Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

The Metabolic Syndrome and Risk of Prostate Cancer in Italy

(2011) Claudio Pelucchi et al.   ANNALS OF EPIDEMIOLOGY

Targeting the insulin-like growth factor network in cancer therapy

(2011) Isabel Heidegger et al.   CANCER BIOLOGY & THERAPY

Metformin and Incident Breast Cancer among Diabetic Women: A Population-Based Case-Control Study in Denmark

(2011) J. L. F. Bosco et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

(2011) Irina N. Alimova et al.   CELL CYCLE

Long-term effects of insulin glargine on the risk of breast cancer

(2011) S. Suissa et al.   DIABETOLOGIA

Risk of cancer in patients on insulin glargine and other insulin analogues in comparison with those on human insulin: results from a large population-based follow-up study

(2011) R. Ruiter et al.   DIABETOLOGIA

The uncertain relationship between obesity and prostate cancer: An Italian biopsy cohort analysis

(2011) C. De Nunzio et al.   EJSO

Insulin receptor and cancer

(2011) A. Belfiore et al.   ENDOCRINE-RELATED CANCER

Minireview: IGF, Insulin, and Cancer

(2011) Emily J. Gallagher et al.   ENDOCRINOLOGY

Enzymatic features of the glucose metabolism in tumor cells

(2011) Anique Herling et al.   FEBS Journal

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis

(2011) H. Endo et al.   GUT

Diabetes Mellitus, Race and the Odds of High Grade Prostate Cancer in Men Treated With Radiation Therapy

(2011) Timur Mitin et al.   JOURNAL OF UROLOGY

Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer

(2011) Spyros P. Gialamas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Research Resource: New and Diverse Substrates for the Insulin Receptor Isoform A Revealed by Quantitative Proteomics After Stimulation With IGF-II or Insulin

(2011) Alaide Morcavallo et al.   MOLECULAR ENDOCRINOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes and prostate cancer risk in the REDUCE trial

(2011) C Wu et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Medical comorbidities predict mortality in women with a history of early stage breast cancer

(2010) Ruth E. Patterson et al.   BREAST CANCER RESEARCH AND TREATMENT

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

(2010) R. Novosyadlyy et al.   CANCER RESEARCH

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

(2010) M. Bodmer et al.   DIABETES CARE

The Pathway from Diabetes and Obesity to Cancer, on the Route to Targeted Therapy

(2010) Emily Gallagher et al.   Endocrine Practice

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

(2010) Yvonne Fierz et al.   ENDOCRINE-RELATED CANCER

Associations between adipokines and obesity-related cancer

(2010) Gilberto Paz-Filho   Frontiers in Bioscience-Landmark

Diabetes and prognosis in a breast cancer cohort

(2010) Michael G. Schrauder et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Insulin-Like Growth Factor-I and Cancer Mortality in Older Men

(2010) Jacqueline M. Major et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinically Defined Type 2 Diabetes Mellitus and Prognosis in Early-Stage Breast Cancer

(2010) Kirsten Erickson et al.   JOURNAL OF CLINICAL ONCOLOGY

Diabetes Mellitus and Breast Cancer Outcomes: A Systematic Review and Meta-Analysis

(2010) Kimberly S. Peairs et al.   JOURNAL OF CLINICAL ONCOLOGY

A Fully Human Insulin-Like Growth Factor-I Receptor Antibody SCH 717454 (Robatumumab) Has Antitumor Activity as a Single Agent and in Combination with Cytotoxics in Pediatric Tumor Xenografts

(2010) Y. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Ligand-Specific Antibodies to Insulin-Like Growth Factors Suppress Intestinal Polyp Formation in Apc+/- Mice

(2010) T. Matsunaka et al.   MOLECULAR CANCER THERAPEUTICS

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Metastasis suppression by adiponectin

(2010) Neeraj K. Saxena et al.   Cell Adhesion & Migration

Green Tea Catechin Controls Apoptosis in Colon Cancer Cells by Attenuation of H2O2-Stimulated COX-2 Expression via the AMPK Signaling Pathway at Low-Dose H2O2

(2009) In-Ja Park et al.   Annals of the New York Academy of Sciences

Transcriptional and post-translational regulation of adiponectin

(2009) Meilian Liu et al.   BIOCHEMICAL JOURNAL

Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis

(2009) Sarah Khalid et al.   BREAST CANCER RESEARCH AND TREATMENT

Is it Time to Test Metformin in Breast Cancer Clinical Trials?

(2009) M. Cazzaniga et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

(2009) K.-y. Kim et al.   CANCER RESEARCH

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Insulin-Sensitizing Therapy Attenuates Type 2 Diabetes-Mediated Mammary Tumor Progression

(2009) Y. Fierz et al.   DIABETES

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

Insulin glargine use and short-term incidence of malignancies—a population-based follow-up study in Sweden

(2009) J. M. Jonasson et al.   DIABETOLOGIA

Use of insulin glargine and cancer incidence in Scotland: a study from the Scottish Diabetes Research Network Epidemiology Group

(2009) H. M. Colhoun et al.   DIABETOLOGIA

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study

(2009) L. G. Hemkens et al.   DIABETOLOGIA

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Diabetes and cancer

(2009) Paolo Vigneri et al.   ENDOCRINE-RELATED CANCER

Obesity and Breast Cancer: The Estrogen Connection

(2009) Margot P. Cleary et al.   ENDOCRINOLOGY

Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies

(2009) Wensen Chen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy

(2009) Leigh A. Cantrell et al.   GYNECOLOGIC ONCOLOGY

Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner

(2009) R. Rattan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

(2009) J. M. Carboni et al.   MOLECULAR CANCER THERAPEUTICS

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells

(2009) J Zhou et al.   ONCOGENE

The type I insulin-like growth factor receptor regulates cancer metastasis independently of primary tumor growth by promoting invasion and survival

(2009) D Sachdev et al.   ONCOGENE

The protective effect of diabetes mellitus against prostate cancer: Role of sex hormones

(2009) N. Baradaran et al.   PROSTATE

Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database

(2009) S J Freedland et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer

(2008) M. J. Gunter et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women

(2008) M. J. Gunter et al.   CANCER RESEARCH

Effect of Low-Fat Diet on Development of Prostate Cancer and Akt Phosphorylation in the Hi-Myc Transgenic Mouse Model

(2008) N. Kobayashi et al.   CANCER RESEARCH

Serum Prostate-Specific Antigen Levels in Men With Type 2 Diabetes

(2008) M. Fukui et al.   DIABETES CARE

Adipose Tissue: The New Endocrine Organ? A Review Article

(2008) Susan E. Wozniak et al.   DIGESTIVE DISEASES AND SCIENCES

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

(2008) C. Algire et al.   ENDOCRINE-RELATED CANCER

Long-term All-Cause Mortality in Cancer Patients With Preexisting Diabetes Mellitus

(2008) Bethany B. Barone   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

(2008) Mathis Grossmann et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phase I, Pharmacokinetic and Pharmacodynamic Study of the Anti–Insulinlike Growth Factor Type 1 Receptor Monoclonal Antibody CP-751,871 in Patients With Multiple Myeloma

(2008) Martha Q. Lacy et al.   JOURNAL OF CLINICAL ONCOLOGY

Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women

(2008) M. J. Gunter et al.   JNCI-Journal of the National Cancer Institute

Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis

(2008) Jing Ma et al.   LANCET ONCOLOGY

Obesity Accelerates Mouse Mammary Tumor Growth in the Absence of Ovarian Hormones

(2008) Nomelí P. Núñez et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Obesity Is a Significant Risk Factor for Prostate Cancer at the Time of Biopsy

(2008) Stephen J. Freedland et al.   UROLOGY

The role of insulin receptors and IGF-I receptors in cancer and other diseases

(2008) Francesco Frasca et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY