A copper(i)-catalyzed asymmetric Mannich reaction of glycine Schiff bases with isatin-derived ketimines: enantioselective synthesis of 3-substituted 3-aminooxindoles

Asymmetric Construction of 3,3-Disubstituted Oxindoles Bearing Vicinal Quaternary–Tertiary Carbon Stereocenters Catalyzed by a Chiral-at-Rhodium Complex

(2017) Huihua Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis

(2017) Xiaohong Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Catalytic 1,2-Hydroperoxidation of Isatin-Derived Ketimine with Hydrogen Peroxide in the Crowding Environment of PEGs

(2017) Wengang Guo et al.   ORGANIC LETTERS

Effective asymmetric vinylogous Mannich reaction of isatin imines with α,α-dicyanoolefins in the presence of a simple chiral amide phosphonium bifunctional phase transfer catalyst

(2017) Cang Cheng et al.   Organic Chemistry Frontiers

Catalytic asymmetric synthesis of hetero-substituted oxindoles

(2017) Renato Dalpozzo   Organic Chemistry Frontiers

Chiral Cu(II)-N4 Complex Catalyzed Asymmetric Aza-Henry Reaction and Its Application in the Synthesis of β -Diamine

(2017) Tusharkumar Menapara et al.   ChemistrySelect

ChiralN,N′-Dioxide-Zinc(II) Complex-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Isatin-Derived Ketimines with Indoles

(2016) Xiying Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

(2016) Fares Ibrahim Amr et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Construction of Cyclic Enaminone-Based 3-Substituted 3-Amino-2-oxindole ScaffoldsviaCatalytic Asymmetric Additions of Isatin-Derived Imines

(2016) Lu-Jia Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Engaging Allene-Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction

(2016) Muthukumar G. Sankar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphine-mediated Highly Enantioselective Spirocyclization with Ketimines as Substrates

(2016) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Imidazolylpyridine-In(OTf)3 catalyzed enantioselective allylation of ketimines derived from isatins

(2016) Tingting Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric Mannich Reaction of Isatin-Based Ketimines with α-Diazomethylphosphonates Catalyzed by Chiral Silver Phosphate

(2016) Jing Chen et al.   ORGANIC LETTERS

Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

(2016) Marc Montesinos-Magraner et al.   ACS Catalysis

Cu(I)-Catalyzed Chemoselective and Stereoselective [3 + 3] Cycloaddition of Azomethine Ylides with 2-Indolylnitroethylenes: Facile Access to Highly Substituted Tetrahydro-γ-Carbolines

(2016) Wu-Lin Yang et al.   ACS Catalysis

Aza-Henry Reaction of Isatin Ketimines with Methyl 4-Nitrobutyrate en Route to Spiro[piperidine-3,3′-oxindoles]

(2015) Melireth Holmquist et al.   ADVANCED SYNTHESIS & CATALYSIS

Brønsted Acid-Catalyzed Enantioselective Synthesis of Isatin- DerivedN,S-Acetals

(2015) Christian Beceño et al.   ADVANCED SYNTHESIS & CATALYSIS

Versatile In Situ GeneratedN-Boc-Imines: Application to Phase-Transfer-Catalyzed Asymmetric Mannich-Type Reactions

(2015) Taichi Kano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters

(2015) Oliver D. Engl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides

(2015) Wu-Lin Yang et al.   CHEMICAL COMMUNICATIONS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Chiral N,O-Ligand/[Cu(OAc)2]-Catalyzed Asymmetric Construction of 4-Aminopyrrolidine Derivatives by 1,3-Dipolar Cycloaddition of Azomethine Ylides with α-Phthalimidoacrylates

(2015) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3-Ethylacetate-Substitued 3-Amino-2-Oxindoles: Formal Synthesis of AG-041R

(2015) Kun Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral Bifunctional Guanidine-Catalyzed Enantioselective Aza-Henry Reaction of Isatin-Derived Ketimines

(2015) Bing Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

Maleimide as an efficient nucleophilic partner in the aza-Morita–Baylis–Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles

(2015) Akshay Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An enantioselective organocatalyzed aza-Morita–Baylis–Hillman reaction of isatin-derived ketimines with acrolein

(2015) Yasushi Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

(2015) Takayoshi Arai et al.   ORGANIC LETTERS

An Organocatalytic Asymmetric Friedel–Crafts Addition/Fluorination Sequence: Construction of Oxindole–Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters

(2015) Xiaoze Bao et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatin-Derived Ketimines

(2015) Qun He et al.   ORGANIC LETTERS

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

(2015) Wu-Lin Yang et al.   ORGANIC LETTERS

Asymmetric synthesis of chiral 3,3-disubstituted oxindoles using isatin as starting material

(2015) Ghodsi Mohammadi Ziarani et al.   TETRAHEDRON-ASYMMETRY

Direct Asymmetric Synthesis of β-Bis-Aryl-α-Amino Acid Esters via Enantioselective Copper-Catalyzed Addition of p-Quinone Methides

(2015) Fu-Sheng He et al.   ACS Catalysis

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines

(2014) Jiannan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly enantioselective aza-Henry reaction with isatin N-Boc ketimines

(2014) Melireth Holmquist et al.   CHEMICAL COMMUNICATIONS

A Highly Enantioselective Mannich-Type Reaction of Glycine Schiff Base Catalyzed by a Cinchoninium Salt

(2014) Zhonglin Tao et al.   CHINESE JOURNAL OF CHEMISTRY

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

(2014) Tian-Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective aza-Morita–Baylis–Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

(2014) Xuan Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

(2014) Takayoshi Arai et al.   ORGANIC LETTERS

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

Synthesis of α,β-diamino acid derivatives via asymmetric Mannich reactions of glycine imino esters catalyzed by a chiral phosphoramidite·silver complex

(2014) Alberto Cayuelas et al.   TETRAHEDRON-ASYMMETRY

Organocatalytic enantioselective aza-Henry reaction of ketimines derived from isatins: access to optically active 3-amino-2-oxindoles

(2014) Akshay Kumar et al.   RSC Advances

An Organocatalytic Addition of Nitromethane to Activated Ketimines

(2014) Yu-Hui Wang et al.   Asian Journal of Organic Chemistry

Recent Developments in Asymmetric Phase-Transfer Reactions

(2013) Seiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclopropenimine-Catalyzed Enantioselective Mannich Reactions of tert-Butyl Glycinates with N-Boc-Imines

(2013) Jeffrey S. Bandar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric catalytic aza-Morita–Baylis–Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral quaternary carbon centers

(2013) Fang-Le Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First example of quinine-squaramide catalyzed enantioselective addition of diphenyl phosphite to ketimines derived from isatins

(2013) Jimil George et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic enantioselective addition of alcohols to isatin-derived N-Boc ketimines

(2013) Tian-Ze Li et al.   TETRAHEDRON

Catalytic asymmetric Mannich reaction of glycine Schiff bases with α-amido sulfones as precursors of aliphatic imines

(2012) Elier Hernando et al.   CHEMICAL COMMUNICATIONS

The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids

(2012) Jingchao Feng et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

syn-Selective Asymmetric Mannich Reaction of Sulfonyl Imines with Iminoesters Catalyzed by the N,N,N-Tridentate Bis(imidazolidine)pyridine (PyBidine)-Cu(OTf)2 Complex

(2012) Takayoshi Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of AG-041R by using N-Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

(2012) Noriyuki Hara et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective and Solvent-Controlled Diastereoselective Mannich Reaction of Isatin Imines with Hydroxyacetone: Synthesis of 3-Substituted 3-Aminooxindoles

(2012) Qi-Xiang Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

(2012) Feng Shi et al.   ORGANIC LETTERS

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

An exo- and Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides with Alkylidene Malonates Catalyzed by a N,O-Ligand/Cu(OAc)2-Derived Chiral Complex

(2011) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ag/ThioClickFerrophos-Catalyzed Enantioselective Mannich Reaction and Amination of Glycine Schiff Base

(2011) Kazumi Imae et al.   JOURNAL OF ORGANIC CHEMISTRY

A Ferrocenyl-DHIPOH/Cu(OAc)2Complex for Diastereo- and Enantioselective Catalysis of the 1,4-Addition of Glycine Derivatives to Alkylidene Malonates

(2011) Yu-Hua Shi et al.   ORGANIC LETTERS

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

(2011) Ke Shen et al.   Chemical Science

Catalytic Asymmetric Mannich Reaction of Glycine Derivatives with N-Tosylimines using Copper(I)/TF-BiphamPhos Complex

(2010) Gang Liang et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

A facile method for the synthesis of oxindole based quaternary α-aminonitriles via the Strecker reaction

(2010) Yun-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantio- and Diastereoselective Mannich Reactions of Glycine Schiff Bases within situGeneratedN-Boc-imines Catalyzed by a Cinchona Alkaloid Thiourea

(2010) Haile Zhang et al.   ORGANIC LETTERS

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Catalytic asymmetric direct Mannich reaction: a powerful tool for the synthesis of α,β-diamino acids

(2009) Ramón Gómez Arrayás et al.   CHEMICAL SOCIETY REVIEWS

AN,N′-Dioxide-Copper(II) Complex as an Efficient Catalyst for the Enantioselective and Diastereoselective Mannich-Type Reaction of Glycine Schiff Bases with Aldimines

(2009) Deju Shang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Substrate-Controlled Diastereoselectivity Switch in Catalytic Asymmetric Direct Mannich Reaction of Glycine Derivatives with Imines: Fromanti- tosyn-α,β-Diamino Acids

(2009) Jorge Hernández-Toribio et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Fluorenone Imines of Glycine Esters and Their Phosphonic Acid Analogues

(2008) Shū Kobayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Mannich Reaction of Glycinate Schiff Bases withN-(8-Quinolyl)sulfonyl Imines: A Catalytic Asymmetric Approach toanti-α,β-Diamino Esters

(2008) Jorge Hernández-Toribio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-peptide arginine-vasopressin antagonists: the vaptans

(2008) Guy Decaux et al.   LANCET