Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

Cycloadditions of Donor-Acceptor Cyclopropanes and Nitriles

(2017) Brian L. Pagenkopf et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

General Approach toward Aspidospermatan-Type Alkaloids Using One-Pot Vilsmeier–Haack Cyclization and Azomethine Ylide Cycloaddition

(2017) Clémence Hauduc et al.   JOURNAL OF ORGANIC CHEMISTRY

Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

(2017) Jeremy Robertson et al.   NATURAL PRODUCT REPORTS

Asymmetric Total Synthesis of Gracilamine and Determination of Its Absolute Configuration

(2017) Xiao-Dong Zuo et al.   ORGANIC LETTERS

Short Approach toward the Nonracemic A,B,E Tricyclic Core of Calyciphylline B-Type Alkaloids

(2017) Patrick Boissarie et al.   ORGANIC LETTERS

Enantioselective Synthesis of (−)-Acetylapoaranotin

(2017) Haoxuan Wang et al.   ORGANIC LETTERS

Current Trends towards the Synthesis of Bioactive Heterocycles and Natural Products Using 1,3-Dipolar Cycloadditions (1,3-DC) with Azomethine Ylides

(2017) H. Döndas et al.   SYNTHESIS-STUTTGART

A sequential cycloaddition strategy for the synthesis of Alsmaphorazine B traces a path through a family of Alstonia alkaloids

(2017) Allen Y. Hong et al.   TETRAHEDRON

Synthesis of biologically active natural products by [3 + 2] cycloaddition of non-stabilized azomethine ylides (AMY): Concepts and realizations

(2017) Ganesh Pandey et al.   TETRAHEDRON LETTERS

Lu's [3 + 2] cycloaddition of allenes with electrophiles: discovery, development and synthetic application

(2017) Yin Wei et al.   Organic Chemistry Frontiers

Tandem Intramolecular Diels–Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications

(2016) Justin E. Sears et al.   ACCOUNTS OF CHEMICAL RESEARCH

Amino Acid-Derived Bifunctional Phosphines for Enantioselective Transformations

(2016) Tianli Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Efficient Formal [2+2+2] Strategy for the Rapid Construction of Polycyclic Spiroindolines: A Concise Synthesis of 11-Demethoxy-16-epi -myrtoidine

(2016) Jun Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyrone Diels-Alder Routes to Indolines and Hydroindolines: Syntheses of Gracilamine, Mesembrine, and Δ7 -Mesembrenone

(2016) Pei Gan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Eight-Step Enantioselective Total Synthesis of (−)-Cycloclavine

(2016) Stephanie R. McCabe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expeditious and Divergent Total Syntheses of Aspidosperma Alkaloids Exploiting Iridium(I)-Catalyzed Generation of Reactive Enamine Intermediates

(2016) Peng Wen Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Daphenylline

(2016) Ryosuke Yamada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cutting-Edge and Time-Honored Strategies for Stereoselective Construction of C–N Bonds in Total Synthesis

(2016) Artur K. Mailyan et al.   CHEMICAL REVIEWS

Studies toward Total Synthesis of (±)-Caldaphnidine C via One-Pot Sequential Intramolecular Vilsmeier–Haack and Azomethine Ylide 1,3-Dipolar Cycloaddition

(2016) Jonathan Boudreault et al.   JOURNAL OF ORGANIC CHEMISTRY

Studies on the Synthesis of the Alkaloid (−)-Gilbertine via Indolidene Chemistry

(2016) Ken S. Feldman et al.   JOURNAL OF ORGANIC CHEMISTRY

Formal Synthesis of Gracilamine Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1-Yne–Vinylcyclopropanes and CO

(2016) Sritama Bose et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Total Synthesis of (−)-Actinophyllic Acid

(2016) Lingchao Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis, biosynthesis and biological profiles of clavine alkaloids

(2016) Stephanie R. McCabe et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Route to the C,D,E Ring System of the Aspidosperma Alkaloids

(2016) Geoffrey M. Giampa et al.   ORGANIC LETTERS

Annulation Reactions of Donor–Acceptor Cyclopropanes with (1-Azidovinyl)benzene and 3-Phenyl-2H-azirine

(2016) Joanne E. Curiel Tejeda et al.   ORGANIC LETTERS

Access to the Pyrroloindoline Core via [3 + 2] Annulation as well as the Application in the Synthetic Approach to (±)-Minfiensine

(2016) Wenzhi Ji et al.   ORGANIC LETTERS

Efficient Strategy for the Construction of Both Enantiomers of the Octahydropyrroloquinolinone Ring System: Total Synthesis of (+)-Aspidospermidine

(2016) Ganesh Pandey et al.   ORGANIC LETTERS

Biomimetic Total Synthesis of the Pentacyclic Amaryllidaceae Alkaloid Derivative Gracilamine

(2016) Nadia (Yuqian) Gao et al.   ORGANIC LETTERS

Synthetic studies on the application of the intramolecular azide-alkene 1,3-dipolar cycloaddition reaction in the construction of the core structure of complex alkaloids

(2016) Irene de Miguel et al.   TETRAHEDRON

Progress in 1,3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis

(2016) Maya Shankar Singh et al.   TETRAHEDRON

Synthesis of β -prolinols via [3+2] cycloaddition and one-pot programmed reduction: Valuable building blocks for polyheterocycles

(2016) Jundong Li et al.   TETRAHEDRON LETTERS

Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and Development of Inspired Methodology Suitable for the Systematic Study of Their Structure–Function Properties

(2015) Justin E. Sears et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol

(2015) Jundong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric [3+2] Annulation Approach to 3-Pyrrolines: Concise Total Syntheses of (−)-Supinidine, (−)-Isoretronecanol, and (+)-Elacomine

(2015) Isaac Chogii et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors

(2015) Steven W. M. Crossley et al.   CHEMICAL REVIEWS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Highly Selective Copper-Catalyzed Asymmetric [3+2] Cycloaddition of Azomethine Ylides with Acyclic 1,3-Dienes

(2015) María González-Esguevillas et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Total Synthesis of Galanthamine Involving De Novo Construction of the Aromatic C-Ring

(2015) Jeremy Nugent et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Indolidenes and Indolidenium Intermediates in the Synthesis of Cyclopent[b]indoles: Mechanistic Studies on Intramolecular Cyclizations

(2015) Ken S. Feldman et al.   JOURNAL OF ORGANIC CHEMISTRY

Dearomative Indole Cycloaddition Reactions of Aza-Oxyallyl Cationic Intermediates: Modular Access to Pyrroloindolines

(2015) Arjun Acharya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dearomative Indole (3 + 2) Reactions with Azaoxyallyl Cations – New Method for the Synthesis of Pyrroloindolines

(2015) Maria C. DiPoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the azatricyclic ACD ring system of calyciphylline A-type Daphniphyllum alkaloids via a nonstabilized azomethine ylide generated by desilylation

(2015) Ding Ma et al.   TETRAHEDRON LETTERS

A Zincke aldehyde approach to gelsemine

(2015) Jonathan K. Lam et al.   TETRAHEDRON LETTERS

Synthesis of Allokainic Acid: A Review

(2015) Chinmay Bhat et al.   Asian Journal of Organic Chemistry

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Total Synthesis of (−)-Lansai B and (+)-Nocardioazines A and B

(2014) Haoxuan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Gracilamine

(2014) Yingbo Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A concise [C+NC+CC] coupling-enabled synthesis of kaitocephalin

(2014) Philip Garner et al.   CHEMICAL COMMUNICATIONS

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Iridium-Catalyzed Reductive Nitro-Mannich Cyclization

(2014) Alex W. Gregory et al.   CHEMISTRY-A EUROPEAN JOURNAL

Intramolecular [3 + 2] Cyclocondensations of Alkenes with Indolidenes and Indolidenium Cations

(2014) Ken S. Feldman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Syntheses of (−)-Kopsifoline D and (−)-Deoxoapodine: Divergent Total Synthesis via Late-Stage Key Strategic Bond Formation

(2014) Kiyoun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (−)-Pyrrolines

(2014) Christopher E. Henry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies towards the synthesis of calyciphylline A-type Daphniphyllum alkaloids

(2014) Baldip Kang et al.   NATURAL PRODUCT REPORTS

Synthetic strategies toward hetidine and hetisine-type diterpenoid alkaloids

(2014) Amy M. Hamlin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Synthesis of α-Heteroarylpyrrolidines by Copper-Catalyzed 1,3-Dipolar Cycloaddition of α-Silylimines

(2014) Ana Pascual-Escudero et al.   ORGANIC LETTERS

Catalytic Asymmetric Exo-Selective [C+NC+CC] Reaction

(2014) Ryan Joseph et al.   ORGANIC LETTERS

Short Total Synthesis of (−)-Kainic Acid

(2014) Kentaro Oe et al.   ORGANIC LETTERS

Trapping the elusive aza-oxyallylic cation: new opportunities in heterocycloaddition chemistry

(2014) Korry L. Barnes et al.   TETRAHEDRON LETTERS

1,3-Carbon D–A strategy for [3 + 2] cycloadditions/annulations with imines: synthesis of functionalized pyrrolidines and related alkaloids

(2014) Indresh Kumar   RSC Advances

Synthesis of Functionalized Bicyclic IminesviaIntramolecular Azide-Alkene 1,3-Dipolar Cycloaddition/Intramolecular Stork Alkylation Cascade Reaction

(2013) Irene de Miguel et al.   ADVANCED SYNTHESIS & CATALYSIS

A Catalytic Asymmetric Synthesis of Polysubstituted Piperidines Using a Rhodium(I)-Catalyzed [2+2+2] Cycloaddition Employing a Cleavable Tether

(2013) Timothy J. Martin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic Studies Concerning the Crinine Alkaloid Haemultine

(2013) Nadia (Yuqian) Gao et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Catalytic C–C Bond-Forming Multi-Component Cascade or Domino Reactions: Pushing the Boundaries of Complexity in Asymmetric Organocatalysis

(2013) Chandra M. R. Volla et al.   CHEMICAL REVIEWS

Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters

(2013) Lindsay M. Repka et al.   JOURNAL OF ORGANIC CHEMISTRY

Total synthesis of the Daphniphyllum alkaloid daphenylline

(2013) Zhaoyong Lu et al.   Nature Chemistry

Catalytic, Asymmetric Indolizidinone Aza-Quaternary Stereocenter Synthesis: Expedient Synthesis of the Cylindricine Alkaloid Core

(2013) Derek M. Dalton et al.   ORGANIC LETTERS

Total Synthesis of Kopsinine

(2013) Jian Xie et al.   ORGANIC LETTERS

Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening–Formal [3 + 2] Cycloaddition

(2013) Giada Arena et al.   ORGANIC LETTERS

Synthesis of Demissidine by a Ring Fragmentation 1,3-Dipolar Cycloaddition Approach

(2013) Zhe Zhang et al.   ORGANIC LETTERS

Direct, enantioselective synthesis of pyrroloindolines and indolines from simple indole derivatives

(2013) Jane Ni et al.   TETRAHEDRON

Asymmetric formal total synthesis of the stemofoline alkaloids: the evolution, development, and application of a catalytic dipolar cycloaddition cascade

(2013) Charles S. Shanahan et al.   TETRAHEDRON

Formal and total synthesis of (±)-cycloclavine

(2013) Nitinkumar D. Jabre et al.   TETRAHEDRON LETTERS

Perfluorinated Taddol phosphoramidite as an L,Z-ligand on Rh(i) and Co(−i): evidence for bidentate coordination via metal–C6F5 interaction

(2013) Derek M. Dalton et al.   Chemical Science

Intramolecular C(sp3)–H amination

(2013) Jenna L. Jeffrey et al.   Chemical Science

Synthesis of the Tetracyclic Core Structure of (±)-Nakadomarin A through Azomethine Ylide-Alkene [3+2] Cycloaddtion

(2013) Fufang Wu et al.   Asian Journal of Organic Chemistry

Intramolecular Azide-Alkene 1,3-Dipolar Cycloaddition/Enamine Addition(s) Cascade Reaction: Synthesis of Nitrogen-Containing Heterocycles

(2012) Irene de Miguel et al.   ADVANCED SYNTHESIS & CATALYSIS

Potentially Biomimetic Total Synthesis and Relative Stereochemical Assignment of (±)-Gracilamine

(2012) Songchuan Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Formal Total Syntheses of Didehydrostemofoline and Isodidehydrostemofoline through a Catalytic Dipolar Cycloaddition Cascade

(2012) Chao Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis

(2012) Jeffrey S. Cannon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Synthesis of α-Quaternary Proline Derivatives by 1,3-Dipolar Cycloaddition of α-Silylimines

(2012) Jorge Hernández-Toribio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (−)-Lycoposerramine-S

(2012) Naoaki Shimada et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of fused tricyclic amines unsubstituted at the ring-junction positions by a cascade condensation, cyclization, cycloaddition then decarbonylation strategy

(2012) Iain Coldham et al.   Beilstein Journal of Organic Chemistry

Cu-catalyzed asymmetric [3+2] cycloaddition of α-iminoamides with activated olefins

(2012) María González-Esguevillas et al.   CHEMICAL COMMUNICATIONS

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

First Total Synthesis of the Pyrrolizidine Alkaloid Amphorogynine C through Intramolecular Azide-Olefin Cycloaddition

(2012) Irene de Miguel et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Syntheses of (-)-α-Kainic Acid

(2012) Christos I. Stathakis et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereoelectronic Effects in the Fragmentation of γ-Silyloxy-β-hydroxy-α-diazocarbonyl Compounds

(2012) Nitinkumar D. Jabre et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of the Tetracyclic Core (ABCE Rings) of Daphenylline

(2012) Bowen Fang et al.   JOURNAL OF ORGANIC CHEMISTRY

[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675

(2012) Philip Garner et al.   ORGANIC LETTERS

Allenyl Azide Cycloaddition Chemistry: Application to the Total Synthesis of (±)-Meloscine

(2012) Ken S. Feldman et al.   ORGANIC LETTERS

Total Synthesis of (−)-(α)-Kainic Acid via a Diastereoselective Intramolecular [3 + 2] Cycloaddition Reaction of an Aryl Cyclopropyl Ketone with an Alkyne

(2012) Zhi Luo et al.   ORGANIC LETTERS

Synthesis studies on the Melodinus alkaloid meloscine

(2012) Ken S. Feldman et al.   TETRAHEDRON

Efficient total synthesis of manzacidin B

(2012) Tetsuro Shinada et al.   TETRAHEDRON LETTERS

The intramolecular Diels–Alder reaction of tryptamine-derived Zincke aldehydes is a stepwise process

(2012) Hung V. Pham et al.   Chemical Science

Enantioselective total synthesis of (+)-ibophyllidine via an asymmetric phosphine-catalyzed [3 + 2] annulation

(2012) Ian P. Andrews et al.   Chemical Science

Bicyclic Cyclopentenones via the Combination of an Iridium- Catalyzed Allylic Substitution with a Diastereoselective Intramolecular Pauson-Khand Reaction

(2011) Andreas Farwick et al.   ADVANCED SYNTHESIS & CATALYSIS

Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines

(2011) Xiaoyu Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)-α-Kainic Acid

(2011) Martin A. Lowe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

One-Step Stereospecific Strategy for the Construction of the Core Structure of the 5,11-Methanomorphanthridine Alkaloids in Racemic as well as in Optically Pure Form: Synthesis of (±)-Pancracine and (±)-Brunsvigine

(2011) Ganesh Pandey et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Reactivity and Synthesis Inspired by the Zincke Ring-Opening of Pyridines

(2011) Christopher D. Vanderwal   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric [C + NC + CC] Coupling Entry to the Naphthyridinomycin Natural Product Family: Formal Total Synthesis of Cyanocycline A and Bioxalomycin β2

(2011) Philip Garner et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of the Core Ring System of the Yuzurimine-TypeDaphniphyllumAlkaloids by Cascade Condensation, Cyclization, Cycloaddition Chemistry

(2011) Iain Coldham et al.   JOURNAL OF ORGANIC CHEMISTRY

Syntheses of Strychnine, Norfluorocurarine, Dehydrodesacetylretuline, and Valparicine Enabled by Intramolecular Cycloadditions of Zincke Aldehydes

(2011) David B. C. Martin et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Total Synthesis of (−)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine

(2011) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of (±)-Cycloclavine and (±)-5-epi-Cycloclavine

(2011) Filip R. Petronijevic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Total Synthesis of (±)-Minfiensine

(2011) Peijun Liu et al.   ORGANIC LETTERS

Cascade Cyclization, Dipolar Cycloaddition to Bridged Tricyclic Amines Related to theDaphniphyllumAlkaloids

(2011) Iain Coldham et al.   ORGANIC LETTERS

The Total Synthesis of the Crinine Alkaloid Hamayne via a Pd[0]-Catalyzed Intramolecular Alder-Ene Reaction

(2011) Laurent Petit et al.   ORGANIC LETTERS

Intramolecular Diels–Alder Cycloaddition/Rearrangement Cascade of an Amidofuran Derivative for the Synthesis of (±)-Minfiensine

(2011) Gang Li et al.   ORGANIC LETTERS

Synthesis of the Tetracyclic Core of Daphnilactone B-Type and Yuzurimine-Type Alkaloids

(2011) Guillaume Bélanger et al.   ORGANIC LETTERS

Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

(2011) Mou-Nuo Cheng et al.   ORGANIC LETTERS

Toward a total synthesis of the stemofoline alkaloids: advancement of a 1,3-dipolar cycloaddition strategy

(2011) Charles S. Shanahan et al.   TETRAHEDRON LETTERS

A synthesis of strychnine by a longest linear sequence of six steps

(2011) David B. C. Martin et al.   Chemical Science

Phosphine-catalyzed one-pot isomerization of 3-alkynoates and [2 + 3]-cycloaddition with imines: formal synthesis of Securinega alkaloid (±)-allosecurinine

(2011) Magesh Sampath et al.   Chemical Science

The Pd-Catalyzed Alder–Ene Reactions ofN-Protected and Propargylated 1-Amino-2-aryl-2-cyclohexenes as a New Route to C3a-Arylhexahydroindoles: Towards the Total Synthesis of Tazettine

(2010) Anna L. Lehmann et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α-Iminonitriles

(2010) Rocío Robles-Machín et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cyclization Cascade of Allenyl Azides: Synergy Between Theory and Experiment

(2010) Olalla Nieto Faza et al.   CURRENT ORGANIC CHEMISTRY

Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions

(2010) Adam J.M. Burrell et al.   CURRENT ORGANIC SYNTHESIS

The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis

(2010) P. Garner et al.   CURRENT ORGANIC SYNTHESIS

Construction of the 5,10b-Phenanthridine Skeleton Using [3+2]-Cycloaddition of a Non-Stabilized Azomethine Ylide: Total Synthesis of (±)-Maritidine and (±)-Crinine Alkaloids

(2010) Ganesh Pandey et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (+)-Fendleridine (Aspidoalbidine) and (+)-1-Acetylaspidoalbidine

(2010) Erica L. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Pyrroloindolines by a Formal [3 + 2] Cycloaddition Reaction

(2010) Lindsay M. Repka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and Highly Selective Sulfur Ylide Mediated Asymmetric Epoxidations and Aziridinations Using an Inexpensive, Readily Available Chiral Sulfide. Applications to the Synthesis of Quinine and Quinidine

(2010) Ona Illa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition

(2010) Adam. J. M. Burrell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective Total Synthesis of (−)-α-Kainic Acid

(2010) Andreas Farwick et al.   ORGANIC LETTERS

Highly Diastereoselective Synthesis of Substituted Pyrrolidines Using a Sequence of Azomethine Ylide Cycloaddition and Nucleophilic Cyclization

(2010) Guillaume Bélanger et al.   ORGANIC LETTERS

Intramolecular annulations of donor–acceptor cyclopropanes

(2010) Terry P. Lebold et al.   PURE AND APPLIED CHEMISTRY

Novel entry to the tricyclic core of stemofoline and didehydrostemofoline

(2010) Jochen Dietz et al.   TETRAHEDRON LETTERS

Highly enantio-, regio- and diastereo-selective one-pot [2 + 3]-cycloaddition reaction via isomerization of 3-butynoates to allenoates,

(2010) Magesh Sampath et al.   Chemical Science

Total Synthesis of Indolizidine Alkaloid (−)-209D: Overriding Substrate Bias in the Asymmetric Rhodium-Catalyzed [2+2+2] Cycloaddition

(2009) Robert T. Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions

(2009) Yukihiro Motoyama et al.   CHEMICAL COMMUNICATIONS

Multi-component cycloaddition approaches in the catalytic asymmetric synthesis of alkaloid targets

(2009) Stéphane Perreault et al.   CHEMICAL SOCIETY REVIEWS

Organocatalysis—after the gold rush

(2009) Søren Bertelsen et al.   CHEMICAL SOCIETY REVIEWS

Heterocycles from cyclopropanes: applications in natural product synthesis

(2009) Cheryl A. Carson et al.   CHEMICAL SOCIETY REVIEWS

The Daphniphyllum Alkaloids

(2009) Mei Dong et al.   CURRENT ORGANIC CHEMISTRY

Allenyl Azide Cycloaddition Chemistry. 2,3-Cyclopentennelated Indole Synthesis through Indolidene Intermediates

(2009) Ken S. Feldman et al.   JOURNAL OF ORGANIC CHEMISTRY

An Efficient Synthetic Approach to Polycyclic 2,5-Dihydropyrroles from α-Silyloxy Ketones

(2009) Cristian Draghici et al.   JOURNAL OF ORGANIC CHEMISTRY

Predictable and Regioselective Insertion of Internal Unsymmetrical Alkynes in Rhodium-Catalyzed Cycloadditions with Alkenyl Isocyanates

(2009) Rebecca Keller Friedman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Rhodium-Catalyzed [2 + 2 + 2] Cycloadditions of Terminal Alkynes and Alkenyl Isocyanates: Mechanistic Insights Lead to a Unified Model that Rationalizes Product Selectivity

(2009) Derek M. Dalton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Access to the Core of theStrychnos,AspidospermaandIbogaAlkaloids. A Short Synthesis of Norfluorocurarine

(2009) David B. C. Martin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Daphniphyllum alkaloids

(2009) Jun'ichi Kobayashi et al.   NATURAL PRODUCT REPORTS

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

(2009) Carmen Nájera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A

(2009) Iain Coldham et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Excess Substrate is a Spectator Ligand in a Rhodium-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Alkenyl Isocyanates with Tolanes

(2009) Mark Emil Oinen et al.   ORGANIC LETTERS

Synthesis of Fused Tricyclic Amines from Enolizable Acyclic Aldehydes by Cyclization then Dipolar Cycloaddition Cascade: Synthesis of Myrioxazine A

(2009) Adam J. M. Burrell et al.   ORGANIC LETTERS

Total Synthesis of FR901483

(2009) Cheryl A. Carson et al.   ORGANIC LETTERS

Stereodivergent Synthesis of Fused Bicyclopyrazolidines: Access to Pyrazolines and Pyrrolidines

(2009) Terry P. Lebold et al.   ORGANIC LETTERS

Stereoselective One-Step Construction of Vicinal Quaternary and Tertiary Stereocenters of the 5,10b-Ethanophenanthridine Skeleton: Total Synthesis of (±)-Maritidine

(2009) Ganesh Pandey et al.   ORGANIC LETTERS

Regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of alkynes and isocyanates to form pyridones

(2009) Kevin M. Oberg et al.   TETRAHEDRON

Tandem double intramolecular [4+2]/[3+2] cycloadditions of nitroalkenes: construction of the pentacyclic core structure of daphnilactone B

(2009) Scott E. Denmark et al.   TETRAHEDRON

Total Synthesis of (−)-Allosecurinine

(2008) Andrew B. Leduc et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (+)-Alexine by Utilizing a Highly Stereoselective [3+2] Annulation Reaction of anN-Tosyl-α-Amino Aldehyde and a 1,3-Bis(silyl)propene

(2008) Martina Dressel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of AntiproliferativeCephalotaxus Esters and Their Evaluation against Several Human Hematopoietic and Solid Tumor Cell Lines: Uncovering Differential Susceptibilities to Multidrug Resistance

(2008) Joseph D. Eckelbarger et al.   CHEMISTRY-A EUROPEAN JOURNAL

Allenyl Azide Cycloaddition Chemistry: Exploration of the Scope and Mechanism of Cyclopentennelated Dihydropyrrole Synthesis through Azatrimethylenemethane Intermediates

(2008) Ken S. Feldman et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Formation of Fused Tricyclic Amines from Acyclic Aldehydes by a Cascade Process Involving Condensation, Cyclization, and Dipolar Cycloaddition

(2008) Adam J. M. Burrell et al.   JOURNAL OF ORGANIC CHEMISTRY

A Concise Total Synthesis of (−)-Quinocarcin via Aryne Annulation

(2008) Kevin M. Allan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lewis Acid Promoted Carbon−Carbon Bond Cleavage of γ-Silyloxy-β-hydroxy-α-diazoesters

(2008) Cristian Draghici et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation

(2008) Christopher D. Gilmore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of the Strychnos Alkaloid (+)-Minfiensine: Tandem Enantioselective Intramolecular Heck−Iminium Ion Cyclization

(2008) Amy B. Dounay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bis-Sulfonyl Ethylene as Masked Acetylene Equivalent in Catalytic Asymmetric [3 + 2] Cycloaddition of Azomethine Ylides

(2008) Ana López-Pérez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergent Methodology for the Synthesis of Complex Pyrrolidines

(2008) Stephen K. Jackson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allenyl Azide Cycloaddition Chemistry. Photochemical Initiation and CuI Mediation Leads to Improved Regioselectivity

(2008) Ken S. Feldman et al.   ORGANIC LETTERS

New Access to 1-Deoxynojirimycin Derivatives via Azide−Alkene Cycloaddition

(2008) Ying Zhou et al.   ORGANIC LETTERS

Enantioselective Synthesis of Indolizidines Bearing Quaternary Substituted Stereocenters via Rhodium-Catalyzed [2 + 2 + 2] Cycloaddition of Alkenyl Isocyanates and Terminal Alkynes

(2008) Ernest E. Lee et al.   ORGANIC LETTERS

A Versatile Cascade of Intramolecular Vilsmeier−Haack and Azomethine Ylide 1,3-Dipolar Cycloaddition toward Tricyclic Cores of Alkaloids†

(2008) François Lévesque et al.   ORGANIC LETTERS

Application of an intramolecular dipolar cycloaddition to an asymmetric synthesis of the fully oxygenated tricyclic core of the stemofoline alkaloids

(2008) Ryan J. Carra et al.   TETRAHEDRON

Cascade cyclization intermolecular dipolar cycloaddition by multi-component couplings—synthesis of indolizidines and pyrrolizidines

(2008) Iain Coldham et al.   TETRAHEDRON LETTERS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Asymmetric Synthetic Access to the Hetisine Alkaloids: Total Synthesis of (+)-Nominine

(2007) Kevin M. Peese et al.   CHEMISTRY-A EUROPEAN JOURNAL