Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes

Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor

(2016) V. Darsalia et al.   DIABETES OBESITY & METABOLISM

DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

(2015) MingJie Ma et al.   Cardiovascular Diabetology

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

(2015) V. A. Gault et al.   DIABETES OBESITY & METABOLISM

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

(2014) Nobutaka Koibuchi et al.   Cardiovascular Diabetology

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

(2014) Adviye Ergul et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dual endothelin receptor antagonism with bosentan reverses established vascular remodeling and dysfunctional angiogenesis in diabetic rats: Relevance to glycemic control

(2014) Mohammed Abdelsaid et al.   LIFE SCIENCES

Late dual endothelin receptor blockade with bosentan restores impaired cerebrovascular function in diabetes

(2014) Mohammed Abdelsaid et al.   LIFE SCIENCES

Linagliptin: from bench to bedside

(2014) John Doupis   Drug Design Development and Therapy

Protein nitration impairs the myogenic tone of rat middle cerebral arteries in both ischemic and nonischemic hemispheres after ischemic stroke

(2013) Maha Coucha et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats

(2013) Weiguo Li et al.   BRAIN RESEARCH

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Vascularization Pattern After Ischemic Stroke is Different in Control Versus Diabetic Rats

(2013) Roshini Prakash et al.   STROKE

Glucagon-like peptide-1 preserves coronary microvascular endothelial function after cardiac arrest and resuscitation: potential antioxidant effects

(2012) Betsy B. Dokken et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: Potential implications in cardiovascular disease

(2012) Jixin Zhong et al.   ATHEROSCLEROSIS

Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition

(2012) Swenja Kröller-Schön et al.   CARDIOVASCULAR RESEARCH

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride

(2012) V. Darsalia et al.   DIABETES

Peroxynitrite Decomposition with FeTMPyP Improves Plasma-Induced Vascular Dysfunction and Infarction during Mild but not Severe Hyperglycemic Stroke

(2012) Sara Morales Palomares et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insulin-Induced Generation of Reactive Oxygen Species and Uncoupling of Nitric Oxide Synthase Underlie the Cerebrovascular Insulin Resistance in Obese Rats

(2012) Prasad VG Katakam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Dipeptidyl Peptidase-4 Inhibitor, Des-Fluoro-Sitagliptin, Improves Endothelial Function and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E–Deficient Mice

(2012) Junichi Matsubara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cerebrovascular Complications of Diabetes: Focus on Stroke

(2012) Adviye Ergul et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways

(2011) Zubair Shah et al.   VASCULAR PHARMACOLOGY

Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus

(2011) Chrysi Koliaki et al.   Diabetes Therapy

Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control

(2010) A. Kelly-Cobbs et al.   Acta Physiologica

Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines

(2010) Wataru Takasawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blood Pressure Control in Acute Cerebrovascular Disease

(2010) William B. Owens   Journal of Clinical Hypertension

New behavioral protocols to extend our knowledge of rodent object recognition memory

(2010) M. M. Albasser et al.   LEARNING & MEMORY

Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)

(2010) Liliana Ferreira et al.   MEDIATORS OF INFLAMMATION

Glycemic control prevents microvascular remodeling and increased tone in Type 2 diabetes: link to endothelin-1

(2009) Kamakshi Sachidanandam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cerebrovascular Responses to Insulin in Rats

(2009) Prasad Venkateswera Gurunath Katakam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

(2009) Adviye Ergul et al.   VASCULAR PHARMACOLOGY

Dynamic cerebral autoregulatory capacity is affected early in Type 2 diabetes

(2008) Yu-Sok Kim et al.   CLINICAL SCIENCE

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS