L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells

(2013) Célia Rosilio et al.   CANCER LETTERS

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

(2013) Etienne Boulter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells

(2013) K. Hayashi et al.   JOURNAL OF IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas

(2012) Nobuyuki Yanagisawa et al.   JOURNAL OF CLINICAL PATHOLOGY

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs

(2012) Nada Bulus et al.   PLoS One

Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis

(2011) Mio Furuya et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

(2011) Michael F. Wempe et al.   Drug Metabolism and Pharmacokinetics

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions

(2011) Masaaki Ichinoe et al.   PATHOLOGY INTERNATIONAL

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Targeting autophagy to fight hematopoietic malignancies

(2010) Alexandre Puissant et al.   CELL CYCLE

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Novel therapies for peripheral T-cell non-Hodgkinʼs lymphomas

(2009) Bruce D Cheson   CURRENT OPINION IN HEMATOLOGY

Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways

(2009) W-L Zhao   LEUKEMIA

l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

(2008) Kyoichi Kaira et al.   CANCER SCIENCE

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer

(2008) Takeshi Sakata et al.   PATHOLOGY INTERNATIONAL