The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

(2018) Nana Kobayashi et al.   Scientific Reports

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

(2017) Elena Puris et al.   JOURNAL OF CONTROLLED RELEASE

Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1)

(2017) Pornparn Kongpracha et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

(2017) Dae Woo Choi et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

(2017) Ryuichi Ohgaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells

(2017) Yu Yamamoto et al.   NUTRITION RESEARCH

DNA methylation of amino acid transporter genes in the human placenta

(2017) C. Simner et al.   PLACENTA

Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment

(2017) Supak Yothaisong et al.   TUMOR BIOLOGY

Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth

(2017) Mariafrancesca Scalise et al.   Frontiers in Oncology

Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment

(2017) Keitaro Hayashi et al.   World Journal of Gastrointestinal Oncology

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(2017) David Dickens et al.   Scientific Reports

Mechanisms involved in the transport of mercuric ions in target tissues

(2016) Christy C. Bridges et al.   ARCHIVES OF TOXICOLOGY

Glutamine transporters in mammalian cells and their functions in physiology and cancer

(2016) Yangzom D. Bhutia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons

(2016) P. Pantham et al.   BIOLOGY OF REPRODUCTION

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

(2016) Arik A. Zur et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LAT-1 activity of meta -substituted phenylalanine and tyrosine analogs

(2016) Evan Augustyn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

(2016) Kristiina M. Huttunen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells

(2016) Keitaro Hayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

(2016) Seiji Ueno et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

(2016) Mikko Gynther et al.   MOLECULAR PHARMACEUTICS

Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC

(2016) Hüseyin Ilgü et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters

(2016) Hideo Otsuki et al.   PROSTATE

Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells

(2016) Marc Le Vee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1

(2015) Manuele Rebsamen et al.   Autophagy

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

(2015) Printip Wongthai et al.   CANCER SCIENCE

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

(2015) Carsten Gram Hansen et al.   CELL RESEARCH

Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2

(2015) S. G. Dann et al.   EMBO JOURNAL

The role of branched chain amino acid and tryptophan metabolism in rat’s behavioral diversity: Intertwined peripheral and brain effects

(2015) Eyal Asor et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter

(2015) Lara Napolitano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Antitumor activity of an anti-CD98 antibody

(2015) Gregory M. Hayes et al.   INTERNATIONAL JOURNAL OF CANCER

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

(2015) Christopher R. Behrens et al.   MOLECULAR PHARMACEUTICS

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth

(2015) Fredrick J. Rosario et al.   Obesity

The effect of histidine on mental fatigue and cognitive performance in subjects with high fatigue and sleep disruption scores

(2015) Ikuko Sasahara et al.   PHYSIOLOGY & BEHAVIOR

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

(2015) Ruth Milkereit et al.   Nature Communications

Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

(2014) Bernadette Carroll et al.   AMINO ACIDS

Quantitative Insight into the Design of Compounds Recognized by theL-Type Amino Acid Transporter 1 (LAT1)

(2014) Henna Ylikangas et al.   ChemMedChem

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

(2014) C Rosilio et al.   LEUKEMIA

Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

(2014) A. Rosell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

(2014) Lorena Pochini et al.   Frontiers in Chemistry

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

(2013) Jordan Gallinetti et al.   BIOCHEMICAL JOURNAL

LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells

(2013) K. Hayashi et al.   JOURNAL OF IMMUNOLOGY

Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203

(2013) Junko Toyoshima et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Amino acid transporters expression in acinar cells is changed during acute pancreatitis

(2013) Ilse Rooman et al.   PANCREATOLOGY

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

(2013) E. G. Geier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cloning, Large Scale Over-Expression in E. coli and Purification of the Components of the Human LAT 1 (SLC7A5) Amino Acid Transporter

(2013) Michele Galluccio et al.   PROTEIN JOURNAL

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

(2013) Mariafrancesca Scalise et al.   Pharmaceutics

CD98 at the crossroads of adaptive immunity and cancer

(2012) J. M. Cantor et al.   JOURNAL OF CELL SCIENCE

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

(2012) KEITARO HAYASHI et al.   ONCOLOGY REPORTS

Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells

(2011) S. Hasegawa et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Up-regulation of l-Type Amino Acid Transporter 1 (LAT1) in Cultured Rat Retinal Capillary Endothelial Cells in Response to Glucose Deprivation

(2011) Ryo Matsuyama et al.   Drug Metabolism and Pharmacokinetics

Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

(2011) Michael F. Wempe et al.   Drug Metabolism and Pharmacokinetics

miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

(2011) Edit Miko et al.   FEBS LETTERS

Solute Carrier Transporters as Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy

(2011) Takeo Nakanishi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

(2011) Lauri Peura et al.   MOLECULAR PHARMACEUTICS

Molecular basis of substrate-induced permeation by an amino acid antiporter

(2011) L. Kowalczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of L-Type Amino Acid Transporter 1 mRNA Expression in Brain Capillaries in a Mouse Model of Parkinson's Disease

(2010) Sumio Ohtsuki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Brain uptake of ketoprofen–lysine prodrug in rats

(2010) Mikko Gynther et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mechanism of substrate recognition and transport by an amino acid antiporter

(2010) Xiang Gao et al.   NATURE

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Structure of a prokaryotic virtual proton pump at 3.2 Å resolution

(2009) Yiling Fang et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity

(2008) Lidia S. Konstantinova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

(2008) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS