Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

(2016) Yih-Woei C. Fridell et al.   Aging-US

Expression analysis of octopamine and tyramine receptors in Drosophila

(2015) Samar El-Kholy et al.   CELL AND TISSUE RESEARCH

Suppression of Insulin Production and Secretion by a Decretin Hormone

(2015) Ronald W. Alfa et al.   Cell Metabolism

Food odors trigger an endocrine response that affects food ingestion and metabolism

(2015) Oleh V. Lushchak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2

(2015) Young Kwon et al.   DEVELOPMENTAL CELL

IGFBP-3/transferrin/transferrin receptor 1 complexes as principal mediators of IGFBP-3 delivery to colon cells in non-cancer and cancer tissues

(2015) Goran Miljuš et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mio acts in the Drosophila brain to control nutrient storage and feeding

(2015) James E.B. Docherty et al.   GENE

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Two insulin receptors determine alternative wing morphs in planthoppers

(2015) Hai-Jun Xu et al.   NATURE

Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster

(2015) Matthias B. Van Hiel et al.   PEPTIDES

Ovary ecdysteroidogenic hormone requires a receptor tyrosine kinase to activate egg formation in the mosquitoAedes aegypti

(2015) Kevin J. Vogel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide microRNA screening reveals that the evolutionary conserved miR-9a regulates body growth by targeting sNPFR1/NPYR

(2015) Yoon Seok Suh et al.   Nature Communications

Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3

(2015) Jung Kim et al.   Nature Communications

The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila

(2015) Julie L. Hentze et al.   Scientific Reports

The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster

(2015) Hiroko Sano et al.   PLoS Genetics

Nutrition-dependent control of insect development by insulin-like peptides

(2015) Naoki Okamoto et al.   Current Opinion in Insect Science

CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila

(2015) Guilin R. Ren et al.   PLoS One

More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2

(2014) Jan A. Veenstra et al.   CELL AND TISSUE RESEARCH

Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases

(2014) E. Owusu-Ansah et al.   Disease Models & Mechanisms

Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila

(2014) Jian Cao et al.   GENETICS

Insulin receptor-mediated nutritional signalling regulates juvenile hormone biosynthesis and vitellogenin production in the German cockroach

(2014) Marc Abrisqueta et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

MicroRNA miR-8 regulates multiple growth factor hormones produced fromDrosophilafat cells

(2014) G. J. Lee et al.   INSECT MOLECULAR BIOLOGY

Gαq, Gγ1 and Plc21C Control Drosophila Body Fat Storage

(2014) Jens Baumbach et al.   Journal of Genetics and Genomics

Drosophila Insulin-Producing Cells Are Differentially Modulated by Serotonin and Octopamine Receptors and Affect Social Behavior

(2014) Jiangnan Luo et al.   PLoS One

Role of Methoprene-Tolerant (Met) in Adult Morphogenesis and in Adult Ecdysis of Blattella germanica

(2014) Jesus Lozano et al.   PLoS One

The Sleeping Beauty: How Reproductive Diapause Affects Hormone Signaling, Metabolism, Immune Response and Somatic Maintenance in Drosophila melanogaster

(2014) Olga I. Kubrak et al.   PLoS One

Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila

(2014) C. K. Mirth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient control of Drosophila longevity

(2014) Marc Tatar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Genetic Strategy to Measure Circulating Drosophila Insulin Reveals Genes Regulating Insulin Production and Secretion

(2014) Sangbin Park et al.   PLoS Genetics

The contribution of the genomes of a termite and a locust to our understanding of insect neuropeptides and neurohormones

(2014) Jan A. Veenstra   Frontiers in Physiology

Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways

(2014) Immo A. Hansen et al.   Frontiers in Physiology

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions

(2013) Ladan Sarraf-Zadeh et al.   DEVELOPMENTAL BIOLOGY

Structural and Functional Analysis of the Amphioxus IGFBP Gene Uncovers Ancient Origin of IGF-Independent Functions

(2013) Jianfeng Zhou et al.   ENDOCRINOLOGY

A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila

(2013) N. Okamoto et al.   GENES & DEVELOPMENT

Ovary ecdysteroidogenic hormone functions independently of the insulin receptor in the yellow fever mosquito, Aedes aegypti

(2013) Animesh Dhara et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The insulin/TOR signal transduction pathway is involved in the nutritional regulation of juvenile hormone synthesis in Aedes aegypti

(2013) Meritxell Pérez-Hedo et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Crayfish Insulin-like-binding Protein

(2013) Ohad Rosen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IGFBP7 homolog Imp-L2 promotes insulin signaling in distinct neurons of the Drosophila brain

(2013) R. Bader et al.   JOURNAL OF CELL SCIENCE

IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells

(2013) W J Azar et al.   ONCOGENE

Drosophila Adiponectin Receptor in Insulin Producing Cells Regulates Glucose and Lipid Metabolism by Controlling Insulin Secretion

(2013) Su-Jin Kwak et al.   PLoS One

Juvenile Hormone and Insulin Regulate Trehalose Homeostasis in the Red Flour Beetle, Tribolium castaneum

(2013) Jingjing Xu et al.   PLoS Genetics

Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects

(2013) Takashi Koyama et al.   Frontiers in Physiology

Eat to reproduce: a key role for the insulin signaling pathway in adult insects

(2013) Liesbeth Badisco et al.   Frontiers in Physiology

Insulin-like and IGF-like peptides in the silkmoth Bombyx mori: discovery, structure, secretion, and function

(2013) Akira Mizoguchi et al.   Frontiers in Physiology

Factors that regulate insulin producing cells and their output in Drosophila

(2013) Dick R. Nässel et al.   Frontiers in Physiology

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

(2012) Hua Bai et al.   AGING CELL

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Drosophila Cytokine Unpaired 2 Regulates Physiological Homeostasis by Remotely Controlling Insulin Secretion

(2012) Akhila Rajan et al.   CELL

A Fructose Receptor Functions as a Nutrient Sensor in the Drosophila Brain

(2012) Tetsuya Miyamoto et al.   CELL

Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin

(2012) Neval Kapan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects

(2012) Andrea Bednářová et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Insulin-like and testis ecdysiotropin neuropeptides are regulated by the circadian timing system in the brain during larval–adult development in the insect Rhodnius prolixus (Hemiptera)

(2012) Xanthe Vafopoulou et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

How does juvenile hormone control insect metamorphosis and reproduction?

(2012) Lynn M. Riddiford   GENERAL AND COMPARATIVE ENDOCRINOLOGY

FoxO inhibits juvenile hormone biosynthesis and vitellogenin production in the German cockroach

(2012) Songül Süren-Castillo et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation

(2012) A. Garelli et al.   SCIENCE

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

A Mechanism of Extreme Growth and Reliable Signaling in Sexually Selected Ornaments and Weapons

(2012) D. J. Emlen et al.   SCIENCE

IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

(2012) V. Evdokimova et al.   Science Signaling

Insulin-Producing Cells in the Drosophila Brain also Express Satiety-Inducing Cholecystokinin-Like Peptide, Drosulfakinin

(2012) Jeannette A. E. Söderberg et al.   Frontiers in Endocrinology

Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1

(2011) Jae Ryoung Hwang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Presynaptic Facilitation by Neuropeptide Signaling Mediates Odor-Driven Food Search

(2011) Cory M. Root et al.   CELL

Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor

(2011) Jiangnan Luo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

Evolution of the Insulin-Like Growth Factor Binding Protein (IGFBP) Family

(2011) Daniel Ocampo Daza et al.   ENDOCRINOLOGY

Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila

(2011) Joogyung Hyun et al.   FLY

Spatiotemporal patterns of IGF-like peptide expression in the silkmoth Bombyx mori predict its pleiotropic actions

(2011) Naoki Okamoto et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Insulin-like peptides in the mosquito Anopheles stephensi: Identification and expression in response to diet and infection with Plasmodium falciparum

(2011) Alexander G. Marquez et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Molecular analysis of nutritional and hormonal regulation of female reproduction in the red flour beetle, Tribolium castaneum

(2011) R. Parthasarathy et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Juvenile Hormone Regulates Vitellogenin Gene Expression through Insulin-like Peptide Signaling Pathway in the Red Flour Beetle,Tribolium castaneum

(2011) Zhentao Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton

(2011) Masanobu Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos

(2011) Y. Zhong et al.   JOURNAL OF CELL SCIENCE

Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR

(2011) R. T. Birse et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

IRS and TOR nutrient-signaling pathways act via juvenile hormone to influence honey bee caste fate

(2011) N. S. Mutti et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

Insulin Production and Signaling in Renal Tubules of Drosophila Is under Control of Tachykinin-Related Peptide and Regulates Stress Resistance

(2011) Jeannette A. E. Söderberg et al.   PLoS One

SLOB, a SLOWPOKE Channel Binding Protein, Regulates Insulin Pathway Signaling and Metabolism in Drosophila

(2011) Amanda L. Sheldon et al.   PLoS One

DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

(2010) Susan J. Broughton et al.   AGING CELL

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

(2010) Nazif Alic et al.   AGING CELL

Energetics of Insect Diapause

(2010) Daniel A. Hahn et al.   Annual Review of Entomology

Unusual duplication of the insulin-like receptor in the crustacean Daphnia pulex

(2010) Philippe Boucher et al.   BMC EVOLUTIONARY BIOLOGY

Stem Cell Dynamics in Response to Nutrient Availability

(2010) Catherine J. McLeod et al.   CURRENT BIOLOGY

Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity

(2010) Wei Dai et al.   FASEB JOURNAL

Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Aβ-induced neurotoxicity inDrosophila

(2010) Manabu Tsuda et al.   FEBS LETTERS

Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe

(2010) J. Varghese et al.   GENES & DEVELOPMENT

What the loss of the hormone neuroparsin in the melanogaster subgroup of Drosophila can tell us about its function

(2010) Jan A. Veenstra   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

BlockingO-Linked GlcNAc Cycling inDrosophilaInsulin-producing Cells Perturbs Glucose-Insulin Homeostasis

(2010) Osamu Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biological Properties of theDrosophilaInsulin-like Peptide 5 Show Evolutionary Conservation

(2010) Waseem Sajid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relaxin-3/INSL7 Regulates the Stress-response System in the Rat Hypothalamus

(2010) Yoshihisa Watanabe et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities

(2010) Zhimou Wen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior

(2010) Amanda Crocker et al.   NEURON

RNA interference of insulin-related peptide and neuroparsins affects vitellogenesis in the desert locust Schistocerca gregaria

(2010) Liesbeth Badisco et al.   PEPTIDES

Insulin Signaling, Lifespan and Stress Resistance Are Modulated by Metabotropic GABA Receptors on Insulin Producing Cells in the Brain of Drosophila

(2010) Lina E. Enell et al.   PLoS One

Drosophila neuropeptides in regulation of physiology and behavior

(2010) Dick R. Nässel et al.   PROGRESS IN NEUROBIOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila

(2009) Jason Karpac et al.   AGING CELL

IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin

(2009) James Beattie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of metabolic regulation by insulin inDrosophila

(2009) Aurelio A. Teleman   BIOCHEMICAL JOURNAL

Remote Control of Insulin Secretion by Fat Cells in Drosophila

(2009) Charles Géminard et al.   Cell Metabolism

A Drosophila Insulin-like Peptide Promotes Growth during Nonfeeding States

(2009) Maija Slaidina et al.   DEVELOPMENTAL CELL

A Fat Body-Derived IGF-like Peptide Regulates Postfeeding Growth in Drosophila

(2009) Naoki Okamoto et al.   DEVELOPMENTAL CELL

An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori

(2009) Naoki Okamoto et al.   FEBS Journal

Regulatory peptides in fruit fly midgut

(2008) Jan A. Veenstra et al.   CELL AND TISSUE RESEARCH

Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-Like Peptides

(2008) Nathalie Arquier et al.   Cell Metabolism

Opposing Effects of Dietary Protein and Sugar Regulate a Transcriptional Target of Drosophila Insulin-like Peptide Signaling

(2008) Susanne Buch et al.   Cell Metabolism

A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size

(2008) D. D. Kaplan et al.   GENES & DEVELOPMENT

Insulin/TOR signaling in growth and homeostasis: A view from the fly world

(2008) Savraj S. Grewal   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Purification and characterization of an insulin-related peptide in the desert locust, Schistocerca gregaria: immunolocalization, cDNA cloning, transcript profiling and interaction with neuroparsin

(2008) Liesbeth Badisco et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Endocrine regulation of aging and reproduction in Drosophila

(2008) Janne M. Toivonen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs

(2008) Susan Broughton et al.   PLoS One

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons

(2008) J. Clements et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens

(2008) C. Sim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila germ-line modulation of insulin signaling and lifespan

(2008) T. Flatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti

(2008) M. R. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Egg-Laying Site Selection as a System to Study Simple Decision-Making Processes

(2008) C.-h. Yang et al.   SCIENCE

Postmitotic Specification of Drosophila Insulinergic Neurons from Pioneer Neurons

(2008) Irene Miguel-Aliaga et al.   PLOS BIOLOGY