Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

Ring-closing Metathesis in Peptides - the Sting is in the Tail!

(2017) Bianca J. van Lierop et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Stereoselective synthesis and structural elucidation of dicarba peptides

(2016) Ellen C. Gleeson et al.   CHEMICAL COMMUNICATIONS

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

(2016) Tristan I. Croll et al.   STRUCTURE

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

(2015) Mohammed Akhter Hossain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protective hinge in insulin opens to enable its receptor engagement

(2014) J. G. Menting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Design of Non-Standard Insulin Analogs for the Treatment of Diabetes Mellitus

(2012) V. Pandyarajan et al.   Current Diabetes Reports

Modelling dynamics in protein crystal structures by ensemble refinement

(2012) B Tom Burnley et al.   eLife

Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice

(2011) Nicole Wong et al.   ENDOCRINOLOGY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2

(2010) Suode Zhang et al.   PEPTIDES

The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building

(2010) François-Yves Dupradeau et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

(2010) J. Jiracek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Approach to Identify Two Distinct Receptor Binding Surfaces of Insulin-like Growth Factor II

(2009) Clair L. Alvino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

(2009) Mohammed Akhter Hossain et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I

(2008) Lisbeth Gauguin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY