Transplantation for Bone Marrow Failure Syndromes in Children

(2009) Kasiani C. Myers et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction

(2009) G. Zhi et al.   CANCER RESEARCH

Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype

(2009) Jung Min Kim et al.   DEVELOPMENTAL CELL

Fanconi Anemia

(2009) Allison M. Green et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

(2009) Andrew J. Deans et al.   MOLECULAR CELL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

(2009) Ivan V. Rosado et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24

(2008) J. M. Kim et al.   BLOOD

Fludarabine-based cytoreductive regimen and T-cell-depleted grafts from alternative donors for the treatment of high-risk patients with Fanconi anaemia

(2008) Sonali Chaudhury et al.   BRITISH JOURNAL OF HAEMATOLOGY

Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation

(2008) Caroline Masserot et al.   CANCER

Fanconi anemia proteins stabilize replication forks

(2008) Lily Chien Wang et al.   DNA REPAIR

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

(2008) Masamichi Ishiai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

(2008) J B Wilson et al.   ONCOGENE