Quantitative Insight into the Design of Compounds Recognized by theL-Type Amino Acid Transporter 1 (LAT1)

Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

(2013) Lauri Peura et al.   PHARMACEUTICAL RESEARCH

Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

(2012) Henna Ylikangas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Real External Predictivity of QSAR Models. Part 2. New Intercomparable Thresholds for Different Validation Criteria and the Need for Scatter Plot Inspection

(2012) Nicola Chirico et al.   Journal of Chemical Information and Modeling

R-group template CoMFA combines benefits of “ad hoc” and topomer alignments using 3D-QSAR for lead optimization

(2012) Richard D. Cramer   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Real External Predictivity of QSAR Models: How To Evaluate It? Comparison of Different Validation Criteria and Proposal of Using the Concordance Correlation Coefficient

(2011) Nicola Chirico et al.   Journal of Chemical Information and Modeling

Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

(2011) Lauri Peura et al.   MOLECULAR PHARMACEUTICS

Brain uptake of ketoprofen–lysine prodrug in rats

(2010) Mikko Gynther et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Drug-like Bioactive Structures and Conformational Coverage with the LigPrep/ConfGen Suite: Comparison to Programs MOE and Catalyst

(2010) I-Jen Chen et al.   Journal of Chemical Information and Modeling

Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

(2008) Mikko Gynther et al.   JOURNAL OF MEDICINAL CHEMISTRY